NFATC3

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (mRNA)

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RefSeq (protein)

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Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.[1][2]

Function

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.[2]

See also

References

  1. Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
  2. 2.0 2.1 "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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