MLL (gene)

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Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
PBB Protein MLL image.jpg
PDB rendering based on 2j2s.
Identifiers
Symbols MLL ; ALL-1; CXXC7; HRX; HTRX1; MLL/GAS7; MLL1A; TRX1
External IDs OMIM: 159555 MGI96995 HomoloGene4338
RNA expression pattern
PBB GE MLL 212080 at tn.png
PBB GE MLL 212076 at tn.png
PBB GE MLL 212078 s at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 4297
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 214162

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000118058
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000002028

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q03164
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q5DTR3

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_005933 (mRNA)
NP_005924 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |XM_110671 (mRNA)
XP_110671 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 11: 117.81 - 117.9 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 9: 44.55 -  44.63 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

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Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), also known as MLL, is a human gene.

MLL is a histone methyltransferase deemed a positive global regulator of gene transcription. This protein belongs to the group of histone-modifying enzymes and is involved in the epigenetic maintenance of transcriptional memory and the pathogenesis of human leukemias.[1] It also may participate in the process of GAD67 downregulation in schizophrenia.[2]

References

  1. Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, Young RA (2005). "Global and Hox-specific roles for the MLL1 methyltransferase". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8603–8. doi:10.1073/pnas.0503072102. PMID 15941828. free fulltext
  2. Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S (2007). "Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters". J. Neurosci. 27 (42): 11254–62. doi:10.1523/JNEUROSCI.3272-07.2007. PMID 17942719. commented at schizophreniaforum.org

Further reading

  • Marschalek R, Nilson I, Löchner K; et al. (1998). "The structure of the human ALL-1/MLL/HRX gene". Leuk. Lymphoma. 27 (5–6): 417–28. PMID 9477123.
  • Eguchi M, Eguchi-Ishimae M, Greaves M (2004). "The role of the MLL gene in infant leukemia". Int. J. Hematol. 78 (5): 390–401. PMID 14704031.
  • Daser A, Rabbitts TH (2004). "Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis". Genes Dev. 18 (9): 965–74. doi:10.1101/gad.1195504. PMID 15132992.
  • Li ZY, Liu DP, Liang CC (2005). "New insight into the molecular mechanisms of MLL-associated leukemia". Leukemia. 19 (2): 183–90. doi:10.1038/sj.leu.2403602. PMID 15618964.
  • Douet-Guilbert N, Morel F, Le Bris MJ; et al. (2005). "Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation". Leuk. Lymphoma. 46 (1): 143–6. doi:10.1080/104281904000010783. PMID 15621793.

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