Germ cell nuclear factor

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Template:Infobox gene The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene.[1][2] GCNF is a member of the nuclear receptor family of intracellular transcription factors .

In adults, GCNH is expressed mainly in the germ cells of gonads and is involved in the regulation of embryogenesis and germ cell differentiation.[3]

Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants.[4]


  1. Lei W, Hirose T, Zhang LX, Adachi H, Spinella MJ, Dmitrovsky E, Jetten AM (Apr 1997). "Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation". Journal of Molecular Endocrinology. 18 (2): 167–76. PMID 9134503. doi:10.1677/jme.0.0180167. 
  2. Süsens U, Borgmeyer U (Dec 1996). "Characterization of the human germ cell nuclear factor gene". Biochimica et Biophysica Acta. 1309 (3): 179–82. PMID 8982251. doi:10.1016/s0167-4781(96)00157-1. 
  3. Zechel C (Dec 2005). "The germ cell nuclear factor (GCNF)". Molecular Reproduction and Development. 72 (4): 550–6. PMID 16155958. doi:10.1002/mrd.20377. 
  4. "Entrez Gene: NR6A1 nuclear receptor subfamily 6, group A, member 1". 

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