HOXD11

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SpeciesHumanMouse
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Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.[3] [4][5][6]

See also

References

  1. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. 3.0 3.1 "Entrez Gene: HOXD11 homeobox D11".
  4. Davis AP, Capecchi MR (1 August 1994). "Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11". Development. 120 (8): 2187–98. PMID 7925020.
  5. Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR (June 1995). "Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11". Nature. 375 (6534): 791–5. doi:10.1038/375791a0. PMID 7596412.
  6. Davis AP, Capecchi MR (1 April 1996). "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse". Development. 122 (4): 1175–85. PMID 8620844.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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