Aryl hydrocarbon receptor repressor

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aryl-hydrocarbon receptor repressor
Identifiers
Symbol AHRR
Alt. Symbols AHH, AHHR
Entrez 57491
HUGO 346
OMIM 606517
RefSeq NM_020731
UniProt Q9ULI6
Other data
Locus Chr. 5 p15.33
Dioxin is a teratogen that exerts its effects through the aryl hydrocarbon receptor in conjunction with the receptor's binding partner, aryl hydrocarbon receptor nuclear translocator. The protein encoded by this gene represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor-kappa B.

External links

  • Kanno Y, Takane Y, Izawa T, Nakahama T, Inouye Y (2006). "The Inhibitory Effect of Aryl Hydrocarbon Receptor Repressor (AhRR) on the Growth of Human Breast Cancer MCF-7 Cells.". Biol Pharm Bull 29 (6): 1254-7. PMID 16755028.
  • Roy N, Courtenay S, Chambers R, Wirgin I (2006). "Characterization of the aryl hydrocarbon receptor repressor and a comparison of its expression in Atlantic tomcod from resistant and sensitive populations.". Environ Toxicol Chem 25 (2): 560-71. PMID 16519320.
  • Yamamoto J, Ihara K, Nakayama H, Hikino S, Satoh K, Kubo N, Iida T, Fujii Y, Hara T (2004). "Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells.". Life Sci 74 (8): 1039-49. PMID 14672759.
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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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