STAT1
| Signal transducer and activator of transcription 1, 91kDa | |||||||||||||
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File:Stat1 stucture.png STAT1 bound to DNA | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | STAT1 ; DKFZp686B04100; ISGF-3; STAT91 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 21428 | ||||||||||||
| RNA expression pattern | |||||||||||||
| File:PBB GE STAT1 200887 s at tn.png | |||||||||||||
| More reference expression data | |||||||||||||
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| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
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STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I or type II interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon Stimulated Response Element) promoter element.[1] In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).
Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.[2]
References
- ↑ Michael G. Katze, Yupeng He & Michael Gale; et al. (2002). "Viruses and interferon: a fight for supremacy". Nature Reviews Immunology. 2 (9): 675–87. doi:10.1038/nri888. PMID 12209136.
- ↑ Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG. (2007). "Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR". Cancer Genomics Proteomics. 4 (2): 93–97. PMID 17804871.
Further reading
- Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction". Intervirology. 42 (5–6): 325–30. PMID 10702714.
- Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene. 285 (1–2): 1–24. PMID 12039028.
- Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1): 87–94. PMID 15638726.