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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Interferon regulatory factor 2''' is a [[protein]] that in humans is encoded by the ''IRF2'' [[gene]].<ref name="pmid2475256">{{cite journal | vauthors = Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T | title = Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes | journal = Cell | volume = 58 | issue = 4 | pages = 729–39 | date = September 1989 | pmid = 2475256 | pmc = | doi = 10.1016/0092-8674(89)90107-4 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_IRF2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1irf.
| PDB = {{PDB2|1irf}}, {{PDB2|1irg}}, {{PDB2|2irf}}
| Name = Interferon regulatory factor 2
| HGNCid = 6117
| Symbol = IRF2
| AltSymbols =; DKFZp686F0244; IRF-2
| OMIM = 147576
| ECnumber = 
| Homologene = 1659
| MGIid = 96591
| GeneAtlas_image1 = PBB_GE_IRF2_203275_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3660
    | Hs_Ensembl = ENSG00000168310
    | Hs_RefseqProtein = NP_002190
    | Hs_RefseqmRNA = NM_002199
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 185545909
    | Hs_GenLoc_end = 185632697
    | Hs_Uniprot = P14316
    | Mm_EntrezGene = 16363
    | Mm_Ensembl = ENSMUSG00000031627
    | Mm_RefseqmRNA = NM_008391
    | Mm_RefseqProtein = NP_032417
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 48238594
    | Mm_GenLoc_end = 48346283
    | Mm_Uniprot = Q2TAX8
  }}
}}
'''Interferon regulatory factor 2''', also known as '''IRF2''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the [[IRF1]]-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of [[histone H4]].<ref>{{cite web | title = Entrez Gene: IRF2 interferon regulatory factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3660| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the [[IRF1]]-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.<ref>{{cite web | title = Entrez Gene: IRF2 interferon regulatory factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3660| accessdate = }}</ref>
}}


==See also==
== See also ==
*[[IRF1]]
*[[IRF1]]
*[[Interferon regulatory factors]]
*[[Interferon regulatory factors]]


==References==
== Interactions ==
{{reflist|2}}


==Further reading==
IRF2 has been shown to [[Protein-protein interaction|interact]] with [[BRD7]],<ref name=pmid11025449>{{cite journal | vauthors = Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ | title = Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2 | journal = J. Cell. Physiol. | volume = 185 | issue = 2 | pages = 269–79 | date = November 2000 | pmid = 11025449 | doi = 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L }}</ref> [[EP300]]<ref name=pmid11304541>{{cite journal | vauthors = Masumi A, Ozato K | title = Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 20973–80 | date = June 2001 | pmid = 11304541 | doi = 10.1074/jbc.M101707200 }}</ref> and [[PCAF]].<ref name=pmid11304541/><ref name=pmid10022868>{{cite journal | vauthors = Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K | title = The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 1810–20 | date = March 1999 | pmid = 10022868 | pmc = 83974 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Harada H, Taniguchi T, Tanaka N | title = The role of interferon regulatory factors in the interferon system and cell growth control | journal = Biochimie | volume = 80 | issue = 8–9 | pages = 641–50 | year = 1999 | pmid = 9865486 | doi = 10.1016/S0300-9084(99)80017-0 }}
| citations =
* {{cite journal | vauthors = Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA | title = Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth | journal = Biochimie | volume = 80 | issue = 8–9 | pages = 651–8 | year = 1999 | pmid = 9865487 | doi = 10.1016/S0300-9084(99)80018-2 }}
*{{cite journal | author=Harada H, Taniguchi T, Tanaka N |title=The role of interferon regulatory factors in the interferon system and cell growth control. |journal=Biochimie |volume=80 |issue= 8-9 |pages= 641-50 |year= 1999 |pmid= 9865486 |doi= }}
* {{cite journal | vauthors = Itoh S, Harada H, Fujita T, Mimura T, Taniguchi T | title = Sequence of a cDNA coding for human IRF-2 | journal = Nucleic Acids Res. | volume = 17 | issue = 20 | pages = 8372 | year = 1989 | pmid = 2813069 | pmc = 334978 | doi = 10.1093/nar/17.20.8372 }}
*{{cite journal | author=Pitha PM, Au WC, Lowther W, ''et al.'' |title=Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth. |journal=Biochimie |volume=80 |issue= 8-9 |pages= 651-8 |year= 1999 |pmid= 9865487 |doi= }}
* {{cite journal | vauthors = Harada H, Takahashi E, Itoh S, Harada K, Hori TA, Taniguchi T | title = Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system | journal = Mol. Cell. Biol. | volume = 14 | issue = 2 | pages = 1500–9 | year = 1994 | pmid = 7507207 | pmc = 358505 | doi =  }}
*{{cite journal | author=Harada H, Fujita T, Miyamoto M, ''et al.'' |title=Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. |journal=Cell |volume=58 |issue= 4 |pages= 729-39 |year= 1989 |pmid= 2475256 |doi= }}
* {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | year = 1995 | pmid = 7566098 | doi = <!-- none available --> | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format = PDF }}
*{{cite journal | author=Itoh S, Harada H, Fujita T, ''et al.'' |title=Sequence of a cDNA coding for human IRF-2. |journal=Nucleic Acids Res. |volume=17 |issue= 20 |pages= 8372 |year= 1989 |pmid= 2813069 |doi=  }}
* {{cite journal | vauthors = Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ | title = Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors | journal = J. Biol. Chem. | volume = 270 | issue = 22 | pages = 13063–9 | year = 1995 | pmid = 7768900 | doi = 10.1074/jbc.270.22.13063 }}
*{{cite journal | author=Harada H, Takahashi E, Itoh S, ''et al.'' |title=Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1500-9 |year= 1994 |pmid= 7507207 |doi= }}
* {{cite journal | vauthors = Cha Y, Deisseroth AB | title = Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region | journal = J. Biol. Chem. | volume = 269 | issue = 7 | pages = 5279–87 | year = 1994 | pmid = 8106512 | doi =  }}
*{{cite journal  | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi= }}
* {{cite journal | vauthors = Harada H, Kitagawa M, Tanaka N, Yamamoto H, Harada K, Ishihara M, Taniguchi T | title = Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2 | journal = Science | volume = 259 | issue = 5097 | pages = 971–4 | year = 1993 | pmid = 8438157 | doi = 10.1126/science.8438157 }}
*{{cite journal | author=Sharf R, Azriel A, Lejbkowicz F, ''et al.'' |title=Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13063-9 |year= 1995 |pmid= 7768900 |doi=  }}
* {{cite journal | vauthors = Drew PD, Franzoso G, Carlson LM, Biddison WE, Siebenlist U, Ozato K | title = Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells | journal = J. Neuroimmunol. | volume = 63 | issue = 2 | pages = 157–62 | year = 1996 | pmid = 8550813 | doi = 10.1016/0165-5728(95)00140-9 }}
*{{cite journal | author=Cha Y, Deisseroth AB |title=Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region. |journal=J. Biol. Chem. |volume=269 |issue= 7 |pages= 5279-87 |year= 1994 |pmid= 8106512 |doi= }}
* {{cite journal | vauthors = Birnbaum MJ, van Zundert B, Vaughan PS, Whitmarsh AJ, van Wijnen AJ, Davis RJ, Stein GS, Stein JL | title = Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo | journal = J. Cell. Biochem. | volume = 66 | issue = 2 | pages = 175–83 | year = 1997 | pmid = 9213219 | doi = 10.1002/(SICI)1097-4644(19970801)66:2<175::AID-JCB5>3.0.CO;2-N }}
*{{cite journal | author=Harada H, Kitagawa M, Tanaka N, ''et al.'' |title=Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. |journal=Science |volume=259 |issue= 5097 |pages= 971-4 |year= 1993 |pmid= 8438157 |doi= }}
* {{cite journal | vauthors = Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K | title = The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 1810–20 | year = 1999 | pmid = 10022868 | pmc = 83974 | doi =  }}
*{{cite journal  | author=Drew PD, Franzoso G, Carlson LM, ''et al.'' |title=Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells. |journal=J. Neuroimmunol. |volume=63 |issue= 2 |pages= 157-62 |year= 1996 |pmid= 8550813 |doi= }}
* {{cite journal | vauthors = Li W, Nagineni CN, Hooks JJ, Chepelinsky AB, Egwuagu CE | title = Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors | journal = Invest. Ophthalmol. Vis. Sci. | volume = 40 | issue = 5 | pages = 976–82 | year = 1999 | pmid = 10102295 | doi =  }}
*{{cite journal  | author=Birnbaum MJ, van Zundert B, Vaughan PS, ''et al.'' |title=Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo. |journal=J. Cell. Biochem. |volume=66 |issue= 2 |pages= 175-83 |year= 1997 |pmid= 9213219 |doi=  }}
* {{cite journal | vauthors = Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV, Trent JM, McFarland HF, Biddison WE | title = Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays | journal = Ann. Neurol. | volume = 46 | issue = 3 | pages = 425–8 | year = 1999 | pmid = 10482277 | doi = 10.1002/1531-8249(199909)46:3<425::AID-ANA22>3.0.CO;2-O }}
*{{cite journal | author=Masumi A, Wang IM, Lefebvre B, ''et al.'' |title=The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1810-20 |year= 1999 |pmid= 10022868 |doi=  }}
* {{cite journal | vauthors = Mild GC, Schmahl GE, Shayan P, Niemeyer CM | title = Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia | journal = Leuk. Lymphoma | volume = 35 | issue = 5–6 | pages = 507–11 | year = 2000 | pmid = 10609788 | doi = 10.1080/10428199909169615 }}
*{{cite journal | author=Li W, Nagineni CN, Hooks JJ, ''et al.'' |title=Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors. |journal=Invest. Ophthalmol. Vis. Sci. |volume=40 |issue= 5 |pages= 976-82 |year= 1999 |pmid= 10102295 |doi= }}
* {{cite journal | vauthors = Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ | title = Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2 | journal = J. Cell. Physiol. | volume = 185 | issue = 2 | pages = 269–79 | year = 2000 | pmid = 11025449 | doi = 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L }}
*{{cite journal | author=Whitney LW, Becker KG, Tresser NJ, ''et al.'' |title=Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. |journal=Ann. Neurol. |volume=46 |issue= 3 |pages= 425-8 |year= 1999 |pmid= 10482277 |doi= }}
* {{cite journal | vauthors = Larrea E, Alberdi A, Castelruiz Y, Boya P, Civeira MP, Prieto J | title = Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5 | journal = J. Viral Hepat. | volume = 8 | issue = 2 | pages = 103–10 | year = 2001 | pmid = 11264730 | doi = 10.1046/j.1365-2893.2001.00273.x }}
*{{cite journal | author=Mild GC, Schmahl GE, Shayan P, Niemeyer CM |title=Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia. |journal=Leuk. Lymphoma |volume=35 |issue= 5-6 |pages= 507-11 |year= 2000 |pmid= 10609788 |doi= }}
* {{cite journal | vauthors = Masumi A, Ozato K | title = Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 20973–80 | year = 2001 | pmid = 11304541 | doi = 10.1074/jbc.M101707200 }}
*{{cite journal  | author=Staal A, Enserink JM, Stein JL, ''et al.'' |title=Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. |journal=J. Cell. Physiol. |volume=185 |issue= 2 |pages= 269-79 |year= 2000 |pmid= 11025449 |doi= 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L }}
*{{cite journal  | author=Larrea E, Alberdi A, Castelruiz Y, ''et al.'' |title=Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5. |journal=J. Viral Hepat. |volume=8 |issue= 2 |pages= 103-10 |year= 2001 |pmid= 11264730 |doi=  }}
*{{cite journal | author=Masumi A, Ozato K |title=Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 20973-80 |year= 2001 |pmid= 11304541 |doi= 10.1074/jbc.M101707200 }}
}}
{{refend}}
{{refend}}


== External links ==
==External links==
* {{MeshName|IRF2+protein,+human}}
*{{Commonscatinline|Interferon regulatory factor-2, IRF-2}}
*{{MeshName|IRF2+protein,+human}}


{{gene-4-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{PDB Gallery|geneid=3660}}
{{Transcription factors|g3}}
{{JAK-STAT signaling pathway}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-4-stub}}

Latest revision as of 11:59, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.[1]

Function

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.[2]

See also

Interactions

IRF2 has been shown to interact with BRD7,[3] EP300[4] and PCAF.[4][5]

References

  1. ↑ Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A, Miyata T, Taniguchi T (September 1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell. 58 (4): 729–39. doi:10.1016/0092-8674(89)90107-4. PMID 2475256.
  2. ↑ "Entrez Gene: IRF2 interferon regulatory factor 2".
  3. ↑ Staal A, Enserink JM, Stein JL, Stein GS, van Wijnen AJ (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–79. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449.
  4. ↑ 4.0 4.1 Masumi A, Ozato K (June 2001). "Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment". J. Biol. Chem. 276 (24): 20973–80. doi:10.1074/jbc.M101707200. PMID 11304541.
  5. ↑ Masumi A, Wang IM, Lefebvre B, Yang XJ, Nakatani Y, Ozato K (March 1999). "The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. PMC 83974. PMID 10022868.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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