Type I cytokine receptor

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Type I cytokine receptors are proteins expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.


The signal transducing chains are often shared between different receptors within this receptor family.[1]


Type I cytokine receptors include:


  1. Abbas AK, and Lichtman, Cellular and Molecular Immunology (5th Ed.) Editor: Saunders, Philadelphia, 2003.
  2. He et al., Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. J Immunol. 1995 Feb 15;154(4):1596-605
  3. Woodcock et al., Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 1994 November 1; 13(21): 5176–5185.

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