PHF21A: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''PHD finger protein 21A''' is a [[protein]] that in humans is encoded by the ''PHF21A'' [[gene]].<ref name="pmid11214970">{{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 6 | pages = 347–55 | year = 2000 | date = Feb 2001 | pmid = 11214970 | pmc =  | doi = 10.1093/dnares/7.6.347 }}</ref><ref name="pmid12032298">{{cite journal | vauthors = Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R | title = A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 11 | pages = 7420–5  | date = May 2002 | pmid = 12032298 | pmc = 124246 | doi = 10.1073/pnas.112008599 }}</ref><ref name="entrez"/>
'''PHD finger protein 21A''' is a [[protein]] that in humans is encoded by the ''PHF21A'' [[gene]].<ref name="pmid11214970">{{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 6 | pages = 347–55 | year = 2000 | pmid = 11214970 | doi = 10.1093/dnares/7.6.347 }}</ref><ref name="pmid12032298">{{cite journal | vauthors = Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R | title = A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 11 | pages = 7420–5  | date = May 2002 | pmid = 12032298 | pmc = 124246 | doi = 10.1073/pnas.112008599 }}</ref><ref name="entrez"/>


== Function ==
== Function ==
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== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 7234–9 | year = 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 }}
* {{cite journal | vauthors = Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T | title = Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression | journal = Biochem. Biophys. Res. Commun. | volume = 322 | issue = 2 | pages = 601–8 | year = 2004 | pmid = 15325272 | doi = 10.1016/j.bbrc.2004.07.163 }}
* {{cite journal | vauthors = Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y | title = Regulation of LSD1 histone demethylase activity by its associated factors | journal = Mol. Cell | volume = 19 | issue = 6 | pages = 857–64 | year = 2005 | pmid = 16140033 | doi = 10.1016/j.molcel.2005.08.027 }}
* {{cite journal | vauthors = Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y | title = Regulation of LSD1 histone demethylase activity by its associated factors | journal = Mol. Cell | volume = 19 | issue = 6 | pages = 857–64 | year = 2005 | pmid = 16140033 | doi = 10.1016/j.molcel.2005.08.027 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

Latest revision as of 10:44, 15 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.[1][2][3]

Function

BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM][3]

Interactions

PHF21A has been shown to interact with:

References

  1. ↑ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
  3. ↑ 3.0 3.1 "Entrez Gene: PHF21A PHD finger protein 21A".
  4. ↑ 4.0 4.1 4.2 4.3 Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (Sep 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
  5. ↑ Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.

Further reading

  • Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors". Mol. Cell. 19 (6): 857–64. doi:10.1016/j.molcel.2005.08.027. PMID 16140033.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Hailesellasse Sene K, Porter CJ, Palidwor G, Perez-Iratxeta C, Muro EM, Campbell PA, Rudnicki MA, Andrade-Navarro MA (2007). "Gene function in early mouse embryonic stem cell differentiation". BMC Genomics. 8: 85. doi:10.1186/1471-2164-8-85. PMC 1851713. PMID 17394647.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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