RCOR1

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REST corepressor 1
Image:PBB Protein RCOR1 image.jpg
PDB rendering based on 2iw5.
Available structures: 2iw5, 2uxn, 2v1d
Identifiers
Symbol(s) RCOR1; COREST; KIAA0071; RCOR
External IDs OMIM: 607675 MGI: 106340 Homologene: 32246
Orthologs
Human Mouse
Entrez 23186 217864
Ensembl ENSG00000089902 ENSMUSG00000037896
Uniprot Q9UKL0 Q8CFE3
Refseq NM_015156 (mRNA)
NP_055971 (protein) 		NM_198023 (mRNA)
NP_932140 (protein)
Location Chr 14: 102.13 - 102.26 Mb Chr 12: 111.53 - 111.56 Mb
Pubmed search [1] [2]

REST corepressor 1, also known as RCOR1, is a human gene.[1]


The RCOR gene encodes a functional corepressor required for regulation of neural-specific gene expression.[supplied by OMIM][1]


References

  1. ↑ 1.0 1.1 Entrez Gene: RCOR1 REST corepressor 1.

Further reading

  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223-9. PMID 7584044.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
  • Andrés ME, Burger C, Peral-Rubio MJ, et al. (1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9873-8. PMID 10449787.
  • Grimes JA, Nielsen SJ, Battaglioli E, et al. (2000). "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.". J. Biol. Chem. 275 (13): 9461-7. PMID 10734093.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
  • Humphrey GW, Wang Y, Russanova VR, et al. (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.". J. Biol. Chem. 276 (9): 6817-24. doi:10.1074/jbc.M007372200. PMID 11102443.
  • You A, Tong JK, Grozinger CM, Schreiber SL (2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex.". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454-8. doi:10.1073/pnas.98.4.1454. PMID 11171972.
  • Ballas N, Battaglioli E, Atouf F, et al. (2001). "Regulation of neuronal traits by a novel transcriptional complex.". Neuron 31 (3): 353-65. PMID 11516394.
  • Hakimi MA, Bochar DA, Chenoweth J, et al. (2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420-5. doi:10.1073/pnas.112008599. PMID 12032298.
  • Battaglioli E, Andrés ME, Rose DW, et al. (2002). "REST repression of neuronal genes requires components of the hSWI.SNF complex.". J. Biol. Chem. 277 (43): 41038-45. doi:10.1074/jbc.M205691200. PMID 12192000.
  • Lunyak VV, Burgess R, Prefontaine GG, et al. (2002). "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.". Science 298 (5599): 1747-52. doi:10.1126/science.1076469. PMID 12399542.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Hakimi MA, Dong Y, Lane WS, et al. (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.". J. Biol. Chem. 278 (9): 7234-9. doi:10.1074/jbc.M208992200. PMID 12493763.
  • Iwase S, Januma A, Miyamoto K, et al. (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.". Biochem. Biophys. Res. Commun. 322 (2): 601-8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
  • Gu H, Liang Y, Mandel G, Roizman B (2005). "Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells.". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7571-6. doi:10.1073/pnas.0502658102. PMID 15897453.
  • Lee MG, Wynder C, Cooch N, Shiekhattar R (2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation.". Nature 437 (7057): 432-5. doi:10.1038/nature04021. PMID 16079794.
  • Shi YJ, Matson C, Lan F, et al. (2005). "Regulation of LSD1 histone demethylase activity by its associated factors.". Mol. Cell 19 (6): 857-64. doi:10.1016/j.molcel.2005.08.027. PMID 16140033.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391-6. doi:10.1073/pnas.0507066103. PMID 16565220.
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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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