EPHA8: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Ephrin type-A receptor 8''' is a [[protein]] that in humans is encoded by the ''EPHA8'' [[gene]].<ref name="pmid1648701">{{cite journal | vauthors = Chan J, Watt VM | title = eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases | journal = Oncogene | volume = 6 | issue = 6 | pages = 1057–61 | date = Aug 1991 | pmid = 1648701 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EPHA8 EPH receptor A8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2046| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_EPHA8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ucv.
| PDB = {{PDB2|1ucv}}, {{PDB2|1x5l}}
| Name = EPH receptor A8
| HGNCid = 3391
| Symbol = EPHA8
| AltSymbols =; EEK; HEK3; KIAA1459
| OMIM = 176945
| ECnumber = 
| Homologene = 22436
| MGIid = 109378
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005003 |text = ephrin receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2046
    | Hs_Ensembl = ENSG00000070886
    | Hs_RefseqProtein = NP_001006944
    | Hs_RefseqmRNA = NM_001006943
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 22762591
    | Hs_GenLoc_end = 22802674
    | Hs_Uniprot = P29322
    | Mm_EntrezGene = 13842
    | Mm_Ensembl = ENSMUSG00000028661
    | Mm_RefseqmRNA = NM_007939
    | Mm_RefseqProtein = NP_031965
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 136201495
    | Mm_GenLoc_end = 136228894
    | Mm_Uniprot = Q5DTX7
  }}
}}
'''EPH receptor A8''', also known as '''EPHA8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EPHA8 EPH receptor A8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2046| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.<ref name="entrez">{{cite web | title = Entrez Gene: EPHA8 EPH receptor A8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2046| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
EPHA8 has been shown to [[Protein-protein interaction|interact]] with [[FYN]].<ref name=pmid10498895>{{cite journal | vauthors = Choi S, Park S | title = Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity | journal = Oncogene | volume = 18 | issue = 39 | pages = 5413–22 | date = Sep 1999 | pmid = 10498895 | doi = 10.1038/sj.onc.1202917 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Flanagan JG, Vanderhaeghen P | title = The ephrins and Eph receptors in neural development. | journal = Annu. Rev. Neurosci. | volume = 21 | issue =  | pages = 309–45 | year = 1998 | pmid = 9530499 | doi = 10.1146/annurev.neuro.21.1.309 }}
| citations =
* {{cite journal | vauthors = Holland SJ, Peles E, Pawson T, Schlessinger J | title = Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta. | journal = Curr. Opin. Neurobiol. | volume = 8 | issue = 1 | pages = 117–27 | year = 1998 | pmid = 9568399 | doi = 10.1016/S0959-4388(98)80015-9 }}
*{{cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue=  |pages= 309-45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
* {{cite journal | vauthors = Zhou R | title = The Eph family receptors and ligands. | journal = Pharmacol. Ther. | volume = 77 | issue = 3 | pages = 151–81 | year = 1998 | pmid = 9576626 | doi = 10.1016/S0163-7258(97)00112-5 }}
*{{cite journal | author=Holland SJ, Peles E, Pawson T, Schlessinger J |title=Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta. |journal=Curr. Opin. Neurobiol. |volume=8 |issue= 1 |pages= 117-27 |year= 1998 |pmid= 9568399 |doi= }}
* {{cite journal | vauthors = Holder N, Klein R | title = Eph receptors and ephrins: effectors of morphogenesis. | journal = Development | volume = 126 | issue = 10 | pages = 2033–44 | year = 1999 | pmid = 10207129 | doi =  }}
*{{cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151-81 |year= 1998 |pmid= 9576626 |doi= }}
* {{cite journal | vauthors = Wilkinson DG | title = Eph receptors and ephrins: regulators of guidance and assembly. | journal = Int. Rev. Cytol. | volume = 196 | issue =  | pages = 177–244 | year = 2000 | pmid = 10730216 | doi = 10.1016/S0074-7696(00)96005-4 }}
*{{cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033-44 |year= 1999 |pmid= 10207129 |doi=  }}
* {{cite journal | vauthors = Xu Q, Mellitzer G, Wilkinson DG | title = Roles of Eph receptors and ephrins in segmental patterning. | journal = Philos. Trans. R. Soc. Lond. B Biol. Sci. | volume = 355 | issue = 1399 | pages = 993–1002 | year = 2001 | pmid = 11128993 | pmc = 1692797 | doi = 10.1098/rstb.2000.0635 }}
*{{cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue=  |pages= 177-244 |year= 2000 |pmid= 10730216 |doi= }}
* {{cite journal | vauthors = Wilkinson DG | title = Multiple roles of EPH receptors and ephrins in neural development. | journal = Nat. Rev. Neurosci. | volume = 2 | issue = 3 | pages = 155–64 | year = 2001 | pmid = 11256076 | doi = 10.1038/35058515 }}
*{{cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993-1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 }}
* {{cite journal | vauthors = Nakamoto T, Kain KH, Ginsberg MH | title = Neurobiology: New connections between integrins and axon guidance. | journal = Curr. Biol. | volume = 14 | issue = 3 | pages = R121–3 | year = 2004 | pmid = 14986683 | doi = 10.1016/j.cub.2004.01.020 }}
*{{cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155-64 |year= 2001 |pmid= 11256076 |doi= }}
* {{cite journal | vauthors = Yamaguchi Y, Pasquale EB | title = Eph receptors in the adult brain. | journal = Curr. Opin. Neurobiol. | volume = 14 | issue = 3 | pages = 288–96 | year = 2004 | pmid = 15194108 | doi = 10.1016/j.conb.2004.04.003 }}
*{{cite journal | author=Nakamoto T, Kain KH, Ginsberg MH |title=Neurobiology: New connections between integrins and axon guidance. |journal=Curr. Biol. |volume=14 |issue= 3 |pages= R121-3 |year= 2004 |pmid= 14986683 |doi= }}
* {{cite journal | vauthors = Murai KK, Pasquale EB | title = Eph receptors, ephrins, and synaptic function. | journal = The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry | volume = 10 | issue = 4 | pages = 304–14 | year = 2004 | pmid = 15271258 | doi = 10.1177/1073858403262221 }}
*{{cite journal | author=Yamaguchi Y, Pasquale EB |title=Eph receptors in the adult brain. |journal=Curr. Opin. Neurobiol. |volume=14 |issue= 3 |pages= 288-96 |year= 2004 |pmid= 15194108 |doi= 10.1016/j.conb.2004.04.003 }}
* {{cite journal | vauthors = Park S, Sánchez MP | title = The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. | journal = Oncogene | volume = 14 | issue = 5 | pages = 533–42 | year = 1997 | pmid = 9053851 | doi = 10.1038/sj.onc.1200857 }}
*{{cite journal | author=Murai KK, Pasquale EB |title=Eph receptors, ephrins, and synaptic function. |journal=The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry |volume=10 |issue= 4 |pages= 304-14 |year= 2004 |pmid= 15271258 |doi= 10.1177/1073858403262221 }}
* {{cite journal | vauthors = Park S, Frisén J, Barbacid M | title = Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. | journal = EMBO J. | volume = 16 | issue = 11 | pages = 3106–14 | year = 1997 | pmid = 9214628 | pmc = 1169929 | doi = 10.1093/emboj/16.11.3106 }}
*{{cite journal | author=Chan J, Watt VM |title=eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases. |journal=Oncogene |volume=6 |issue= 6 |pages= 1057-61 |year= 1991 |pmid= 1648701 |doi=  }}
* {{cite journal | vauthors = Ephnomenclaturecommittee, | title = Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. | journal = Cell | volume = 90 | issue = 3 | pages = 403–4 | year = 1997 | pmid = 9267020 | doi = 10.1016/S0092-8674(00)80500-0 }}
*{{cite journal  | author=Park S, Sánchez MP |title=The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. |journal=Oncogene |volume=14 |issue= 5 |pages= 533-42 |year= 1997 |pmid= 9053851 |doi= 10.1038/sj.onc.1200857 }}
* {{cite journal | vauthors = Lemke G | title = A coherent nomenclature for Eph receptors and their ligands. | journal = Mol. Cell. Neurosci. | volume = 9 | issue = 5–6 | pages = 331–2 | year = 1998 | pmid = 9361271 | doi = 10.1006/mcne.1997.0630 }}
*{{cite journal | author=Park S, Frisén J, Barbacid M |title=Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. |journal=EMBO J. |volume=16 |issue= 11 |pages= 3106-14 |year= 1997 |pmid= 9214628 |doi= 10.1093/emboj/16.11.3106 }}
* {{cite journal | vauthors = Choi S, Park S | title = Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. | journal = Oncogene | volume = 18 | issue = 39 | pages = 5413–22 | year = 1999 | pmid = 10498895 | doi = 10.1038/sj.onc.1202917 }}
*{{cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403-4 |year= 1997 |pmid= 9267020 |doi= }}
*{{cite journal | author=Lemke G |title=A coherent nomenclature for Eph receptors and their ligands. |journal=Mol. Cell. Neurosci. |volume=9 |issue= 5-6 |pages= 331-2 |year= 1998 |pmid= 9361271 |doi= 10.1006/mcne.1997.0630 }}
*{{cite journal | author=Choi S, Park S |title=Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. |journal=Oncogene |volume=18 |issue= 39 |pages= 5413-22 |year= 1999 |pmid= 10498895 |doi= 10.1038/sj.onc.1202917 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=2046}}
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{{Tyrosine kinases}}
{{Enzymes}}
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[[Category:Tyrosine kinase receptors]]
 
 
{{gene-1-stub}}

Latest revision as of 05:02, 25 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.[1][2]

Function

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.[2]

Interactions

EPHA8 has been shown to interact with FYN.[3]

References

  1. ↑ Chan J, Watt VM (Aug 1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene. 6 (6): 1057–61. PMID 1648701.
  2. ↑ 2.0 2.1 "Entrez Gene: EPHA8 EPH receptor A8".
  3. ↑ Choi S, Park S (Sep 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895.

Further reading


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