ZNF202: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein 202''' is a [[transcription factor]] first associated with [[breast cancer]]. It is a [[protein]] that, in humans, is encoded by the ''ZNF202'' [[gene]].<ref name="pmid9790754">{{cite journal | vauthors = Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M | title = Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins | journal = Genomics | volume = 52 | issue = 3 | pages = 358–62 | date = Sep 1998 | pmid = 9790754 | pmc =  | doi = 10.1006/geno.1998.5419 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNF202 zinc finger protein 202| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7753| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Zinc finger protein 202
| HGNCid = 12994
| Symbol = ZNF202
| AltSymbols =; ZKSCAN10
| OMIM = 603430
| ECnumber = 
| Homologene = 68317
| MGIid = 1933401
| GeneAtlas_image1 = PBB_GE_ZNF202_204327_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ZNF202_204329_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003704 |text = specific RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7753
    | Hs_Ensembl = ENSG00000166261
    | Hs_RefseqProtein = NP_003446
    | Hs_RefseqmRNA = NM_003455
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 123100207
    | Hs_GenLoc_end = 123117573
    | Hs_Uniprot = O95125
    | Mm_EntrezGene = 80902
    | Mm_Ensembl = ENSMUSG00000025602
    | Mm_RefseqmRNA = NM_030713
    | Mm_RefseqProtein = NP_109638
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 39942897
    | Mm_GenLoc_end = 39963762
    | Mm_Uniprot = 
  }}
}}
'''Zinc finger protein 202''', also known as '''ZNF202''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZNF202 zinc finger protein 202| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7753| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Variants of this protein have been discovered to be strongly associated with [[coronary heart disease]] and [[atherosclerosis]].
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite book | title=Zinc finger proteins: from atomic contact to cellular function | series=Molecular biology intelligence unit | first1=Shiro | last1=Iuchi | first2=Natalie | last2=Kuldell | publisher=シュプリンガー・ジャパン株式会社 | year=2005 | isbn=0-306-48229-0 | page=161 }}
| citations =
* {{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = International Journal of Cancer | volume = 83 | issue = 4 | pages = 456–64 | date = Nov 1999 | pmid = 10508479 | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
*{{cite journal  | author=Monaco C, Helmer Citterich M, Caprini E, ''et al.'' |title=Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins. |journal=Genomics |volume=52 |issue= 3 |pages= 358-62 |year= 1998 |pmid= 9790754 |doi= 10.1006/geno.1998.5419 }}
* {{cite journal | vauthors = Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S | title = The SCAN domain mediates selective oligomerization | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 17173–9 | date = Jun 2000 | pmid = 10747874 | doi = 10.1074/jbc.M000119200 }}
*{{cite journal | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi= }}
* {{cite journal | vauthors = Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, Kehrer R, Frodsham M, Schumacher C, Beluch M, Honer C, Skolnick M, Ballinger D, Bowen BR | title = A broad role for the zinc finger protein ZNF202 in human lipid metabolism | journal = The Journal of Biological Chemistry | volume = 275 | issue = 21 | pages = 15685–90 | date = May 2000 | pmid = 10748193 | doi = 10.1074/jbc.M910152199 }}
*{{cite journal | author=Schumacher C, Wang H, Honer C, ''et al.'' |title=The SCAN domain mediates selective oligomerization. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 17173-9 |year= 2000 |pmid= 10747874 |doi= 10.1074/jbc.M000119200 }}
* {{cite journal | vauthors = Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G | title = The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux | journal = The Journal of Biological Chemistry | volume = 276 | issue = 15 | pages = 12427–33 | date = Apr 2001 | pmid = 11279031 | doi = 10.1074/jbc.M100218200 }}
*{{cite journal | author=Wagner S, Hess MA, Ormonde-Hanson P, ''et al.'' |title=A broad role for the zinc finger protein ZNF202 in human lipid metabolism. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 15685-90 |year= 2000 |pmid= 10748193 |doi= 10.1074/jbc.M910152199 }}
* {{cite journal | vauthors = Babb R, Bowen BR | title = SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain | journal = The Biochemical Journal | volume = 370 | issue = Pt 2 | pages = 719–27 | date = Mar 2003 | pmid = 12444922 | pmc = 1223195 | doi = 10.1042/BJ20021378 }}
*{{cite journal | author=Porsch-Ozcurumez M, Langmann T, Heimerl S, ''et al.'' |title=The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 12427-33 |year= 2001 |pmid= 11279031 |doi= 10.1074/jbc.M100218200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network|authorlink30=Huda Zoghbi | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Babb R, Bowen BR |title=SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain. |journal=Biochem. J. |volume=370 |issue= Pt 2 |pages= 719-27 |year= 2003 |pmid= 12444922 |doi= 10.1042/BJ20021378 }}
* {{cite journal | vauthors = Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A | title = Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study | journal = Atherosclerosis | volume = 188 | issue = 1 | pages = 43–50 | date = Sep 2006 | pmid = 16289551 | doi = 10.1016/j.atherosclerosis.2005.10.014 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A | title = Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population | journal = Journal of Lipid Research | volume = 47 | issue = 5 | pages = 944–52 | date = May 2006 | pmid = 16467280 | doi = 10.1194/jlr.M500521-JLR200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Stene MC, Frikke-Schmidt R, Nordestgaard BG, ''et al.'' |title=Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study. |journal=Atherosclerosis |volume=188 |issue= 1 |pages= 43-50 |year= 2006 |pmid= 16289551 |doi= 10.1016/j.atherosclerosis.2005.10.014 }}
*{{cite journal | author=Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A |title=Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population. |journal=J. Lipid Res. |volume=47 |issue= 5 |pages= 944-52 |year= 2006 |pmid= 16467280 |doi= 10.1194/jlr.M500521-JLR200 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|ZNF202+protein,+human}}
* {{MeshName|ZNF202+protein,+human}}


{{NLM content}}
{{Transcription factors|g2}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
[[Category:Oncology]]
[[Category:Proteins]]
 
 
{{gene-11-stub}}

Latest revision as of 22:09, 25 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.[1][2]

Clinical significance

Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.

References

  1. ↑ Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M (Sep 1998). "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins". Genomics. 52 (3): 358–62. doi:10.1006/geno.1998.5419. PMID 9790754.
  2. ↑ "Entrez Gene: ZNF202 zinc finger protein 202".

Further reading

  • Iuchi, Shiro; Kuldell, Natalie (2005). Zinc finger proteins: from atomic contact to cellular function. Molecular biology intelligence unit. シュプリンガー・ジャパン株式会社. p. 161. ISBN 0-306-48229-0.
  • Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
  • Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
  • Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, Kehrer R, Frodsham M, Schumacher C, Beluch M, Honer C, Skolnick M, Ballinger D, Bowen BR (May 2000). "A broad role for the zinc finger protein ZNF202 in human lipid metabolism". The Journal of Biological Chemistry. 275 (21): 15685–90. doi:10.1074/jbc.M910152199. PMID 10748193.
  • Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G (Apr 2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry. 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031.
  • Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A (Sep 2006). "Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study". Atherosclerosis. 188 (1): 43–50. doi:10.1016/j.atherosclerosis.2005.10.014. PMID 16289551.
  • Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A (May 2006). "Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population". Journal of Lipid Research. 47 (5): 944–52. doi:10.1194/jlr.M500521-JLR200. PMID 16467280.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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