Y box binding protein 1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Y box binding protein 1''' also known as '''Y-box transcription factor''' or '''nuclease-sensitive element-binding protein 1''' is a [[protein]] that in humans is encoded by the ''YBX1'' [[gene]].<ref>{{cite web | title = Entrez Gene: YBX1 Y box binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4904| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{GNF_Protein_box
| image = PBB_Protein_YBX1_image.jpg
| image_source = [[Protein Data Bank|PDB]] rendering based on 1h95.
| PDB = {{PDB2|1h95}}
| Name = Y box binding protein 1
| HGNCid = 8014
| Symbol = YBX1
| AltSymbols =; BP-8; CSDA2; CSDB; DBPB; MDR-NF1; MGC104858; MGC110976; MGC117250; NSEP-1; NSEP1; YB-1; YB1
| OMIM = 154030
| ECnumber = 
| Homologene = 88707
| MGIid = 
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0003697 |text = single-stranded DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4904
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_004550
    | Hs_RefseqmRNA = NM_004559
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Y box binding protein 1''', officially known as '''YBX1''', but commonly referred to as "YB-1" by researchers, is a human [[protein]].<ref>{{cite web | title = Entrez Gene: YBX1 Y box binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4904| accessdate = }}</ref> Current research is examining its involvement in cancer, and particularly in the [[metastasis]] of cancerous cells or prevention thereof.


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
YBX1 is a potential drug target in cancer therapy.<ref name="Lage_2008">{{cite journal |vauthors=Lage H, Surowiak P, Holm PS | title = [YB-1 as a potential target in cancer therapy] | language = German | journal = Pathologe | volume = 29 Suppl 2 | issue = | pages = 187–90 |date=November 2008 | pmid = 18773210 | doi = 10.1007/s00292-008-1030-2  }}</ref> YB-1 helps the replication of [[adenovirus]] type 5, a commonly used vector in [[gene therapy]].<ref name="Lage_2008"/> Thus, YB-1 can cause an [[oncolytic virus|"oncolytic" effect]] in YB-1 positive cancer cells treated with adenoviruses
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== Interactions ==
{{reflist|2}}


==Further reading==
Y box binding protein 1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[ANKRD2]],<ref name = pmid15136035>{{cite journal |vauthors=Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G | title = The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle | journal = J. Mol. Biol. | volume = 339 | issue = 2 | pages = 313–25 | year = 2004 | pmid = 15136035 | doi = 10.1016/j.jmb.2004.03.071 }}</ref>
* [[CTCF]],<ref name = pmid10906122>{{cite journal |vauthors=Chernukhin IV, Shamsuddin S, Robinson AF, Carne AF, Paul A, El-Kady AI, Lobanenkov VV, Klenova EM | title = Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF | journal = J. Biol. Chem. | volume = 275 | issue = 38 | pages = 29915–21 | year = 2000 | pmid = 10906122 | doi = 10.1074/jbc.M001538200 }}</ref>
* [[P53]],<ref name = pmid15136035/><ref name = pmid11175333>{{cite journal |vauthors=Okamoto T, Izumi H, Imamura T, Takano H, Ise T, Uchiumi T, Kuwano M, Kohno K | title = Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression | journal = Oncogene | volume = 19 | issue = 54 | pages = 6194–202 | year = 2000 | pmid = 11175333 | doi = 10.1038/sj.onc.1204029 }}</ref>
* [[PCNA]],<ref name = pmid9927044>{{cite journal |vauthors=Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K | title = Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen | journal = Cancer Res. | volume = 59 | issue = 2 | pages = 342–6 | year = 1999 | pmid = 9927044 | doi = }}</ref>
* [[RBBP6]],<ref name = pmid18851979>{{cite journal |vauthors=Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ | title = RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1 | journal = J. Mol. Biol. | volume = 384 | issue = 4 | pages = 908–16 | year = 2008 | pmid = 18851979 | doi = 10.1016/j.jmb.2008.09.060 }}</ref>  and
* [[SFRS9]].<ref name = pmid12604611>{{cite journal |vauthors=Raffetseder U, Frye B, Rauen T, Jürchott K, Royer HD, Jansen PL, Mertens PR | title = Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection | journal = J. Biol. Chem. | volume = 278 | issue = 20 | pages = 18241–8 | year = 2003 | pmid = 12604611 | doi = 10.1074/jbc.M212518200 }}</ref>
{{Div col end}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Kolluri R, Torrey TA, Kinniburgh AJ |title=A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif. |journal=Nucleic Acids Res. |volume=20 |issue= 1 |pages= 111–6 |year= 1992 |pmid= 1738588 |doi=10.1093/nar/20.1.111  | pmc=310333 }}
| citations =
*{{cite journal  |vauthors=Kolluri R, Kinniburgh AJ |title=Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein. |journal=Nucleic Acids Res. |volume=19 |issue= 17 |pages= 4771 |year= 1991 |pmid= 1891370 |doi=10.1093/nar/19.17.4771  | pmc=328725 }}
*{{cite journal  | author=Kolluri R, Torrey TA, Kinniburgh AJ |title=A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif. |journal=Nucleic Acids Res. |volume=20 |issue= 1 |pages= 111-6 |year= 1992 |pmid= 1738588 |doi=  }}
*{{cite journal   |vauthors=Sakura H, Maekawa T, Imamoto F, etal |title=Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology. |journal=Gene |volume=73 |issue= 2 |pages= 499–507 |year= 1989 |pmid= 2977358 |doi=10.1016/0378-1119(88)90514-8 }}
*{{cite journal  | author=Kolluri R, Kinniburgh AJ |title=Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein. |journal=Nucleic Acids Res. |volume=19 |issue= 17 |pages= 4771 |year= 1991 |pmid= 1891370 |doi=  }}
*{{cite journal   |vauthors=Didier DK, Schiffenbauer J, Woulfe SL, etal |title=Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 19 |pages= 7322–6 |year= 1988 |pmid= 3174636 |doi=10.1073/pnas.85.19.7322  | pmc=282178 }}
*{{cite journal | author=Sakura H, Maekawa T, Imamoto F, ''et al.'' |title=Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology. |journal=Gene |volume=73 |issue= 2 |pages= 499-507 |year= 1989 |pmid= 2977358 |doi=  }}
*{{cite journal  |vauthors=Kudo S, Mattei MG, Fukuda M |title=Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain. |journal=Eur. J. Biochem. |volume=231 |issue= 1 |pages= 72–82 |year= 1995 |pmid= 7628487 |doi=10.1111/j.1432-1033.1995.tb20672.x  }}
*{{cite journal | author=Didier DK, Schiffenbauer J, Woulfe SL, ''et al.'' |title=Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 19 |pages= 7322-6 |year= 1988 |pmid= 3174636 |doi=  }}
*{{cite journal  |vauthors=Lloberas J, Maki RA, Celada A |title=Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5092–9 |year= 1995 |pmid= 7651426 |doi= | pmc=230756 }}
*{{cite journal  | author=Kudo S, Mattei MG, Fukuda M |title=Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain. |journal=Eur. J. Biochem. |volume=231 |issue= 1 |pages= 72-82 |year= 1995 |pmid= 7628487 |doi= }}
*{{cite journal   |vauthors=Chen NN, Chang CF, Gallia GL, etal |title=Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 4 |pages= 1087–91 |year= 1995 |pmid= 7862639 |doi=10.1073/pnas.92.4.1087  | pmc=42642 }}
*{{cite journal  | author=Lloberas J, Maki RA, Celada A |title=Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 5092-9 |year= 1995 |pmid= 7651426 |doi=  }}
*{{cite journal  |vauthors=Horwitz EM, Maloney KA, Ley TJ |title=A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes. |journal=J. Biol. Chem. |volume=269 |issue= 19 |pages= 14130–9 |year= 1994 |pmid= 8188694 |doi=  }}
*{{cite journal | author=Chen NN, Chang CF, Gallia GL, ''et al.'' |title=Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 4 |pages= 1087-91 |year= 1995 |pmid= 7862639 |doi=  }}
*{{cite journal   |vauthors=Kashanchi F, Duvall JF, Dittmer J, etal |title=Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression. |journal=J. Virol. |volume=68 |issue= 1 |pages= 561–5 |year= 1994 |pmid= 8254772 |doi= | pmc=236322 }}
*{{cite journal  | author=Horwitz EM, Maloney KA, Ley TJ |title=A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes. |journal=J. Biol. Chem. |volume=269 |issue= 19 |pages= 14130-9 |year= 1994 |pmid= 8188694 |doi=  }}
*{{cite journal   |vauthors=Makino Y, Ohga T, Toh S, etal |title=Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter. |journal=Nucleic Acids Res. |volume=24 |issue= 10 |pages= 1873–8 |year= 1996 |pmid= 8657568 |doi=10.1093/nar/24.10.1873  | pmc=145870 }}
*{{cite journal | author=Kashanchi F, Duvall JF, Dittmer J, ''et al.'' |title=Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression. |journal=J. Virol. |volume=68 |issue= 1 |pages= 561-5 |year= 1994 |pmid= 8254772 |doi=  }}
*{{cite journal   |vauthors=Funke B, Zuleger B, Benavente R, etal |title=The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. |journal=Nucleic Acids Res. |volume=24 |issue= 19 |pages= 3821–8 |year= 1996 |pmid= 8871564 |doi=10.1093/nar/24.19.3821  | pmc=146158 }}
*{{cite journal | author=Makino Y, Ohga T, Toh S, ''et al.'' |title=Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter. |journal=Nucleic Acids Res. |volume=24 |issue= 10 |pages= 1873-8 |year= 1996 |pmid= 8657568 |doi=  }}
*{{cite journal   |vauthors=Koike K, Uchiumi T, Ohga T, etal |title=Nuclear translocation of the Y-box binding protein by ultraviolet irradiation. |journal=FEBS Lett. |volume=417 |issue= 3 |pages= 390–4 |year= 1998 |pmid= 9409758 |doi=10.1016/S0014-5793(97)01296-9 }}
*{{cite journal | author=Funke B, Zuleger B, Benavente R, ''et al.'' |title=The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. |journal=Nucleic Acids Res. |volume=24 |issue= 19 |pages= 3821-8 |year= 1996 |pmid= 8871564 |doi=  }}
*{{cite journal   |vauthors=Toh S, Nakamura T, Ohga T, etal |title=Genomic organization of the human Y-box protein (YB-1) gene. |journal=Gene |volume=206 |issue= 1 |pages= 93–7 |year= 1998 |pmid= 9461420 |doi=10.1016/S0378-1119(97)00570-2  }}
*{{cite journal | author=Koike K, Uchiumi T, Ohga T, ''et al.'' |title=Nuclear translocation of the Y-box binding protein by ultraviolet irradiation. |journal=FEBS Lett. |volume=417 |issue= 3 |pages= 390-4 |year= 1998 |pmid= 9409758 |doi=  }}
*{{cite journal  |vauthors=Sawaya BE, Khalili K, Amini S |title=Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat. | series=79 |journal=J. Gen. Virol. |volume=( Pt 2) |issue=  |pages= 239–46 |year= 1998 |pmid= 9472608 |doi=  }}
*{{cite journal | author=Toh S, Nakamura T, Ohga T, ''et al.'' |title=Genomic organization of the human Y-box protein (YB-1) gene. |journal=Gene |volume=206 |issue= 1 |pages= 93-7 |year= 1998 |pmid= 9461420 |doi= }}
*{{cite journal  |vauthors=Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH |title=A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32957–65 |year= 1999 |pmid= 9830047 |doi=10.1074/jbc.273.49.32957 }}
*{{cite journal  | author=Sawaya BE, Khalili K, Amini S |title=Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat. |journal=J. Gen. Virol. |volume=79 ( Pt 2) |issue=  |pages= 239-46 |year= 1998 |pmid= 9472608 |doi=  }}
*{{cite journal   |vauthors=Ise T, Nagatani G, Imamura T, etal |title=Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen. |journal=Cancer Res. |volume=59 |issue= 2 |pages= 342–6 |year= 1999 |pmid= 9927044 |doi=  }}
*{{cite journal  | author=Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH |title=A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32957-65 |year= 1999 |pmid= 9830047 |doi=  }}
*{{cite journal  |vauthors=Safak M, Gallia GL, Khalili K |title=Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 2712–23 |year= 1999 |pmid= 10082537 |doi= 10.1128/mcb.19.4.2712| pmc=84064 }}
*{{cite journal | author=Ise T, Nagatani G, Imamura T, ''et al.'' |title=Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen. |journal=Cancer Res. |volume=59 |issue= 2 |pages= 342-6 |year= 1999 |pmid= 9927044 |doi=  }}
*{{cite journal   |vauthors=Kelm RJ, Cogan JG, Elder PK, etal |title=Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14238–45 |year= 1999 |pmid= 10318844 |doi=10.1074/jbc.274.20.14238 }}
*{{cite journal  | author=Safak M, Gallia GL, Khalili K |title=Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 2712-23 |year= 1999 |pmid= 10082537 |doi=  }}
*{{cite journal  |vauthors=Safak M, Gallia GL, Ansari SA, Khalili K |title=Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen. |journal=J. Virol. |volume=73 |issue= 12 |pages= 10146–57 |year= 1999 |pmid= 10559330 |doi= | pmc=113067 }}
*{{cite journal | author=Kelm RJ, Cogan JG, Elder PK, ''et al.'' |title=Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14238-45 |year= 1999 |pmid= 10318844 |doi=  }}
*{{cite journal   |vauthors=Ansari SA, Safak M, Gallia GL, etal |title=Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity. | series=80 |journal=J. Gen. Virol. |volume=( Pt 10) |issue=  |pages= 2629–38 |year= 1999 |pmid= 10573156 |doi=  }}
*{{cite journal  | author=Safak M, Gallia GL, Ansari SA, Khalili K |title=Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen. |journal=J. Virol. |volume=73 |issue= 12 |pages= 10146-57 |year= 1999 |pmid= 10559330 |doi=  }}
*{{cite journal  |vauthors=Basaki Y, Hosoi F, Oda Y, etal |title=Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells. |journal=Oncogene |volume=26 |issue=  19|pages= 2736–46 |year= 2007 |pmid= 17072343 |doi=10.1038/sj.onc.1210084  }}
*{{cite journal | author=Ansari SA, Safak M, Gallia GL, ''et al.'' |title=Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity. |journal=J. Gen. Virol. |volume=80 ( Pt 10) |issue=  |pages= 2629-38 |year= 1999 |pmid= 10573156 |doi=  }}
}}
{{refend}}
{{refend}}


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Revision as of 22:12, 18 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.[1]

Clinical significance

YBX1 is a potential drug target in cancer therapy.[2] YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy.[2] Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses

Interactions

Y box binding protein 1 has been shown to interact with:

References

  1. ↑ "Entrez Gene: YBX1 Y box binding protein 1".
  2. ↑ 2.0 2.1 Lage H, Surowiak P, Holm PS (November 2008). "[YB-1 as a potential target in cancer therapy]". Pathologe (in German). 29 Suppl 2: 187–90. doi:10.1007/s00292-008-1030-2. PMID 18773210.
  3. ↑ 3.0 3.1 Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. PMID 15136035.
  4. ↑ Chernukhin IV, Shamsuddin S, Robinson AF, Carne AF, Paul A, El-Kady AI, Lobanenkov VV, Klenova EM (2000). "Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF". J. Biol. Chem. 275 (38): 29915–21. doi:10.1074/jbc.M001538200. PMID 10906122.
  5. ↑ Okamoto T, Izumi H, Imamura T, Takano H, Ise T, Uchiumi T, Kuwano M, Kohno K (2000). "Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression". Oncogene. 19 (54): 6194–202. doi:10.1038/sj.onc.1204029. PMID 11175333.
  6. ↑ Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6. PMID 9927044.
  7. ↑ Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. 384 (4): 908–16. doi:10.1016/j.jmb.2008.09.060. PMID 18851979.
  8. ↑ Raffetseder U, Frye B, Rauen T, Jürchott K, Royer HD, Jansen PL, Mertens PR (2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi:10.1074/jbc.M212518200. PMID 12604611.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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