SOX4
| SRY (sex determining region Y)-box 4 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SOX4 ; EVI16 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2338 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SOX4 201417 at tn.png | |||||||||||
| File:PBB GE SOX4 201416 at tn.png | |||||||||||
| File:PBB GE SOX4 201418 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
SRY (sex determining region Y)-box 4, also known as SOX4, is a human gene.[1]
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.[1]
See also
References
Further reading
- Kamachi Y, Uchikawa M, Kondoh H (2000). "Pairing SOX off: with partners in the regulation of embryonic development". Trends Genet. 16 (4): 182–7. PMID 10729834.
- Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators". Dev. Biol. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752.
- Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Curr. Opin. Genet. Dev. 12 (4): 441–6. PMID 12100890.
- Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Dev. Cell. 3 (2): 167–70. PMID 12194848.
- Denny P, Swift S, Brand N; et al. (1992). "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Res. 20 (11): 2887. PMID 1614875.
- Wotton D, Lake RA, Farr CJ, Owen MJ (1995). "The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer". J. Biol. Chem. 270 (13): 7515–22. PMID 7706298.
- Farr CJ, Easty DJ, Ragoussis J; et al. (1994). "Characterization and mapping of the human SOX4 gene". Mamm. Genome. 4 (10): 577–84. PMID 8268656.
- van de Wetering M, Oosterwegel M, van Norren K, Clevers H (1993). "Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes". EMBO J. 12 (10): 3847–54. PMID 8404853.
- van Houte LP, Chuprina VP, van der Wetering M; et al. (1996). "Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4". J. Biol. Chem. 270 (51): 30516–24. PMID 8530483.
- Critcher R, Stitson RN, Wade-Martins R; et al. (1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet. Cell Genet. 81 (3–4): 294–5. PMID 9730625.
- Ahn SG, Cho GH, Jeong SY; et al. (1999). "Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells". Biochem. Biophys. Res. Commun. 260 (1): 216–21. doi:10.1006/bbrc.1999.0856. PMID 10381369.
- van Beest M, Dooijes D, van De Wetering M; et al. (2000). "Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs". J. Biol. Chem. 275 (35): 27266–73. doi:10.1074/jbc.M004102200. PMID 10867006.
- Reppe S, Rian E, Jemtland R; et al. (2001). "Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells". J. Bone Miner. Res. 15 (12): 2402–12. PMID 11127205.
- Geijsen N, Uings IJ, Pals C; et al. (2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science. 293 (5532): 1136–8. doi:10.1126/science.1059157. PMID 11498591.
- Lee CJ, Appleby VJ, Orme AT; et al. (2003). "Differential expression of SOX4 and SOX11 in medulloblastoma". J. Neurooncol. 57 (3): 201–14. PMID 12125983.
- Ahn SG, Kim HS, Jeong SW; et al. (2003). "Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2)". Exp. Mol. Med. 34 (3): 243–9. PMID 12216117.
External links
- SOX4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.