SOX4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Transcription factor SOX-4''' is a [[protein]] that in humans is encoded by the ''SOX4'' [[gene]].<ref name="pmid8268656">{{cite journal | vauthors = Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN | title = Characterization and mapping of the human SOX4 gene | journal = Mamm Genome | volume = 4 | issue = 10 | pages = 577–84 | date = January 1994 | pmid = 8268656 | pmc =  | doi = 10.1007/BF00361388 }}</ref><ref name="pmid9730625">{{cite journal | vauthors = Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ | title = Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3 | journal = Cytogenet Cell Genet | volume = 81 | issue = 3–4 | pages = 294–5 | date = October 1998 | pmid = 9730625 | pmc =  | doi = 10.1159/000015052 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SOX4 SRY (sex determining region Y)-box 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6659| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SRY (sex determining region Y)-box 4
| HGNCid = 11200
| Symbol = SOX4
| AltSymbols =; EVI16
| OMIM = 184430
| ECnumber = 
| Homologene = 2338
| MGIid = 98366
| GeneAtlas_image1 = PBB_GE_SOX4_201417_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOX4_201416_at_tn.png
| GeneAtlas_image3 = PBB_GE_SOX4_201418_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0031017 |text = exocrine pancreas development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6659
    | Hs_Ensembl = ENSG00000124766
    | Hs_RefseqProtein = NP_003098
    | Hs_RefseqmRNA = NM_003107
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 21700979
    | Hs_GenLoc_end = 21706829
    | Hs_Uniprot = Q06945
    | Mm_EntrezGene = 20677
    | Mm_Ensembl = ENSMUSG00000076431
    | Mm_RefseqmRNA = NM_009238
    | Mm_RefseqProtein = NP_033264
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 28956384
    | Mm_GenLoc_end = 28961178
    | Mm_Uniprot = Q5SW95
  }}
}}
'''SRY (sex determining region Y)-box 4''', also known as '''SOX4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOX4 SRY (sex determining region Y)-box 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6659| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.<ref name="entrez">{{cite web | title = Entrez Gene: SOX4 SRY (sex determining region Y)-box 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6659| accessdate = }}</ref>
}}


==See also==
Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.<ref name="pmid14982952">{{cite journal | vauthors = Smith E, Sigvardsson M | title = The roles of transcription factors in B lymphocyte commitment, development, and transformation | journal = J. Leukoc. Biol. | volume = 75 | issue = 6 | pages = 973–81 | year = 2004 | pmid = 14982952 | doi = 10.1189/jlb.1103554 }}</ref>
 
== Interactions ==
SOX4 has been shown to [[Protein-protein interaction|interact]] with [[SDCBP]].<ref name=pmid11498591>{{cite journal | vauthors = Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ | title = Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein | journal = [[Science (journal)|Science]] | volume = 293 | issue = 5532 | pages = 1136–8 | date = August 2001 | pmid = 11498591 | doi = 10.1126/science.1059157 }}</ref>
 
== See also ==
* [[SOX genes]]
* [[SOX genes]]


==References==
== References ==
{{reflist|2}}
{{Reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kamachi Y, Uchikawa M, Kondoh H | title = Pairing SOX off: with partners in the regulation of embryonic development | journal = Trends Genet. | volume = 16 | issue = 4 | pages = 182–7 | year = 2000 | pmid = 10729834 | doi = 10.1016/S0168-9525(99)01955-1 }}
| citations =
* {{cite journal | vauthors = Bowles J, Schepers G, Koopman P | title = Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators | journal = Dev. Biol. | volume = 227 | issue = 2 | pages = 239–55 | year = 2001 | pmid = 11071752 | doi = 10.1006/dbio.2000.9883 }}
*{{cite journal | author=Kamachi Y, Uchikawa M, Kondoh H |title=Pairing SOX off: with partners in the regulation of embryonic development. |journal=Trends Genet. |volume=16 |issue= 4 |pages= 182-7 |year= 2000 |pmid= 10729834 |doi= }}
* {{cite journal | vauthors = Wilson M, Koopman P | title = Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators | journal = Curr. Opin. Genet. Dev. | volume = 12 | issue = 4 | pages = 441–6 | year = 2003 | pmid = 12100890 | doi = 10.1016/S0959-437X(02)00323-4 }}
*{{cite journal | author=Bowles J, Schepers G, Koopman P |title=Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. |journal=Dev. Biol. |volume=227 |issue= 2 |pages= 239-55 |year= 2001 |pmid= 11071752 |doi= 10.1006/dbio.2000.9883 }}
* {{cite journal | vauthors = Schepers GE, Teasdale RD, Koopman P | title = Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families | journal = Dev. Cell | volume = 3 | issue = 2 | pages = 167–70 | year = 2002 | pmid = 12194848 | doi = 10.1016/S1534-5807(02)00223-X }}
*{{cite journal | author=Wilson M, Koopman P |title=Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators. |journal=Curr. Opin. Genet. Dev. |volume=12 |issue= 4 |pages= 441-6 |year= 2003 |pmid= 12100890 |doi= }}
* {{cite journal | vauthors = Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A | title = A conserved family of genes related to the testis determining gene, SRY | journal = Nucleic Acids Res. | volume = 20 | issue = 11 | pages = 2887 | year = 1992 | pmid = 1614875 | pmc = 336939 | doi = 10.1093/nar/20.11.2887 }}
*{{cite journal | author=Schepers GE, Teasdale RD, Koopman P |title=Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. |journal=Dev. Cell |volume=3 |issue= 2 |pages= 167-70 |year= 2002 |pmid= 12194848 |doi= }}
* {{cite journal | vauthors = Wotton D, Lake RA, Farr CJ, Owen MJ | title = The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer | journal = J. Biol. Chem. | volume = 270 | issue = 13 | pages = 7515–22 | year = 1995 | pmid = 7706298 | doi = 10.1074/jbc.270.13.7515 }}
*{{cite journal | author=Denny P, Swift S, Brand N, ''et al.'' |title=A conserved family of genes related to the testis determining gene, SRY. |journal=Nucleic Acids Res. |volume=20 |issue= 11 |pages= 2887 |year= 1992 |pmid= 1614875 |doi= }}
* {{cite journal | vauthors = van de Wetering M, Oosterwegel M, van Norren K, Clevers H | title = Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes | journal = EMBO J. | volume = 12 | issue = 10 | pages = 3847–54 | year = 1993 | pmid = 8404853 | pmc = 413668 | doi =  }}
*{{cite journal | author=Wotton D, Lake RA, Farr CJ, Owen MJ |title=The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7515-22 |year= 1995 |pmid= 7706298 |doi= }}
* {{cite journal | vauthors = van Houte LP, Chuprina VP, van der Wetering M, Boelens R, Kaptein R, Clevers H | title = Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4 | journal = J. Biol. Chem. | volume = 270 | issue = 51 | pages = 30516–24 | year = 1996 | pmid = 8530483 | doi = 10.1074/jbc.270.51.30516 }}
*{{cite journal  | author=Farr CJ, Easty DJ, Ragoussis J, ''et al.'' |title=Characterization and mapping of the human SOX4 gene. |journal=Mamm. Genome |volume=4 |issue= 10 |pages= 577-84 |year= 1994 |pmid= 8268656 |doi=  }}
* {{cite journal | vauthors = Ahn SG, Cho GH, Jeong SY, Rhim H, Choi JY, Kim IK | title = Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells | journal = Biochem. Biophys. Res. Commun. | volume = 260 | issue = 1 | pages = 216–21 | year = 1999 | pmid = 10381369 | doi = 10.1006/bbrc.1999.0856 }}
*{{cite journal | author=van de Wetering M, Oosterwegel M, van Norren K, Clevers H |title=Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. |journal=EMBO J. |volume=12 |issue= 10 |pages= 3847-54 |year= 1993 |pmid= 8404853 |doi=  }}
* {{cite journal | vauthors = van Beest M, Dooijes D, van De Wetering M, Kjaerulff S, Bonvin A, Nielsen O, Clevers H | title = Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs | journal = J. Biol. Chem. | volume = 275 | issue = 35 | pages = 27266–73 | year = 2000 | pmid = 10867006 | doi = 10.1074/jbc.M004102200 }}
*{{cite journal | author=van Houte LP, Chuprina VP, van der Wetering M, ''et al.'' |title=Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4. |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30516-24 |year= 1996 |pmid= 8530483 |doi= }}
* {{cite journal | vauthors = Reppe S, Rian E, Jemtland R, Olstad OK, Gautvik VT, Gautvik KM | title = Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells | journal = J. Bone Miner. Res. | volume = 15 | issue = 12 | pages = 2402–12 | year = 2001 | pmid = 11127205 | doi = 10.1359/jbmr.2000.15.12.2402 }}
*{{cite journal  | author=Critcher R, Stitson RN, Wade-Martins R, ''et al.'' |title=Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 294-5 |year= 1998 |pmid= 9730625 |doi=  }}
* {{cite journal | vauthors = Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ | title = Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein | journal = Science | volume = 293 | issue = 5532 | pages = 1136–8 | year = 2001 | pmid = 11498591 | doi = 10.1126/science.1059157 }}
*{{cite journal | author=Ahn SG, Cho GH, Jeong SY, ''et al.'' |title=Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 216-21 |year= 1999 |pmid= 10381369 |doi= 10.1006/bbrc.1999.0856 }}
* {{cite journal | vauthors = Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ | title = Differential expression of SOX4 and SOX11 in medulloblastoma | journal = J. Neurooncol. | volume = 57 | issue = 3 | pages = 201–14 | year = 2003 | pmid = 12125983 | doi = 10.1023/A:1015773818302 }}
*{{cite journal | author=van Beest M, Dooijes D, van De Wetering M, ''et al.'' |title=Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27266-73 |year= 2000 |pmid= 10867006 |doi= 10.1074/jbc.M004102200 }}
* {{cite journal | vauthors = Ahn SG, Kim HS, Jeong SW, Kim BE, Rhim H, Shim JY, Kim JW, Lee JH, Kim IK | title = Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2) | journal = [[Experimental & Molecular Medicine]] | volume = 34 | issue = 3 | pages = 243–9 | year = 2003 | pmid = 12216117 | doi = 10.1038/emm.2002.34 }}
*{{cite journal | author=Reppe S, Rian E, Jemtland R, ''et al.'' |title=Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells. |journal=J. Bone Miner. Res. |volume=15 |issue= 12 |pages= 2402-12 |year= 2001 |pmid= 11127205 |doi= }}
{{Refend}}
*{{cite journal | author=Geijsen N, Uings IJ, Pals C, ''et al.'' |title=Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. |journal=Science |volume=293 |issue= 5532 |pages= 1136-8 |year= 2001 |pmid= 11498591 |doi= 10.1126/science.1059157 }}
*{{cite journal | author=Lee CJ, Appleby VJ, Orme AT, ''et al.'' |title=Differential expression of SOX4 and SOX11 in medulloblastoma. |journal=J. Neurooncol. |volume=57 |issue= 3 |pages= 201-14 |year= 2003 |pmid= 12125983 |doi= }}
*{{cite journal | author=Ahn SG, Kim HS, Jeong SW, ''et al.'' |title=Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2). |journal=Exp. Mol. Med. |volume=34 |issue= 3 |pages= 243-9 |year= 2003 |pmid= 12216117 |doi= }}
}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|SOX4+protein,+human}}
* {{MeshName|SOX4+protein,+human}}


{{NLM content}}
{{Transcription factors|g4}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{Gene-6-stub}}

Revision as of 01:58, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.[1][2][3]

Function

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.[3]

Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.[4]

Interactions

SOX4 has been shown to interact with SDCBP.[5]

See also

References

  1. ↑ Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN (January 1994). "Characterization and mapping of the human SOX4 gene". Mamm Genome. 4 (10): 577–84. doi:10.1007/BF00361388. PMID 8268656.
  2. ↑ Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (October 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625.
  3. ↑ 3.0 3.1 "Entrez Gene: SOX4 SRY (sex determining region Y)-box 4".
  4. ↑ Smith E, Sigvardsson M (2004). "The roles of transcription factors in B lymphocyte commitment, development, and transformation". J. Leukoc. Biol. 75 (6): 973–81. doi:10.1189/jlb.1103554. PMID 14982952.
  5. ↑ Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ (August 2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science. 293 (5532): 1136–8. doi:10.1126/science.1059157. PMID 11498591.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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