RAR-related orphan receptor alpha

RAR-related orphan receptor A
File:PBB Protein RORA image.jpg PDB rendering based on 1n83.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1n83​, 1s0x​
Identifiers
Symbols	RORA ; ROR1; ROR2; MGC119326; MGC119329; NR1F1; ROR3; RZRA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56594
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RORA 210479 s at tn.png
File:PBB GE RORA 210426 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

RAR-related orphan receptor alpha (ROR-alpha), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor encoded by the RORA gene.

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.

Further reading

• Giguère V, Beatty B, Squire J; et al. (1996). "The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9". Genomics. 28 (3): 596–8. doi:10.1006/geno.1995.1197. PMID 7490103.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steinhilber D, Brungs M, Werz O; et al. (1995). "The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes". J. Biol. Chem. 270 (13): 7037–40. PMID 7706239.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Forman BM, Chen J, Blumberg B; et al. (1995). "Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors". Mol. Endocrinol. 8 (9): 1253–61. PMID 7838158.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Becker-André M, André E, DeLamarter JF (1993). "Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences". Biochem. Biophys. Res. Commun. 194 (3): 1371–9. PMID 7916608.CS1 maint: Multiple names: authors list (link)
• Giguère V, Tini M, Flock G; et al. (1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes Dev. 8 (5): 538–53. PMID 7926749.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carlberg C, Hooft van Huijsduijnen R, Staple JK; et al. (1994). "RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers". Mol. Endocrinol. 8 (6): 757–70. PMID 7935491.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.CS1 maint: Multiple names: authors list (link)
• Lau P, Bailey P, Dowhan DH, Muscat GE (1999). "Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD". Nucleic Acids Res. 27 (2): 411–20. PMID 9862959.CS1 maint: Multiple names: authors list (link)
• Atkins GB, Hu X, Guenther MG; et al. (1999). "Coactivators for the orphan nuclear receptor RORalpha". Mol. Endocrinol. 13 (9): 1550–7. PMID 10478845.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meyer T, Kneissel M, Mariani J, Fournier B (2000). "In vitro and in vivo evidence for orphan nuclear receptor RORalpha function in bone metabolism". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9197–202. doi:10.1073/pnas.150246097. PMID 10900268.CS1 maint: Multiple names: authors list (link)
• Gawlas K, Stunnenberg HG (2001). "Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1)". Biochim. Biophys. Acta. 1494 (3): 236–41. PMID 11121580.
• Delerive P, Chin WW, Suen CS (2002). "Identification of Reverb(alpha) as a novel ROR(alpha) target gene". J. Biol. Chem. 277 (38): 35013–8. doi:10.1074/jbc.M202979200. PMID 12114512.CS1 maint: Multiple names: authors list (link)
• Moretti RM, Marelli MM, Motta M, Limonta P (2003). "Role of the orphan nuclear receptor ROR alpha in the control of the metastatic behavior of androgen-independent prostate cancer cells". Oncol. Rep. 9 (5): 1139–43. PMID 12168086.CS1 maint: Multiple names: authors list (link)
• Raspè E, Mautino G, Duval C; et al. (2003). "Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha". J. Biol. Chem. 277 (51): 49275–81. doi:10.1074/jbc.M206215200. PMID 12377782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kallen J, Schlaeppi JM, Bitsch F; et al. (2004). "Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A.". J. Biol. Chem. 279 (14): 14033–8. doi:10.1074/jbc.M400302200. PMID 14722075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Migita H, Satozawa N, Lin JH; et al. (2004). "RORalpha1 and RORalpha4 suppress TNF-alpha-induced VCAM-1 and ICAM-1 expression in human endothelial cells". FEBS Lett. 557 (1–3): 269–74. PMID 14741380.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miki N, Ikuta M, Matsui T (2004). "Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor alpha4 gene by an interaction between hypoxia-inducible factor-1 and Sp1". J. Biol. Chem. 279 (15): 15025–31. doi:10.1074/jbc.M313186200. PMID 14742449.CS1 maint: Multiple names: authors list (link)
• Migita H, Morser J, Kawai K (2004). "Rev-erbalpha upregulates NF-kappaB-responsive genes in vascular smooth muscle cells". FEBS Lett. 561 (1–3): 69–74. doi:10.1016/S0014-5793(04)00118-8. PMID 15013753.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)