Pituitary-specific positive transcription factor 1

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
File:PBB Protein POU1F1 image.jpg PDB rendering based on 1au7.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1au7​
Identifiers
Symbols	POU1F1 ; GHF-1; PIT1; Pit-1; Pit-1 beta
External IDs	Template:OMIM5 Template:MGI HomoloGene: 259
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE POU1F1 207846 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM]

Further reading

• Parks JS, Brown MR (1999). "Transcription factors regulating pituitary development". Growth Horm. IGF Res. 9 Suppl B: 2–8, discussion 8-11. PMID 10549299.
• Rodriguez R, Andersen B (2003). "Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency". Minerva Endocrinol. 28 (2): 123–33. PMID 12717343.
• Quentien MH, Barlier A, Franc JL; et al. (2006). "Pituitary transcription factors: from congenital deficiencies to gene therapy". J. Neuroendocrinol. 18 (9): 633–42. doi:10.1111/j.1365-2826.2006.01461.x. PMID 16879162.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cattini PA, Yang X, Jin Y, Detillieux KA (2006). "Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression". Neuroendocrinology. 83 (3–4): 145–53. doi:10.1159/000095522. PMID 17047377.CS1 maint: Multiple names: authors list (link)
• Li X, Giachelli CM (2007). "Sodium-dependent phosphate cotransporters and vascular calcification". Curr. Opin. Nephrol. Hypertens. 16 (4): 325–8. doi:10.1097/MNH.0b013e3281c55ef1. PMID 17565274.
• Tatsumi K, Miyai K, Notomi T; et al. (1993). "Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene". Nat. Genet. 1 (1): 56–8. doi:10.1038/ng0492-56. PMID 1302000.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tatsumi K, Notomi T, Amino N, Miyai K (1992). "Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1". Biochim. Biophys. Acta. 1129 (2): 231–4. PMID 1370379.CS1 maint: Multiple names: authors list (link)
• Ohta K, Nobukuni Y, Mitsubuchi H; et al. (1993). "Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency". Biochem. Biophys. Res. Commun. 189 (2): 851–5. PMID 1472057.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohta K, Nobukuni Y, Mitsubuchi H; et al. (1993). "Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1". Gene. 122 (2): 387–8. PMID 1487156.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Radovick S, Nations M, Du Y; et al. (1992). "A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency". Science. 257 (5073): 1115–8. PMID 1509262.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pfäffle RW, DiMattia GE, Parks JS; et al. (1992). "Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia". Science. 257 (5073): 1118–21. PMID 1509263.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lew AM, Elsholtz HP (1991). "Cloning of the human cDNA for transcription factor Pit-1". Nucleic Acids Res. 19 (22): 6329. PMID 1956794.
• He X, Treacy MN, Simmons DM; et al. (1989). "Expression of a large family of POU-domain regulatory genes in mammalian brain development". Nature. 340 (6228): 35–41. doi:10.1038/340035a0. PMID 2739723.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bodner M, Castrillo JL, Theill LE; et al. (1988). "The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein". Cell. 55 (3): 505–18. PMID 2902927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herr W, Sturm RA, Clerc RG; et al. (1989). "The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products". Genes Dev. 2 (12A): 1513–6. PMID 3215510.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Zegher F, Pernasetti F, Vanhole C; et al. (1995). "The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency". J. Clin. Endocrinol. Metab. 80 (11): 3127–30. PMID 7593413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bamberger AM, Bamberger CM, Pu LP; et al. (1995). "Expression of pit-1 messenger ribonucleic acid and protein in the human placenta". J. Clin. Endocrinol. Metab. 80 (7): 2021–6. PMID 7608249.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Irie Y, Tatsumi K, Ogawa M; et al. (1995). "A novel E250X mutation of the PIT1 gene in a patient with combined pituitary hormone deficiency". Endocr. J. 42 (3): 351–4. PMID 7670563.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Delhase M, Vila V, Hooghe-Peters EL, Castrillo JL (1995). "A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 gene". Gene. 155 (2): 273–5. PMID 7721104.CS1 maint: Multiple names: authors list (link)
• Okamoto N, Wada Y, Ida S; et al. (1995). "Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype". Hum. Mol. Genet. 3 (9): 1565–8. PMID 7833912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• PIT1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Transcription+Factor+Pit-1 at the US National Library of Medicine Medical Subject Headings (MeSH)