POU3F2
| POU domain, class 3, transcription factor 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | POU3F2 ; BRN2; OCT7; OTF7; POUF3 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4095 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE POU3F2 207084 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
POU domain, class 3, transcription factor 2, also known as POU3F2, is a human gene.[1]
N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.[supplied by OMIM][1]
See also
References
Further reading
- Hara Y, Rovescalli AC, Kim Y, Nirenberg M (1992). "Structure and evolution of four POU domain genes expressed in mouse brain". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3280–4. PMID 1565620.
- Schreiber E, Harshman K, Kemler I; et al. (1990). "Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins". Nucleic Acids Res. 18 (18): 5495–503. PMID 2216722.
- He X, Treacy MN, Simmons DM; et al. (1989). "Expression of a large family of POU-domain regulatory genes in mammalian brain development". Nature. 340 (6228): 35–41. doi:10.1038/340035a0. PMID 2739723.
- Eisen T, Easty DJ, Bennett DC, Goding CR (1995). "The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression". Oncogene. 11 (10): 2157–64. PMID 7478537.
- Atanasoski S, Toldo SS, Malipiero U; et al. (1995). "Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16". Genomics. 26 (2): 272–80. PMID 7601453.
- Thomson JA, Murphy K, Baker E; et al. (1995). "The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells". Oncogene. 11 (4): 691–700. PMID 7651733.
- Schreiber E, Tobler A, Malipiero U; et al. (1993). "cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif". Nucleic Acids Res. 21 (2): 253–8. PMID 8441633.
- Atanasoski S, Schreiber E, Fontana A, Herr W (1997). "N-Oct 5 is generated by in vitro proteolysis of the neural POU-domain protein N-Oct 3". Oncogene. 14 (11): 1287–94. doi:10.1038/sj.onc.1200953. PMID 9178889.
- Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene". Mol. Endocrinol. 12 (2): 233–47. PMID 9482665.
- Kuhlbrodt K, Herbarth B, Sock E; et al. (1998). "Cooperative function of POU proteins and SOX proteins in glial cells". J. Biol. Chem. 273 (26): 16050–7. PMID 9632656.
- Waragai M, Lammers CH, Takeuchi S; et al. (1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival". Hum. Mol. Genet. 8 (6): 977–87. PMID 10332029.
- Smit DJ, Smith AG, Parsons PG; et al. (2000). "Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors". Eur. J. Biochem. 267 (21): 6413–22. PMID 11029584.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Jaegle M, Ghazvini M, Mandemakers W; et al. (2003). "The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development". Genes Dev. 17 (11): 1380–91. doi:10.1101/gad.258203. PMID 12782656.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Goodall J, Martinozzi S, Dexter TJ; et al. (2004). "Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin". Mol. Cell. Biol. 24 (7): 2915–22. PMID 15024079.
- Goodall J, Wellbrock C, Dexter TJ; et al. (2004). "The Brn-2 transcription factor links activated BRAF to melanoma proliferation". Mol. Cell. Biol. 24 (7): 2923–31. PMID 15024080.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Cobrinik D, Francis RO, Abramson DH, Lee TC (2007). "Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells". Mol. Cancer. 5: 72. doi:10.1186/1476-4598-5-72. PMID 17163992.
External links
- POU3F2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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