POU2F1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''POU domain, class 2, transcription factor 1''' is a [[protein]] that in humans is encoded by the ''POU2F1'' [[gene]].<ref name="pmid1887216">{{cite journal | vauthors = Roberts SB, Segil N, Heintz N | title = Differential phosphorylation of the transcription factor Oct1 during the cell cycle | journal = Science | volume = 253 | issue = 5023 | pages = 1022–6 | date = October 1991 | pmid = 1887216 | pmc = | doi = 10.1126/science.1887216 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5451| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_POU2F1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cqt.
| PDB = {{PDB2|1cqt}}, {{PDB2|1e3o}}, {{PDB2|1gt0}}, {{PDB2|1hf0}}, {{PDB2|1o4x}}, {{PDB2|1oct}}, {{PDB2|1pog}}, {{PDB2|1pou}}
| Name = POU domain, class 2, transcription factor 1
| HGNCid = 9212
| Symbol = POU2F1
| AltSymbols =; OCT1; OTF1
| OMIM = 164175
| ECnumber = 
| Homologene = 37658
| MGIid = 101898
| GeneAtlas_image1 = PBB_GE_POU2F1_206789_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5451
    | Hs_Ensembl = ENSG00000143190
    | Hs_RefseqProtein = NP_002688
    | Hs_RefseqmRNA = NM_002697
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 165456744
    | Hs_GenLoc_end = 165663206
    | Hs_Uniprot = P14859
    | Mm_EntrezGene = 18986
    | Mm_Ensembl = ENSMUSG00000026565
    | Mm_RefseqmRNA = NM_011137
    | Mm_RefseqProtein = NP_035267
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 167712151
    | Mm_GenLoc_end = 167839309
    | Mm_Uniprot = Q8C4C1
  }}
}}
'''POU domain, class 2, transcription factor 1''', also known as '''POU2F1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5451| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
POU2F1 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[EPRS]],<ref name = pmid9537509>{{cite journal | vauthors = Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T | title = Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase | journal = FEBS Lett. | volume = 424 | issue = 1-2 | pages = 27–32 | date = March 1998 | pmid = 9537509 | doi =  10.1016/s0014-5793(98)00131-8}}</ref>
| summary_text =  
* [[Glucocorticoid receptor]],<ref name = pmid10480874>{{cite journal | vauthors = Préfontaine GG, Walther R, Giffin W, Lemieux ME, Pope L, Haché RJ | title = Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter | journal = J. Biol. Chem. | volume = 274 | issue = 38 | pages = 26713–9 | date = September 1999 | pmid = 10480874 | doi =  10.1074/jbc.274.38.26713}}</ref><ref name = pmid10490647>{{cite journal | vauthors = Wang JM, Préfontaine GG, Lemieux ME, Pope L, Akimenko MA, Haché RJ | title = Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding | journal = Mol. Cell. Biol. | volume = 19 | issue = 10 | pages = 7106–22 | date = October 1999 | pmid = 10490647 | pmc = 84705 | doi =  10.1128/mcb.19.10.7106}}</ref><ref name = pmid9584182>{{cite journal | vauthors = Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E, Walker P, Haché RJ | title = Recruitment of octamer transcription factors to DNA by glucocorticoid receptor | journal = Mol. Cell. Biol. | volume = 18 | issue = 6 | pages = 3416–30 | date = June 1998 | pmid = 9584182 | pmc = 108923 | doi =  }}</ref>
}}
* [[Glyceraldehyde 3-phosphate dehydrogenase]],<ref name = pmid12887926/>
* [[Host cell factor C1]],<ref name = pmid9889203>{{cite journal | vauthors = La Boissière S, Hughes T, O'Hare P | title = HCF-dependent nuclear import of VP16 | journal = EMBO J. | volume = 18 | issue = 2 | pages = 480–9 | date = January 1999 | pmid = 9889203 | pmc = 1171141 | doi = 10.1093/emboj/18.2.480 }}</ref><ref name = pmid8454622>{{cite journal | vauthors = Kristie TM, Sharp PA | title = Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16) | journal = J. Biol. Chem. | volume = 268 | issue = 9 | pages = 6525–34 | date = March 1993 | pmid = 8454622 | doi =  }}</ref>
* [[Ku80]],<ref name = pmid11279128>{{cite journal | vauthors = Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ | title = The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 16848–56 | date = May 2001 | pmid = 11279128 | doi = 10.1074/jbc.M100768200 }}</ref><ref name = pmid12393188>{{cite journal | vauthors = Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M | title = Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication | journal = Biochim. Biophys. Acta | volume = 1578 | issue = 1-3 | pages = 59–72 | date = October 2002 | pmid = 12393188 | doi =  10.1016/s0167-4781(02)00497-9}}</ref>
* [[MNAT1]]<ref name = pmid9368058>{{cite journal | vauthors = Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG | title = The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors | journal = J. Biol. Chem. | volume = 272 | issue = 47 | pages = 29852–8 | date = November 1997 | pmid = 9368058 | doi =  10.1074/jbc.272.47.29852}}</ref>
* [[NPAT (gene)|NPAT]],<ref name = pmid12887926>{{cite journal | vauthors = McKnight S | title = Gene switching by metabolic enzymes--how did you get on the invitation list? | journal = Cell | volume = 114 | issue = 2 | pages = 150–2 | date = July 2003 | pmid = 12887915 | doi =  10.1016/s0092-8674(03)00563-4}}</ref>
* [[Nuclear receptor co-repressor 2]],<ref name = pmid11134019>{{cite journal | vauthors = Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J, Kumagai M, Yamashita K, Hashizume K | title = Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor | journal = J. Biol. Chem. | volume = 276 | issue = 13 | pages = 9720–5 | date = March 2001 | pmid = 11134019 | doi = 10.1074/jbc.M008531200 }}</ref>
* [[POU2AF1]],<ref name = pmid9418884/><ref name = pmid10541551>{{cite journal | vauthors = Chasman D, Cepek K, Sharp PA, Pabo CO | title = Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface | journal = Genes Dev. | volume = 13 | issue = 20 | pages = 2650–7 | date = October 1999 | pmid = 10541551 | pmc = 317104 | doi =  10.1101/gad.13.20.2650}}</ref><ref name = pmid11380252>{{cite journal | vauthors = Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B | title = Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator | journal = Biochemistry | volume = 40 | issue = 22 | pages = 6580–8 | date = June 2001 | pmid = 11380252 | doi = 10.1021/bi010095x}}</ref>
* [[RELA]],<ref name = pmid12019209>{{cite journal | vauthors = van Heel DA, Udalova IA, De Silva AP, McGovern DP, Kinouchi Y, Hull J, Lench NJ, Cardon LR, Carey AH, Jewell DP, Kwiatkowski D | title = Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors | journal = Hum. Mol. Genet. | volume = 11 | issue = 11 | pages = 1281–9 | date = May 2002 | pmid = 12019209 | doi =  10.1093/hmg/11.11.1281}}</ref>
* [[Retinoid X receptor alpha]],<ref name = pmid10480874/><ref name = pmid10383413>{{cite journal | vauthors = Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, ((Mori Ji)), Kumagai M, Hashizume K | title = Functional interaction between Oct-1 and retinoid X receptor | journal = J. Biol. Chem. | volume = 274 | issue = 27 | pages = 19103–8 | date = July 1999 | pmid = 10383413 | doi =  10.1074/jbc.274.27.19103}}</ref>
* [[SNAPC4]],<ref name = pmid9418884>{{cite journal | vauthors = Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N | title = The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1 | journal = Mol. Cell. Biol. | volume = 18 | issue = 1 | pages = 368–77 | date = January 1998 | pmid = 9418884 | pmc = 121507 | doi =  10.1128/mcb.18.1.368}}</ref><ref name = pmid11856838>{{cite journal | vauthors = Hovde S, Brooks A, Strong K, Geiger JH | title = Crystallization of the Oct-1/SNAP190 peptide/DNA complex | journal = Acta Crystallogr. D | volume = 58 | issue = Pt 3 | pages = 511–2 | date = March 2002 | pmid = 11856838 | doi =  10.1107/s0907444901021461}}</ref>
* [[Sp1 transcription factor]],<ref name = pmid8668525>{{cite journal | vauthors = Ström AC, Forsberg M, Lillhager P, Westin G | title = The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression | journal = Nucleic Acids Res. | volume = 24 | issue = 11 | pages = 1981–6 | date = June 1996 | pmid = 8668525 | pmc = 145891 | doi =  10.1093/nar/24.11.1981}}</ref><ref name = pmid10976766>{{cite journal | vauthors = Gunther M, Laithier M, Brison O | title = A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening | journal = Mol. Cell. Biochem. | volume = 210 | issue = 1-2 | pages = 131–42 | date = July 2000 | pmid = 10976766 | doi =  10.1023/A:1007177623283}}</ref>  and
* [[TATA binding protein]].<ref name = pmid8202368>{{cite journal | vauthors = Zwilling S, Annweiler A, Wirth T | title = The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP | journal = Nucleic Acids Res. | volume = 22 | issue = 9 | pages = 1655–62 | date = May 1994 | pmid = 8202368 | pmc = 308045 | doi =  10.1093/nar/22.9.1655}}</ref>
{{Div col end}}


==See also==
== See also ==
* [[Octamer transcription factor]]
* [[Octamer transcription factor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hsieh CL, Sturm R, Herr W, Francke U | title = The gene for the ubiquitous octamer-binding protein Oct–1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1 | journal = Genomics | volume = 6 | issue = 4 | pages = 666–72 | year = 1990 | pmid = 2341156 | doi = 10.1016/0888-7543(90)90502-L }}
| citations =
* {{cite journal | vauthors = Sturm RA, Das G, Herr W | title = The ubiquitous octamer-binding protein Oct–1 contains a POU domain with a homeo box subdomain | journal = Genes Dev. | volume = 2 | issue = 12A | pages = 1582–99 | year = 1989 | pmid = 2905684 | doi = 10.1101/gad.2.12a.1582 }}
*{{cite journal | author=Roberts SB, Segil N, Heintz N |title=Differential phosphorylation of the transcription factor Oct1 during the cell cycle. |journal=Science |volume=253 |issue= 5023 |pages= 1022-6 |year= 1991 |pmid= 1887216 |doi= }}
* {{cite journal | vauthors = Nakshatri H, Nakshatri P, Currie RA | title = Interaction of Oct–1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter | journal = J. Biol. Chem. | volume = 270 | issue = 33 | pages = 19613–23 | year = 1995 | pmid = 7642649 | doi = 10.1074/jbc.270.33.19613 }}
*{{cite journal  | author=Hsieh CL, Sturm R, Herr W, Francke U |title=The gene for the ubiquitous octamer-binding protein Oct-1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1. |journal=Genomics |volume=6 |issue= 4 |pages= 666-72 |year= 1990 |pmid= 2341156 |doi= }}
* {{cite journal | vauthors = Cox M, van Tilborg PJ, de Laat W, Boelens R, van Leeuwen HC, van der Vliet PC, Kaptein R | title = Solution structure of the Oct–1 POU homeodomain determined by NMR and restrained molecular dynamics | journal = J. Biomol. NMR | volume = 6 | issue = 1 | pages = 23–32 | year = 1995 | pmid = 7663141 | doi = 10.1007/BF00417488 }}
*{{cite journal | author=Sturm RA, Das G, Herr W |title=The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. |journal=Genes Dev. |volume=2 |issue= 12A |pages= 1582-99 |year= 1989 |pmid= 2905684 |doi= }}
* {{cite journal | vauthors = Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H | title = In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor | journal = J. Virol. | volume = 67 | issue = 10 | pages = 6224–33 | year = 1993 | pmid = 7690421 | pmc = 238044 | doi =  }}
*{{cite journal | author=Nakshatri H, Nakshatri P, Currie RA |title=Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19613-23 |year= 1995 |pmid= 7642649 |doi= }}
* {{cite journal | vauthors = Zwilling S, König H, Wirth T | title = High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors | journal = EMBO J. | volume = 14 | issue = 6 | pages = 1198–208 | year = 1995 | pmid = 7720710 | pmc = 398197 | doi =  }}
*{{cite journal | author=Cox M, van Tilborg PJ, de Laat W, ''et al.'' |title=Solution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics. |journal=J. Biomol. NMR |volume=6 |issue= 1 |pages= 23-32 |year= 1995 |pmid= 7663141 |doi=  }}
* {{cite journal | vauthors = Sturm RA, Eyre HJ, Baker E, Sutherland GR | title = The human OTF1 locus which overlaps the CD3Z gene is located at 1q22→q23 | journal = Cytogenet. Cell Genet. | volume = 68 | issue = 3–4 | pages = 231–2 | year = 1995 | pmid = 7842742 | doi = 10.1159/000133919 }}
*{{cite journal | author=Jeang KT, Chun R, Lin NH, ''et al.'' |title=In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. |journal=J. Virol. |volume=67 |issue= 10 |pages= 6224-33 |year= 1993 |pmid= 7690421 |doi=  }}
* {{cite journal | vauthors = Klemm JD, Rould MA, Aurora R, Herr W, Pabo CO | title = Crystal structure of the Oct–1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules | journal = Cell | volume = 77 | issue = 1 | pages = 21–32 | year = 1994 | pmid = 8156594 | doi = 10.1016/0092-8674(94)90231-3 }}
*{{cite journal | author=Zwilling S, König H, Wirth T |title=High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. |journal=EMBO J. |volume=14 |issue= 6 |pages= 1198-208 |year= 1995 |pmid= 7720710 |doi= }}
* {{cite journal | vauthors = Zwilling S, Annweiler A, Wirth T | title = The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP | journal = Nucleic Acids Res. | volume = 22 | issue = 9 | pages = 1655–62 | year = 1994 | pmid = 8202368 | pmc = 308045 | doi = 10.1093/nar/22.9.1655 }}
*{{cite journal | author=Sturm RA, Eyre HJ, Baker E, Sutherland GR |title=The human OTF1 locus which overlaps the CD3Z gene is located at 1q22-->q23. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 3-4 |pages= 231-2 |year= 1995 |pmid= 7842742 |doi= }}
* {{cite journal | vauthors = Kristie TM, Sharp PA | title = Purification of the cellular C1 factor required for the stable recognition of the Oct–1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16) | journal = J. Biol. Chem. | volume = 268 | issue = 9 | pages = 6525–34 | year = 1993 | pmid = 8454622 | doi =  }}
*{{cite journal | author=Klemm JD, Rould MA, Aurora R, ''et al.'' |title=Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. |journal=Cell |volume=77 |issue= 1 |pages= 21-32 |year= 1994 |pmid= 8156594 |doi= }}
* {{cite journal | vauthors = Assa-Munt N, Mortishire-Smith RJ, Aurora R, Herr W, Wright PE | title = The solution structure of the Oct–1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain | journal = Cell | volume = 73 | issue = 1 | pages = 193–205 | year = 1993 | pmid = 8462099 | doi = 10.1016/0092-8674(93)90171-L }}
*{{cite journal | author=Zwilling S, Annweiler A, Wirth T |title=The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP. |journal=Nucleic Acids Res. |volume=22 |issue= 9 |pages= 1655-62 |year= 1994 |pmid= 8202368 |doi=  }}
* {{cite journal | vauthors = Dekker N, Cox M, Boelens R, Verrijzer CP, van der Vliet PC, Kaptein R | title = Solution structure of the POU-specific DNA-binding domain of Oct–1 | journal = Nature | volume = 362 | issue = 6423 | pages = 852–5 | year = 1993 | pmid = 8479524 | doi = 10.1038/362852a0 }}
*{{cite journal | author=Kristie TM, Sharp PA |title=Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16). |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6525-34 |year= 1993 |pmid= 8454622 |doi= }}
* {{cite journal | vauthors = Ström AC, Forsberg M, Lillhager P, Westin G | title = The transcription factors Sp1 and Oct–1 interact physically to regulate human U2 snRNA gene expression | journal = Nucleic Acids Res. | volume = 24 | issue = 11 | pages = 1981–6 | year = 1996 | pmid = 8668525 | pmc = 145891 | doi = 10.1093/nar/24.11.1981 }}
*{{cite journal | author=Assa-Munt N, Mortishire-Smith RJ, Aurora R, ''et al.'' |title=The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain. |journal=Cell |volume=73 |issue= 1 |pages= 193-205 |year= 1993 |pmid= 8462099 |doi= }}
* {{cite journal | vauthors = Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG | title = The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors | journal = J. Biol. Chem. | volume = 272 | issue = 47 | pages = 29852–8 | year = 1997 | pmid = 9368058 | doi = 10.1074/jbc.272.47.29852 }}
*{{cite journal | author=Dekker N, Cox M, Boelens R, ''et al.'' |title=Solution structure of the POU-specific DNA-binding domain of Oct-1. |journal=Nature |volume=362 |issue= 6423 |pages= 852-5 |year= 1993 |pmid= 8479524 |doi= 10.1038/362852a0 }}
* {{cite journal | vauthors = Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N | title = The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct–1 | journal = Mol. Cell. Biol. | volume = 18 | issue = 1 | pages = 368–77 | year = 1998 | pmid = 9418884 | pmc = 121507 | doi =  10.1128/mcb.18.1.368}}
*{{cite journal | author=Ström AC, Forsberg M, Lillhager P, Westin G |title=The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression. |journal=Nucleic Acids Res. |volume=24 |issue= 11 |pages= 1981-6 |year= 1996 |pmid= 8668525 |doi= }}
* {{cite journal | vauthors = Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T | title = Interaction of Oct–1 and automodification domain of poly(ADP-ribose) synthetase | journal = FEBS Lett. | volume = 424 | issue = 1–2 | pages = 27–32 | year = 1998 | pmid = 9537509 | doi = 10.1016/S0014-5793(98)00131-8 }}
*{{cite journal | author=Inamoto S, Segil N, Pan ZQ, ''et al.'' |title=The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors. |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29852-8 |year= 1997 |pmid= 9368058 |doi=  }}
* {{cite journal | vauthors = Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E, Walker P, Haché RJ | title = Recruitment of Octamer Transcription Factors to DNA by Glucocorticoid Receptor | journal = Mol. Cell. Biol. | volume = 18 | issue = 6 | pages = 3416–30 | year = 1998 | pmid = 9584182 | pmc = 108923 | doi =  }}
*{{cite journal | author=Wong MW, Henry RW, Ma B, ''et al.'' |title=The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 368-77 |year= 1998 |pmid= 9418884 |doi= }}
* {{cite journal | vauthors = La Boissière S, Hughes T, O'Hare P | title = HCF-dependent nuclear import of VP16 | journal = EMBO J. | volume = 18 | issue = 2 | pages = 480–9 | year = 1999 | pmid = 9889203 | pmc = 1171141 | doi = 10.1093/emboj/18.2.480 }}
*{{cite journal | author=Nie J, Sakamoto S, Song D, ''et al.'' |title=Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase. |journal=FEBS Lett. |volume=424 |issue= 1-2 |pages= 27-32 |year= 1998 |pmid= 9537509 |doi=  }}
*{{cite journal | author=Préfontaine GG, Lemieux ME, Giffin W, ''et al.'' |title=Recruitment of octamer transcription factors to DNA by glucocorticoid receptor. |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3416-30 |year= 1998 |pmid= 9584182 |doi= }}
*{{cite journal  | author=La Boissière S, Hughes T, O'Hare P |title=HCF-dependent nuclear import of VP16. |journal=EMBO J. |volume=18 |issue= 2 |pages= 480-9 |year= 1999 |pmid= 9889203 |doi= 10.1093/emboj/18.2.480 }}
*{{cite journal  | author=Kakizawa T, Miyamoto T, Ichikawa K, ''et al.'' |title=Functional interaction between Oct-1 and retinoid X receptor. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19103-8 |year= 1999 |pmid= 10383413 |doi=  }}
}}
{{refend}}
{{refend}}


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* {{MeshName|POU2F1+protein,+human}}
* {{MeshName|POU2F1+protein,+human}}


{{PDB Gallery|geneid=5451}}
{{Transcription factors}}


{{protein-stub}}
[[Category:POU-domain proteins|g3]]
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 18:29, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.[1][2]

Interactions

POU2F1 has been shown to interact with:

See also

References

  1. ↑ Roberts SB, Segil N, Heintz N (October 1991). "Differential phosphorylation of the transcription factor Oct1 during the cell cycle". Science. 253 (5023): 1022–6. doi:10.1126/science.1887216. PMID 1887216.
  2. ↑ "Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1".
  3. ↑ Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T (March 1998). "Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase". FEBS Lett. 424 (1–2): 27–32. doi:10.1016/s0014-5793(98)00131-8. PMID 9537509.
  4. ↑ 4.0 4.1 Préfontaine GG, Walther R, Giffin W, Lemieux ME, Pope L, Haché RJ (September 1999). "Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter". J. Biol. Chem. 274 (38): 26713–9. doi:10.1074/jbc.274.38.26713. PMID 10480874.
  5. ↑ Wang JM, Préfontaine GG, Lemieux ME, Pope L, Akimenko MA, Haché RJ (October 1999). "Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding". Mol. Cell. Biol. 19 (10): 7106–22. doi:10.1128/mcb.19.10.7106. PMC 84705. PMID 10490647.
  6. ↑ Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E, Walker P, Haché RJ (June 1998). "Recruitment of octamer transcription factors to DNA by glucocorticoid receptor". Mol. Cell. Biol. 18 (6): 3416–30. PMC 108923. PMID 9584182.
  7. ↑ 7.0 7.1 McKnight S (July 2003). "Gene switching by metabolic enzymes--how did you get on the invitation list?". Cell. 114 (2): 150–2. doi:10.1016/s0092-8674(03)00563-4. PMID 12887915.
  8. ↑ La Boissière S, Hughes T, O'Hare P (January 1999). "HCF-dependent nuclear import of VP16". EMBO J. 18 (2): 480–9. doi:10.1093/emboj/18.2.480. PMC 1171141. PMID 9889203.
  9. ↑ Kristie TM, Sharp PA (March 1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. 268 (9): 6525–34. PMID 8454622.
  10. ↑ Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ (May 2001). "The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase". J. Biol. Chem. 276 (20): 16848–56. doi:10.1074/jbc.M100768200. PMID 11279128.
  11. ↑ Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (October 2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication". Biochim. Biophys. Acta. 1578 (1–3): 59–72. doi:10.1016/s0167-4781(02)00497-9. PMID 12393188.
  12. ↑ Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (November 1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. doi:10.1074/jbc.272.47.29852. PMID 9368058.
  13. ↑ Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J, Kumagai M, Yamashita K, Hashizume K (March 2001). "Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor". J. Biol. Chem. 276 (13): 9720–5. doi:10.1074/jbc.M008531200. PMID 11134019.
  14. ↑ 14.0 14.1 Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (January 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Mol. Cell. Biol. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.
  15. ↑ Chasman D, Cepek K, Sharp PA, Pabo CO (October 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551.
  16. ↑ Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (June 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252.
  17. ↑ van Heel DA, Udalova IA, De Silva AP, McGovern DP, Kinouchi Y, Hull J, Lench NJ, Cardon LR, Carey AH, Jewell DP, Kwiatkowski D (May 2002). "Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors". Hum. Mol. Genet. 11 (11): 1281–9. doi:10.1093/hmg/11.11.1281. PMID 12019209.
  18. ↑ Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, Mori Ji, Kumagai M, Hashizume K (July 1999). "Functional interaction between Oct-1 and retinoid X receptor". J. Biol. Chem. 274 (27): 19103–8. doi:10.1074/jbc.274.27.19103. PMID 10383413.
  19. ↑ Hovde S, Brooks A, Strong K, Geiger JH (March 2002). "Crystallization of the Oct-1/SNAP190 peptide/DNA complex". Acta Crystallogr. D. 58 (Pt 3): 511–2. doi:10.1107/s0907444901021461. PMID 11856838.
  20. ↑ Ström AC, Forsberg M, Lillhager P, Westin G (June 1996). "The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression". Nucleic Acids Res. 24 (11): 1981–6. doi:10.1093/nar/24.11.1981. PMC 145891. PMID 8668525.
  21. ↑ Gunther M, Laithier M, Brison O (July 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol. Cell. Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766.
  22. ↑ Zwilling S, Annweiler A, Wirth T (May 1994). "The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP". Nucleic Acids Res. 22 (9): 1655–62. doi:10.1093/nar/22.9.1655. PMC 308045. PMID 8202368.

Further reading

External links

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