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{{Infobox_gene}}
{{PBB_Controls
'''Nuclear factor 1 X-type''' is a [[protein]] that in humans is encoded by the ''NFIX'' [[gene]].<ref name="pmid8340106">{{cite journal | vauthors = Seisenberger C, Winnacker EL, Scherthan H | title = Localisation of the human nuclear factor I/X (NFI/X) gene to chromosome 19p13 and detection of five other related loci at 1p21-22, 1q42-43, 5q15, 11p13 and 20q13 by FISH | journal = Hum Genet | volume = 91 | issue = 6 | pages = 535–7 | date = Aug 1993 | pmid = 8340106 | pmc =  | doi = 10.1007/bf00205076 }}</ref><ref name="pmid7590749">{{cite journal | vauthors = Qian F, Kruse U, Lichter P, Sippel AE | title = Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH | journal = Genomics | volume = 28 | issue = 1 | pages = 66–73 | date = Dec 1995 | pmid = 7590749 | pmc =  | doi = 10.1006/geno.1995.1107 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4784| accessdate = }}</ref> NFI-X3, a [[Alternative splicing|splice variant]] of NFIX, regulates [[Glial fibrillary acidic protein]] and [[CHI3L1|YKL-40]] in [[astrocyte]]s.<ref name="pmid21953450">{{cite journal | vauthors = Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, Kordula T | title = A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40 | journal = J. Biol. Chem. | volume = 286 | issue = 46 | pages = 39893–903 | date = November 2011 | pmid = 21953450 | pmc = 3220556 | doi = 10.1074/jbc.M111.257451 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Nuclear factor I/X (CCAAT-binding transcription factor)
| HGNCid = 7788
| Symbol = NFIX
| AltSymbols =; NF1A
| OMIM = 164005
| ECnumber = 
| Homologene = 1872
| MGIid = 97311
| GeneAtlas_image1 = PBB_GE_NFIX_209807_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4784
    | Hs_Ensembl = ENSG00000008441
    | Hs_RefseqProtein = NP_002492
    | Hs_RefseqmRNA = NM_002501
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 12967584
    | Hs_GenLoc_end = 13070610
    | Hs_Uniprot = Q14938
    | Mm_EntrezGene = 18032
    | Mm_Ensembl = ENSMUSG00000001911
    | Mm_RefseqmRNA = NM_001081981
    | Mm_RefseqProtein = NP_001075450
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 87598719
    | Mm_GenLoc_end = 87663501
    | Mm_Uniprot = P70257
  }}
}}
'''Nuclear factor I/X (CCAAT-binding transcription factor)''', also known as '''NFIX''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4784| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
NFIX has been shown to [[Protein-protein interaction|interact]] with [[SKI protein]]<ref name="pmid9380514">{{cite journal | vauthors = Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E | title = DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI | journal = Nucleic Acids Res. | volume = 25 | issue = 19 | pages = 3895–903 | date = October 1997 | pmid = 9380514 | pmc = 146989 | doi = 10.1093/nar/25.19.3895 }}</ref> and it is also known to interact with [[AP-1 (transcription factor)|AP-1]].<ref name="pmid21953450"/> NFI-X3 has been shown to interact with [[STAT3]].<ref name="pmid21953450"/>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Apt D, Liu Y, Bernard HU | title = Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner. | journal = Nucleic Acids Res. | volume = 22 | issue = 19 | pages = 3825–33 | year = 1994 | pmid = 7937100 | pmc = 308376 | doi = 10.1093/nar/22.19.3825 }}
| citations =
* {{cite journal | vauthors = Sumner C, Shinohara T, Durham L, Traub R, Major EO, Amemiya K | title = Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes. | journal = J. Neurovirol. | volume = 2 | issue = 2 | pages = 87–100 | year = 1996 | pmid = 8799200 | doi = 10.3109/13550289609146542 }}
*{{cite journal | author=Qian F, Kruse U, Lichter P, Sippel AE |title=Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. |journal=Genomics |volume=28 |issue= 1 |pages= 66-73 |year= 1995 |pmid= 7590749 |doi= 10.1006/geno.1995.1107 }}
* {{cite journal | vauthors = Wendler WM, Kremmer E, Förster R, Winnacker EL | title = Identification of pirin, a novel highly conserved nuclear protein. | journal = J. Biol. Chem. | volume = 272 | issue = 13 | pages = 8482–9 | year = 1997 | pmid = 9079676 | doi = 10.1074/jbc.272.13.8482 }}
*{{cite journal  | author=Apt D, Liu Y, Bernard HU |title=Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner. |journal=Nucleic Acids Res. |volume=22 |issue= 19 |pages= 3825-33 |year= 1994 |pmid= 7937100 |doi= }}
* {{cite journal | vauthors = Liu Y, Bernard HU, Apt D | title = NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing. | journal = J. Biol. Chem. | volume = 272 | issue = 16 | pages = 10739–45 | year = 1997 | pmid = 9099724 | doi = 10.1074/jbc.272.16.10739 }}
*{{cite journal  | author=Seisenberger C, Winnacker EL, Scherthan H |title=Localisation of the human nuclear factor I/X (NFI/X) gene to chromosome 19p13 and detection of five other related loci at 1p21-22, 1q42-43, 5q15, 11p13 and 20q13 by FISH. |journal=Hum. Genet. |volume=91 |issue= 6 |pages= 535-7 |year= 1993 |pmid= 8340106 |doi=  }}
* {{cite journal | vauthors = Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E | title = DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI. | journal = Nucleic Acids Res. | volume = 25 | issue = 19 | pages = 3895–903 | year = 1997 | pmid = 9380514 | pmc = 146989 | doi = 10.1093/nar/25.19.3895 }}
*{{cite journal | author=Sumner C, Shinohara T, Durham L, ''et al.'' |title=Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes. |journal=J. Neurovirol. |volume=2 |issue= 2 |pages= 87-100 |year= 1996 |pmid= 8799200 |doi= }}
* {{cite journal | vauthors = Müller K, Mermod N | title = The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo. | journal = J. Biol. Chem. | volume = 275 | issue = 3 | pages = 1645–50 | year = 2000 | pmid = 10636857 | doi = 10.1074/jbc.275.3.1645 }}
*{{cite journal | author=Wendler WM, Kremmer E, Förster R, Winnacker EL |title=Identification of pirin, a novel highly conserved nuclear protein. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8482-9 |year= 1997 |pmid= 9079676 |doi= }}
* {{cite journal | vauthors = Nakazato M, Chung HK, Ulianich L, Grassadonia A, Suzuki K, Kohn LD | title = Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression. | journal = Mol. Cell. Biol. | volume = 20 | issue = 22 | pages = 8499–512 | year = 2000 | pmid = 11046146 | pmc = 102156 | doi = 10.1128/MCB.20.22.8499-8512.2000 }}
*{{cite journal | author=Liu Y, Bernard HU, Apt D |title=NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing. |journal=J. Biol. Chem. |volume=272 |issue= 16 |pages= 10739-45 |year= 1997 |pmid= 9099724 |doi= }}
* {{cite journal | vauthors = Imagawa M, Sakaue R, Tanabe A, Osada S, Nishihara T | title = Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A. | journal = FEBS Lett. | volume = 484 | issue = 2 | pages = 118–24 | year = 2000 | pmid = 11068044 | doi = 10.1016/S0014-5793(00)02119-0 }}
*{{cite journal | author=Tarapore P, Richmond C, Zheng G, ''et al.'' |title=DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI. |journal=Nucleic Acids Res. |volume=25 |issue= 19 |pages= 3895-903 |year= 1997 |pmid= 9380514 |doi= }}
* {{cite journal | vauthors = Norquay LD, Yang X, Sheppard P, Gregoire S, Dodd JG, Reith W, Cattini PA | title = RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin. | journal = Mol. Endocrinol. | volume = 17 | issue = 6 | pages = 1027–38 | year = 2003 | pmid = 12624117 | doi = 10.1210/me.2003-0025 }}
*{{cite journal | author=Müller K, Mermod N |title=The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo. |journal=J. Biol. Chem. |volume=275 |issue= 3 |pages= 1645-50 |year= 2000 |pmid= 10636857 |doi= }}
* {{cite journal | vauthors = Gopalan SM, Wilczynska KM, Konik BS, Bryan L, Kordula T | title = Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes. | journal = J. Biol. Chem. | volume = 281 | issue = 19 | pages = 13126–33 | year = 2006 | pmid = 16565071 | doi = 10.1074/jbc.M601194200 }}
*{{cite journal | author=Nakazato M, Chung HK, Ulianich L, ''et al.'' |title=Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression. |journal=Mol. Cell. Biol. |volume=20 |issue= 22 |pages= 8499-512 |year= 2000 |pmid= 11046146 |doi= }}
* {{cite journal | vauthors = Ravichandran V, Sabath BF, Jensen PN, Houff SA, Major EO | title = Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism. | journal = J. Virol. | volume = 80 | issue = 21 | pages = 10506–13 | year = 2006 | pmid = 16928756 | pmc = 1641797 | doi = 10.1128/JVI.01355-06 }}
*{{cite journal | author=Imagawa M, Sakaue R, Tanabe A, ''et al.'' |title=Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A. |journal=FEBS Lett. |volume=484 |issue= 2 |pages= 118-24 |year= 2000 |pmid= 11068044 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Norquay LD, Yang X, Sheppard P, ''et al.'' |title=RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin. |journal=Mol. Endocrinol. |volume=17 |issue= 6 |pages= 1027-38 |year= 2003 |pmid= 12624117 |doi= 10.1210/me.2003-0025 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal  | author=Gopalan SM, Wilczynska KM, Konik BS, ''et al.'' |title=Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes. |journal=J. Biol. Chem. |volume=281 |issue= 19 |pages= 13126-33 |year= 2006 |pmid= 16565071 |doi= 10.1074/jbc.M601194200 }}
*{{cite journal | author=Ravichandran V, Sabath BF, Jensen PN, ''et al.'' |title=Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism. |journal=J. Virol. |volume=80 |issue= 21 |pages= 10506-13 |year= 2006 |pmid= 16928756 |doi= 10.1128/JVI.01355-06 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|NFIX+protein,+human}}
* {{MeshName|NFIX+protein,+human}}
{{NLM content}}
{{Transcription factors|g1}}
[[Category:Transcription factors]]




{{gene-19-stub}}
{{gene-19-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 12:52, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene.[1][2][3] NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.[4]

Interactions

NFIX has been shown to interact with SKI protein[5] and it is also known to interact with AP-1.[4] NFI-X3 has been shown to interact with STAT3.[4]

References

  1. ↑ Seisenberger C, Winnacker EL, Scherthan H (Aug 1993). "Localisation of the human nuclear factor I/X (NFI/X) gene to chromosome 19p13 and detection of five other related loci at 1p21-22, 1q42-43, 5q15, 11p13 and 20q13 by FISH". Hum Genet. 91 (6): 535–7. doi:10.1007/bf00205076. PMID 8340106.
  2. ↑ Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
  3. ↑ "Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)".
  4. ↑ 4.0 4.1 4.2 Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, Kordula T (November 2011). "A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40". J. Biol. Chem. 286 (46): 39893–903. doi:10.1074/jbc.M111.257451. PMC 3220556. PMID 21953450.
  5. ↑ Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E (October 1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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