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{{about|the human gene|the computer game|Myst IV}}
{{PBB_Controls
 
| update_page = yes
{{Infobox_gene}}
| require_manual_inspection = no
'''Histone acetyltransferase MYST4''' is an [[enzyme]] that in humans is encoded by the ''MYST4'' [[gene]].<ref name="pmid9205841">{{cite journal |vauthors=Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 4 | issue = 2 | pages = 141–50 | date = Sep 1997 | pmid = 9205841 | pmc =  | doi = 10.1093/dnares/4.2.141 }}</ref><ref name="pmid10497217">{{cite journal |vauthors=Champagne N, Bertos NR, Pelletier N, Wang AH, Vezmar M, Yang Y, Heng HH, Yang XJ | title = Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein | journal = J Biol Chem | volume = 274 | issue = 40 | pages = 28528–36 | date = Nov 1999 | pmid = 10497217 | pmc = | doi = 10.1074/jbc.274.40.28528 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYST4 MYST histone acetyltransferase (monocytic leukemia) 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23522| accessdate = }}</ref>
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{GNF_Protein_box
MYST4 has been shown to [[Protein-protein interaction|interact]] with [[RUNX2]].<ref name=pmid11965546>{{cite journal |vauthors=Pelletier N, Champagne N, Stifani S, Yang XJ | title = MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2 | journal = Oncogene | volume = 21 | issue = 17 | pages = 2729–40 | date = Apr 2002 | pmid = 11965546 | doi = 10.1038/sj.onc.1205367 }}</ref>
| image = 
| image_source =
| PDB =  
| Name = MYST histone acetyltransferase (monocytic leukemia) 4
| HGNCid = 17582
| Symbol = MYST4
| AltSymbols =; DKFZp313G1618; FLJ90335; KIAA0383; MORF; MOZ2; qkf; querkopf
| OMIM = 605880
| ECnumber = 
| Homologene = 49310
| MGIid = 1858746
| GeneAtlas_image1 = PBB_GE_MYST4_212462_at_tn.png
| GeneAtlas_image2 = PBB_GE_MYST4_211874_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MYST4_212452_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004406 |text = H3/H4 histone acetyltransferase activity}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016407 |text = acetyltransferase activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}} {{GNF_GO|id=GO:0016573 |text = histone acetylation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23522
    | Hs_Ensembl = ENSG00000156650
    | Hs_RefseqProtein = NP_036462
    | Hs_RefseqmRNA = NM_012330
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 76255346
    | Hs_GenLoc_end = 76462386
    | Hs_Uniprot = Q8WYB5
    | Mm_EntrezGene = 54169
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_017479
    | Mm_RefseqProtein = NP_059507
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
{{about|the human gene|the computer game|Myst IV}}
'''MYST histone acetyltransferase (monocytic leukemia) 4''', also known as '''MYST4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYST4 MYST histone acetyltransferase (monocytic leukemia) 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23522| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Young Simpson syndrome==
{{PBB_Summary
It has been demonstrated  that ''de novo'' mutations in the gene '''MYST4''' causes  the [[Young Simpson syndrome]] and [[genitopatellar syndrome]].<ref name=pmid.22265014>{{cite journal |vauthors=Campeau PM, Kim JC, Lu JT, Schwartzentruber JA, Abdul-Rahman OA, Schlaubitz S, Murdock DM, Jiang MM, Lammer EJ, Enns GM, Rhead WJ, Rowland J, Robertson SP, Cormier-Daire V, Bainbridge MN, Yang XJ, Gingras MC, Gibbs RA, Rosenblatt DS, Majewski J, Lee BH | title = Mutations in KAT6B, Encoding a Histone Acetyltransferase, Cause Genitopatellar Syndrome. | journal = American Journal of Human Genetics | volume = 90 | issue = 2 | pages = 282–9 | date = Jan 18, 2012 | pmid = 22265014 | pmc = 3276659 | doi = 10.1016/j.ajhg.2011.11.023 }}</ref><ref>{{cite journal |vauthors=Clayton-Smith J, O'Sullivan J, Daly S, Bhaskar S, Day R, Anderson B, Voss AK, Thomas T, Biesecker LG, Smith P, Fryer A, Chandler KE, Kerr B, Tassabehji M, Lynch SA, Krajewska-Walasek M, McKee S, Smith J, Sweeney E, Mansour S, Mohammed S, Donnai D, Black G | title = Whole-Exome-Sequencing Identifies Mutations in Histone Acetyltransferase Gene KAT6B in Individuals with the Say-Barber-Biesecker Variant of Ohdo Syndrome | language = | journal = Am. J. Hum. Genet. | volume = 89 | issue = 5 | pages = 675–81 | date = Nov 2011 | pmid = 22077973 | doi = 10.1016/j.ajhg.2011.10.008 | pmc=3213399}}</ref><ref>{{cite journal |vauthors=Campeau PM, Kim JC, Lu JT, Schwartzentruber JA, Abdul-Rahman OA, Schlaubitz S, Murdock DM, Jiang MM, Lammer EJ, Enns GM, Rhead WJ, Rowland J, Robertson SP, Cormier-Daire V, Bainbridge MN, Yang XJ, Gingras MC, Gibbs RA, Rosenblatt DS, Majewski J, Lee BH | title = Mutations in KAT6B, Encoding a Histone Acetyltransferase, Cause Genitopatellar Syndrome | language = | journal = [[American Journal of Human Genetics]] | volume = 90 | issue = 2 | pages = 282–9 | date = Jan 2012 | pmid = 22265014 | pmc = 3276659 | doi = 10.1016/j.ajhg.2011.11.023 }}</ref><ref name=pmid.22715153>{{cite journal |vauthors=Campeau PM, Lu JT, Dawson BC, Fokkema IF, Robertson SP, Gibbs RA, Lee BH | title = The KAT6B-related disorders Genitopatellar syndrome and Ohdo/SBBYS syndrome have distinct clinical features reflecting distinct molecular mechanisms. | journal = Human Mutation | volume = 33 | issue = 11 | pages = 1520–5 | date = Jun 19, 2012 | pmid = 22715153 | doi = 10.1002/humu.22141 }}</ref>
| section_title =  
| summary_text =  
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Pena AN, Pereira-Smith OM | title = The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging | journal = Ann. N. Y. Acad. Sci. | volume = 1100 | issue =  | pages = 299–305 | year = 2007 | pmid = 17460191 | doi = 10.1196/annals.1395.031 }}
| citations =
*{{cite journal |vauthors=Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2003 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
*{{cite journal | author=Pena AN, Pereira-Smith OM |title=The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging. |journal=Ann. N. Y. Acad. Sci. |volume=1100 |issue=  |pages= 299-305 |year= 2007 |pmid= 17460191 |doi= 10.1196/annals.1395.031 }}
*{{cite journal |vauthors=Topper M, Luo Y, Zhadina M, Mohammed K, Smith L, Muesing MA | title = Posttranslational Acetylation of the Human Immunodeficiency Virus Type 1 Integrase Carboxyl-Terminal Domain Is Dispensable for Viral Replication | journal = J. Virol. | volume = 81 | issue = 6 | pages = 3012–7 | year = 2007 | pmid = 17182677 | pmc = 1865993 | doi = 10.1128/JVI.02257-06 }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
*{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Topper M, Luo Y, Zhadina M, ''et al.'' |title=Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication. |journal=J. Virol. |volume=81 |issue= 6 |pages= 3012-7 |year= 2007 |pmid= 17182677 |doi= 10.1128/JVI.02257-06 }}
*{{cite journal |vauthors=Cereseto A, Manganaro L, Gutierrez MI, Terreni M, Fittipaldi A, Lusic M, Marcello A, Giacca M | title = Acetylation of HIV-1 integrase by p300 regulates viral integration | journal = EMBO J. | volume = 24 | issue = 17 | pages = 3070–81 | year = 2005 | pmid = 16096645 | pmc = 1201351 | doi = 10.1038/sj.emboj.7600770 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Cereseto A, Manganaro L, Gutierrez MI, ''et al.'' |title=Acetylation of HIV-1 integrase by p300 regulates viral integration. |journal=EMBO J. |volume=24 |issue= 17 |pages= 3070-81 |year= 2005 |pmid= 16096645 |doi= 10.1038/sj.emboj.7600770 }}
*{{cite journal |vauthors=Liu C, Lu J, Tan J, Li L, Huang B | title = Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/EBP, NF-AT and AP-1 | journal = Cytokine | volume = 27 | issue = 4–5 | pages = 93–100 | year = 2005 | pmid = 15271374 | doi = 10.1016/j.cyto.2004.02.003 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal |vauthors=Pelletier N, Champagne N, Stifani S, Yang XJ | title = MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2 | journal = Oncogene | volume = 21 | issue = 17 | pages = 2729–40 | year = 2002 | pmid = 11965546 | doi = 10.1038/sj.onc.1205367 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal |vauthors=Panagopoulos I, Fioretos T, Isaksson M, Samuelsson U, Billström R, Strömbeck B, Mitelman F, Johansson B | title = Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13) | journal = Hum. Mol. Genet. | volume = 10 | issue = 4 | pages = 395–404 | year = 2001 | pmid = 11157802 | doi = 10.1093/hmg/10.4.395 }}
*{{cite journal | author=Liu C, Lu J, Tan J, ''et al.'' |title=Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/EBP, NF-AT and AP-1. |journal=Cytokine |volume=27 |issue= 4-5 |pages= 93-100 |year= 2005 |pmid= 15271374 |doi= 10.1016/j.cyto.2004.02.003 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Pelletier N, Champagne N, Stifani S, Yang XJ |title=MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. |journal=Oncogene |volume=21 |issue= 17 |pages= 2729-40 |year= 2002 |pmid= 11965546 |doi= 10.1038/sj.onc.1205367 }}
*{{cite journal | author=Panagopoulos I, Fioretos T, Isaksson M, ''et al.'' |title=Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13). |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 395-404 |year= 2001 |pmid= 11157802 |doi= }}
*{{cite journal  | author=Champagne N, Bertos NR, Pelletier N, ''et al.'' |title=Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. |journal=J. Biol. Chem. |volume=274 |issue= 40 |pages= 28528-36 |year= 1999 |pmid= 10497217 |doi=  }}
*{{cite journal  | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi=  }}
}}
{{refend}}
{{refend}}


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* {{MeshName|MYST4+protein,+human}}
* {{MeshName|MYST4+protein,+human}}


{{protein-stub}}
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{{Transcription factors}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
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{{gene-10-stub}}

Revision as of 07:16, 4 September 2017

This article is about the human gene. For the computer game, see Myst IV.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Histone acetyltransferase MYST4 is an enzyme that in humans is encoded by the MYST4 gene.[1][2][3]

Interactions

MYST4 has been shown to interact with RUNX2.[4]

Young Simpson syndrome

It has been demonstrated that de novo mutations in the gene MYST4 causes the Young Simpson syndrome and genitopatellar syndrome.[5][6][7][8]

References

  1. ↑ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  2. ↑ Champagne N, Bertos NR, Pelletier N, Wang AH, Vezmar M, Yang Y, Heng HH, Yang XJ (Nov 1999). "Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein". J Biol Chem. 274 (40): 28528–36. doi:10.1074/jbc.274.40.28528. PMID 10497217.
  3. ↑ "Entrez Gene: MYST4 MYST histone acetyltransferase (monocytic leukemia) 4".
  4. ↑ Pelletier N, Champagne N, Stifani S, Yang XJ (Apr 2002). "MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2". Oncogene. 21 (17): 2729–40. doi:10.1038/sj.onc.1205367. PMID 11965546.
  5. ↑ Campeau PM, Kim JC, Lu JT, Schwartzentruber JA, Abdul-Rahman OA, Schlaubitz S, Murdock DM, Jiang MM, Lammer EJ, Enns GM, Rhead WJ, Rowland J, Robertson SP, Cormier-Daire V, Bainbridge MN, Yang XJ, Gingras MC, Gibbs RA, Rosenblatt DS, Majewski J, Lee BH (Jan 18, 2012). "Mutations in KAT6B, Encoding a Histone Acetyltransferase, Cause Genitopatellar Syndrome". American Journal of Human Genetics. 90 (2): 282–9. doi:10.1016/j.ajhg.2011.11.023. PMC 3276659. PMID 22265014.
  6. ↑ Clayton-Smith J, O'Sullivan J, Daly S, Bhaskar S, Day R, Anderson B, Voss AK, Thomas T, Biesecker LG, Smith P, Fryer A, Chandler KE, Kerr B, Tassabehji M, Lynch SA, Krajewska-Walasek M, McKee S, Smith J, Sweeney E, Mansour S, Mohammed S, Donnai D, Black G (Nov 2011). "Whole-Exome-Sequencing Identifies Mutations in Histone Acetyltransferase Gene KAT6B in Individuals with the Say-Barber-Biesecker Variant of Ohdo Syndrome". Am. J. Hum. Genet. 89 (5): 675–81. doi:10.1016/j.ajhg.2011.10.008. PMC 3213399. PMID 22077973.
  7. ↑ Campeau PM, Kim JC, Lu JT, Schwartzentruber JA, Abdul-Rahman OA, Schlaubitz S, Murdock DM, Jiang MM, Lammer EJ, Enns GM, Rhead WJ, Rowland J, Robertson SP, Cormier-Daire V, Bainbridge MN, Yang XJ, Gingras MC, Gibbs RA, Rosenblatt DS, Majewski J, Lee BH (Jan 2012). "Mutations in KAT6B, Encoding a Histone Acetyltransferase, Cause Genitopatellar Syndrome". American Journal of Human Genetics. 90 (2): 282–9. doi:10.1016/j.ajhg.2011.11.023. PMC 3276659. PMID 22265014.
  8. ↑ Campeau PM, Lu JT, Dawson BC, Fokkema IF, Robertson SP, Gibbs RA, Lee BH (Jun 19, 2012). "The KAT6B-related disorders Genitopatellar syndrome and Ohdo/SBBYS syndrome have distinct clinical features reflecting distinct molecular mechanisms". Human Mutation. 33 (11): 1520–5. doi:10.1002/humu.22141. PMID 22715153.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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