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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Meis1''' is a [[protein]] that in humans is encoded by the '''MEIS1''' [[gene]].<ref name="pmid7565694">{{cite journal | vauthors = Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM | title = Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice | journal = Molecular and Cellular Biology | volume = 15 | issue = 10 | pages = 5434–43 | date = Oct 1995 | pmid = 7565694 | pmc = 230793 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MEIS1 Meis homeobox 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4211| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Meis homeobox 1
| HGNCid = 7000
| Symbol = MEIS1
| AltSymbols =; MGC43380
| OMIM = 601739
| ECnumber = 
| Homologene = 86803
| MGIid = 104717
| GeneAtlas_image1 = PBB_GE_MEIS1_204069_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4211
    | Hs_Ensembl = ENSG00000143995
    | Hs_RefseqProtein = NP_002389
    | Hs_RefseqmRNA = NM_002398
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 66516036
    | Hs_GenLoc_end = 66653394
    | Hs_Uniprot = O00470
    | Mm_EntrezGene = 17268
    | Mm_Ensembl = ENSMUSG00000020160
    | Mm_RefseqmRNA = NM_010789
    | Mm_RefseqProtein = NP_034919
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 18781632
    | Mm_GenLoc_end = 18918717
    | Mm_Uniprot = Q3UJ00
  }}
}}
'''Meis homeobox 1''', also known as '''MEIS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MEIS1 Meis homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4211| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.<ref name="entrez">{{cite web | title = Entrez Gene: MEIS1 Meis homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4211| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MEIS1 has been shown to [[Protein-protein interaction|interact]] with [[PBX1]]<ref name=pmid10082572>{{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 }}</ref><ref name=pmid10523646>{{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–88 | date = Nov 1999 | pmid = 10523646 | pmc = 84774 }}</ref><ref name=pmid10373562>{{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–42 | date = Jul 1999 | pmid = 10373562 | pmc = 84356 }}</ref> and [[HOXA9]].<ref name=pmid10082572/><ref name=pmid9343407>{{cite journal | vauthors = Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C | title = AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins | journal = Molecular and Cellular Biology | volume = 17 | issue = 11 | pages = 6448–58 | date = Nov 1997 | pmid = 9343407 | pmc = 232497 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Allen TD, Zhu YX, Hawley TS, Hawley RG | title = TALE homeoproteins as HOX11-interacting partners in T-cell leukemia | journal = Leukemia & Lymphoma | volume = 39 | issue = 3-4 | pages = 241–56 | date = Oct 2000 | pmid = 11342305 | doi = 10.3109/10428190009065824 }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Allen TD, Zhu YX, Hawley TS, Hawley RG |title=TALE homeoproteins as HOX11-interacting partners in T-cell leukemia. |journal=Leuk. Lymphoma |volume=39 |issue= 3-4 |pages= 241-56 |year= 2001 |pmid= 11342305 |doi= }}
* {{cite journal | vauthors = Steelman S, Moskow JJ, Muzynski K, North C, Druck T, Montgomery JC, Huebner K, Daar IO, Buchberg AM | title = Identification of a conserved family of Meis1-related homeobox genes | journal = Genome Research | volume = 7 | issue = 2 | pages = 142–56 | date = Feb 1997 | pmid = 9049632 | doi = 10.1101/gr.7.2.142 }}
*{{cite journal  | author=Moskow JJ, Bullrich F, Huebner K, ''et al.'' |title=Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. |journal=Mol. Cell. Biol. |volume=15 |issue= 10 |pages= 5434-43 |year= 1995 |pmid= 7565694 |doi=  }}
* {{cite journal | vauthors = Smith JE, Bollekens JA, Inghirami G, Takeshita K | title = Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene | journal = Genomics | volume = 43 | issue = 1 | pages = 99–103 | date = Jul 1997 | pmid = 9226379 | doi = 10.1006/geno.1997.4766 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C | title = AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins | journal = Molecular and Cellular Biology | volume = 17 | issue = 11 | pages = 6448–58 | date = Nov 1997 | pmid = 9343407 | pmc = 232497 | doi =  }}
*{{cite journal | author=Steelman S, Moskow JJ, Muzynski K, ''et al.'' |title=Identification of a conserved family of Meis1-related homeobox genes. |journal=Genome Res. |volume=7 |issue= 2 |pages= 142-56 |year= 1997 |pmid= 9049632 |doi= }}
* {{cite journal | vauthors = Knoepfler PS, Calvo KR, Chen H, Antonarakis SE, Kamps MP | title = Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 26 | pages = 14553–8 | date = Dec 1997 | pmid = 9405651 | pmc = 25052 | doi = 10.1073/pnas.94.26.14553 }}
*{{cite journal | author=Smith JE, Bollekens JA, Inghirami G, Takeshita K |title=Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene. |journal=Genomics |volume=43 |issue= 1 |pages= 99-103 |year= 1997 |pmid= 9226379 |doi= 10.1006/geno.1997.4766 }}
* {{cite journal | vauthors = | title = Toward a complete human genome sequence | journal = Genome Research | volume = 8 | issue = 11 | pages = 1097–108 | date = Nov 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
*{{cite journal | author=Shen WF, Montgomery JC, Rozenfeld S, ''et al.'' |title=AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6448-58 |year= 1997 |pmid= 9343407 |doi=  }}
* {{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 | doi =  }}
*{{cite journal | author=Knoepfler PS, Calvo KR, Chen H, ''et al.'' |title=Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14553-8 |year= 1998 |pmid= 9405651 |doi= }}
* {{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–42 | date = Jul 1999 | pmid = 10373562 | pmc = 84356 | doi =  }}
*{{cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi= }}
* {{cite journal | vauthors = Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP | title = A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1 | journal = Nucleic Acids Research | volume = 27 | issue = 18 | pages = 3752–61 | date = Sep 1999 | pmid = 10471746 | pmc = 148632 | doi = 10.1093/nar/27.18.3752 }}
*{{cite journal | author=Shen WF, Rozenfeld S, Kwong A, ''et al.'' |title=HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 3051-61 |year= 1999 |pmid= 10082572 |doi=  }}
* {{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–88 | date = Nov 1999 | pmid = 10523646 | pmc = 84774 | doi =  }}
*{{cite journal | author=Jacobs Y, Schnabel CA, Cleary ML |title=Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5134-42 |year= 1999 |pmid= 10373562 |doi=  }}
* {{cite journal | vauthors = Spieker N, van Sluis P, Beitsma M, Boon K, van Schaik BD, van Kampen AH, Caron H, Versteeg R | title = The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32 | journal = Genomics | volume = 71 | issue = 2 | pages = 214–21 | date = Jan 2001 | pmid = 11161815 | doi = 10.1006/geno.2000.6408 }}
*{{cite journal | author=Knoepfler PS, Bergstrom DA, Uetsuki T, ''et al.'' |title=A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. |journal=Nucleic Acids Res. |volume=27 |issue= 18 |pages= 3752-61 |year= 1999 |pmid= 10471746 |doi= }}
* {{cite journal | vauthors = Wang Y, Yin L, Hillgartner FB | title = The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid hormone regulation of the malic enzyme gene in hepatocytes | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 23838–48 | date = Jun 2001 | pmid = 11331288 | doi = 10.1074/jbc.M102166200 }}
*{{cite journal | author=Shanmugam K, Green NC, Rambaldi I, ''et al.'' |title=PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7577-88 |year= 1999 |pmid= 10523646 |doi=  }}
* {{cite journal | vauthors = Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T | title = Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene | journal = Blood | volume = 101 | issue = 12 | pages = 4748–56 | date = Jun 2003 | pmid = 12609849 | doi = 10.1182/blood-2002-02-0380 }}
*{{cite journal | author=Spieker N, van Sluis P, Beitsma M, ''et al.'' |title=The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32. |journal=Genomics |volume=71 |issue= 2 |pages= 214-21 |year= 2001 |pmid= 11161815 |doi= 10.1006/geno.2000.6408 }}
* {{cite journal | vauthors = Zeisig BB, Milne T, García-Cuéllar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK | title = Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization | journal = Molecular and Cellular Biology | volume = 24 | issue = 2 | pages = 617–28 | date = Jan 2004 | pmid = 14701735 | pmc = 343796 | doi = 10.1128/MCB.24.2.617-628.2004 }}
*{{cite journal | author=Wang Y, Yin L, Hillgartner FB |title=The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid hormone regulation of the malic enzyme gene in hepatocytes. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23838-48 |year= 2001 |pmid= 11331288 |doi= 10.1074/jbc.M102166200 }}
* {{cite journal | vauthors = Pineault N, Abramovich C, Ohta H, Humphries RK | title = Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1 | journal = Molecular and Cellular Biology | volume = 24 | issue = 5 | pages = 1907–17 | date = Mar 2004 | pmid = 14966272 | pmc = 350554 | doi = 10.1128/MCB.24.5.1907-1917.2004 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Okada Y, Nagai R, Sato T, ''et al.'' |title=Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. |journal=Blood |volume=101 |issue= 12 |pages= 4748-56 |year= 2004 |pmid= 12609849 |doi= 10.1182/blood-2002-02-0380 }}
*{{cite journal | author=Zeisig BB, Milne T, García-Cuéllar MP, ''et al.'' |title=Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 617-28 |year= 2004 |pmid= 14701735 |doi= }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Pineault N, Abramovich C, Ohta H, Humphries RK |title=Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1907-17 |year= 2004 |pmid= 14966272 |doi= }}
}}
{{refend}}
{{refend}}


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* {{MeshName|MEIS1+protein,+human}}
* {{MeshName|MEIS1+protein,+human}}


{{NLM content}}
{{Transcription factors|g3}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Latest revision as of 01:54, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.[1][2]

Function

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.[2]

Interactions

MEIS1 has been shown to interact with PBX1[3][4][5] and HOXA9.[3][6]

References

  1. ↑ Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology. 15 (10): 5434–43. PMC 230793. PMID 7565694.
  2. ↑ 2.0 2.1 "Entrez Gene: MEIS1 Meis homeobox 1".
  3. ↑ 3.0 3.1 Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. PMC 84099. PMID 10082572.
  4. ↑ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. PMC 84774. PMID 10523646.
  5. ↑ Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–42. PMC 84356. PMID 10373562.
  6. ↑ Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–58. PMC 232497. PMID 9343407.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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