MEF2D: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Myocyte-specific enhancer factor 2D''' is a [[protein]] that in humans is encoded by the ''MEF2D'' [[gene]].<ref name="pmid8269842">{{cite journal | vauthors = Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B | title = A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage | journal = Development | volume = 118 | issue = 4 | pages = 1095–106 | date = Aug 1993 | pmid = 8269842 | pmc = | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4209| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_MEF2D_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1c7u.
| PDB = {{PDB2|1c7u}}, {{PDB2|1egw}}
| Name = MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)
| HGNCid = 6997
| Symbol = MEF2D
| AltSymbols =; DKFZp686I1536
| OMIM = 600663
| ECnumber = 
| Homologene = 4327
| MGIid = 99533
| GeneAtlas_image1 = PBB_GE_MEF2D_203003_at_tn.png
| GeneAtlas_image2 = PBB_GE_MEF2D_203004_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007517 |text = muscle development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4209
    | Hs_Ensembl = ENSG00000116604
    | Hs_RefseqProtein = NP_005911
    | Hs_RefseqmRNA = NM_005920
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 154700143
    | Hs_GenLoc_end = 154737244
    | Hs_Uniprot = Q14814
    | Mm_EntrezGene = 17261
    | Mm_Ensembl = ENSMUSG00000001419
    | Mm_RefseqmRNA = XM_987375
    | Mm_RefseqProtein = XP_992469
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 88228354
    | Mm_GenLoc_end = 88254650
    | Mm_Uniprot = Q3URR2
  }}
}}
'''MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)''', also known as '''MEF2D''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4209| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
MEF2D has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[CABIN1]],<ref name = pmid10933397/><ref name = pmid10531067>{{cite journal | vauthors = Youn HD, Sun L, Prywes R, Liu JO | title = Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 | journal = Science | volume = 286 | issue = 5440 | pages = 790–3 | date = Oct 1999 | pmid = 10531067 | doi =  10.1126/science.286.5440.790}}</ref>
| summary_text =  
* [[EP300]],<ref name = pmid10825153>{{cite journal | vauthors = Youn HD, Grozinger CM, Liu JO | title = Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 29 | pages = 22563–7 | date = Jul 2000 | pmid = 10825153 | doi = 10.1074/jbc.C000304200 }}</ref><ref name = pmid10933397>{{cite journal | vauthors = Youn HD, Liu JO | title = Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 | journal = Immunity | volume = 13 | issue = 1 | pages = 85–94 | date = Jul 2000 | pmid = 10933397 | doi =  10.1016/s1074-7613(00)00010-8}}</ref>
}}
* [[MAPK7]],<ref name = pmid9753748>{{cite journal | vauthors = Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA | title = Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1 | journal = Nucleic Acids Research | volume = 26 | issue = 20 | pages = 4771–7 | date = Oct 1998 | pmid = 9753748 | pmc = 147902 | doi = 10.1093/nar/26.20.4771}}</ref>
* [[Myocyte-specific enhancer factor 2A]],<ref name = pmid8798771>{{cite journal | vauthors = Ornatsky OI, McDermott JC | title = MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells | journal = The Journal of Biological Chemistry | volume = 271 | issue = 40 | pages = 24927–33 | date = Oct 1996 | pmid = 8798771 | doi =  10.1074/jbc.271.40.24927}}</ref>  
* [[NFATC2]]<ref name = pmid10944115>{{cite journal | vauthors = Youn HD, Chatila TA, Liu JO | title = Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis | journal = The EMBO Journal | volume = 19 | issue = 16 | pages = 4323–31 | date = Aug 2000 | pmid = 10944115 | pmc = 302027 | doi = 10.1093/emboj/19.16.4323 }}</ref>
* [[Sp1 transcription factor]],<ref name = pmid12213324>{{cite journal | vauthors = Park SY, Shin HM, Han TH | title = Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter | journal = Molecular Immunology | volume = 39 | issue = 1-2 | pages = 25–30 | date = Sep 2002 | pmid = 12213324 | doi =  10.1016/s0161-5890(02)00055-x}}</ref>  and
* [[YWHAQ]].<ref name = pmid11433030>{{cite journal | vauthors = Choi SJ, Park SY, Han TH | title = 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation | journal = Nucleic Acids Research | volume = 29 | issue = 13 | pages = 2836–42 | date = Jul 2001 | pmid = 11433030 | pmc = 55772 | doi = 10.1093/nar/29.13.2836}}</ref>
{{Div col end}}


==See also==
== See also ==
* [[Mef2]]
* [[Mef2]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL | title = Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23 | journal = Genomics | volume = 29 | issue = 3 | pages = 704–11 | date = Oct 1995 | pmid = 8575763 | doi = 10.1006/geno.1995.9007 }}
| citations =
* {{cite journal | vauthors = Ornatsky OI, McDermott JC | title = MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells | journal = The Journal of Biological Chemistry | volume = 271 | issue = 40 | pages = 24927–33 | date = Oct 1996 | pmid = 8798771 | doi = 10.1074/jbc.271.40.24927 }}
*{{cite journal  | author=Breitbart RE, Liang CS, Smoot LB, ''et al.'' |title=A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. |journal=Development |volume=118 |issue= 4 |pages= 1095-106 |year= 1994 |pmid= 8269842 |doi=  }}
* {{cite journal | vauthors = Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA | title = Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1 | journal = Nucleic Acids Research | volume = 26 | issue = 20 | pages = 4771–7 | date = Oct 1998 | pmid = 9753748 | pmc = 147902 | doi = 10.1093/nar/26.20.4771 }}
*{{cite journal | author=Hobson GM, Krahe R, Garcia E, ''et al.'' |title=Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23. |journal=Genomics |volume=29 |issue= 3 |pages= 704-11 |year= 1996 |pmid= 8575763 |doi= 10.1006/geno.1995.9007 }}
* {{cite journal | vauthors = Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J | title = Regulation of the MEF2 family of transcription factors by p38 | journal = Molecular and Cellular Biology | volume = 19 | issue = 1 | pages = 21–30 | date = Jan 1999 | pmid = 9858528 | pmc = 83862 | doi = 10.1128/mcb.19.1.21 }}
*{{cite journal | author=Ornatsky OI, McDermott JC |title=MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24927-33 |year= 1996 |pmid= 8798771 |doi= }}
* {{cite journal | vauthors = Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ | title = HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7816–27 | date = Nov 1999 | pmid = 10523670 | pmc = 84849 | doi = 10.1128/mcb.19.11.7816 }}
*{{cite journal | author=Yang CC, Ornatsky OI, McDermott JC, ''et al.'' |title=Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1. |journal=Nucleic Acids Res. |volume=26 |issue= 20 |pages= 4771-7 |year= 1998 |pmid= 9753748 |doi= }}
* {{cite journal | vauthors = Lu J, McKinsey TA, Nicol RL, Olson EN | title = Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 8 | pages = 4070–5 | date = Apr 2000 | pmid = 10737771 | pmc = 18151 | doi = 10.1073/pnas.080064097 }}
*{{cite journal | author=Zhao M, New L, Kravchenko VV, ''et al.'' |title=Regulation of the MEF2 family of transcription factors by p38. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 21-30 |year= 1999 |pmid= 9858528 |doi= }}
* {{cite journal | vauthors = Kato Y, Zhao M, Morikawa A, Sugiyama T, Chakravortty D, Koide N, Yoshida T, Tapping RI, Yang Y, Yokochi T, Lee JD | title = Big mitogen-activated kinase regulates multiple members of the MEF2 protein family | journal = The Journal of Biological Chemistry | volume = 275 | issue = 24 | pages = 18534–40 | date = Jun 2000 | pmid = 10849446 | doi = 10.1074/jbc.M001573200 }}
*{{cite journal | author=Wang AH, Bertos NR, Vezmar M, ''et al.'' |title=HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7816-27 |year= 1999 |pmid= 10523670 |doi= }}
* {{cite journal | vauthors = Youn HD, Chatila TA, Liu JO | title = Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis | journal = The EMBO Journal | volume = 19 | issue = 16 | pages = 4323–31 | date = Aug 2000 | pmid = 10944115 | pmc = 302027 | doi = 10.1093/emboj/19.16.4323 }}
*{{cite journal | author=Lu J, McKinsey TA, Nicol RL, Olson EN |title=Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4070-5 |year= 2000 |pmid= 10737771 |doi= 10.1073/pnas.080064097 }}
* {{cite journal | vauthors = Slepak TI, Webster KA, Zang J, Prentice H, O'Dowd A, Hicks MN, Bishopric NH | title = Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D | journal = The Journal of Biological Chemistry | volume = 276 | issue = 10 | pages = 7575–85 | date = Mar 2001 | pmid = 11096067 | doi = 10.1074/jbc.M004625200 }}
*{{cite journal | author=Kato Y, Zhao M, Morikawa A, ''et al.'' |title=Big mitogen-activated kinase regulates multiple members of the MEF2 protein family. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18534-40 |year= 2000 |pmid= 10849446 |doi= 10.1074/jbc.M001573200 }}
* {{cite journal | vauthors = Choi SJ, Park SY, Han TH | title = 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation | journal = Nucleic Acids Research | volume = 29 | issue = 13 | pages = 2836–42 | date = Jul 2001 | pmid = 11433030 | pmc = 55772 | doi = 10.1093/nar/29.13.2836 }}
*{{cite journal | author=Youn HD, Chatila TA, Liu JO |title=Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. |journal=EMBO J. |volume=19 |issue= 16 |pages= 4323-31 |year= 2000 |pmid= 10944115 |doi= 10.1093/emboj/19.16.4323 }}
* {{cite journal | vauthors = Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA | title = Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 6 | pages = 3974–9 | date = Mar 2002 | pmid = 11904443 | pmc = 122633 | doi = 10.1073/pnas.022036399 }}
*{{cite journal | author=Slepak TI, Webster KA, Zang J, ''et al.'' |title=Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D. |journal=J. Biol. Chem. |volume=276 |issue= 10 |pages= 7575-85 |year= 2001 |pmid= 11096067 |doi= 10.1074/jbc.M004625200 }}
* {{cite journal | vauthors = Park SY, Shin HM, Han TH | title = Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter | journal = Molecular Immunology | volume = 39 | issue = 1-2 | pages = 25–30 | date = Sep 2002 | pmid = 12213324 | doi = 10.1016/S0161-5890(02)00055-X }}
*{{cite journal | author=Choi SJ, Park SY, Han TH |title=14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation. |journal=Nucleic Acids Res. |volume=29 |issue= 13 |pages= 2836-42 |year= 2001 |pmid= 11433030 |doi= }}
* {{cite journal | vauthors = Linseman DA, Bartley CM, Le SS, Laessig TA, Bouchard RJ, Meintzer MK, Li M, Heidenreich KA | title = Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival | journal = The Journal of Biological Chemistry | volume = 278 | issue = 42 | pages = 41472–81 | date = Oct 2003 | pmid = 12896970 | doi = 10.1074/jbc.M307245200 }}
*{{cite journal | author=Okamoto S, Li Z, Ju C, ''et al.'' |title=Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3974-9 |year= 2002 |pmid= 11904443 |doi= 10.1073/pnas.022036399 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Park SY, Shin HM, Han TH |title=Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter. |journal=Mol. Immunol. |volume=39 |issue= 1-2 |pages= 25-30 |year= 2002 |pmid= 12213324 |doi= }}
* {{cite journal | vauthors = Grégoire S, Yang XJ | title = Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors | journal = Molecular and Cellular Biology | volume = 25 | issue = 6 | pages = 2273–87 | date = Mar 2005 | pmid = 15743823 | pmc = 1061617 | doi = 10.1128/MCB.25.6.2273-2287.2005 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP | title = Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia | journal = Leukemia | volume = 19 | issue = 5 | pages = 806–13 | date = May 2005 | pmid = 15744350 | doi = 10.1038/sj.leu.2403684 }}
*{{cite journal | author=Linseman DA, Bartley CM, Le SS, ''et al.'' |title=Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival. |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 41472-81 |year= 2003 |pmid= 12896970 |doi= 10.1074/jbc.M307245200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Grégoire S, Yang XJ |title=Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. |journal=Mol. Cell. Biol. |volume=25 |issue= 6 |pages= 2273-87 |year= 2005 |pmid= 15743823 |doi= 10.1128/MCB.25.6.2273-2287.2005 }}
*{{cite journal | author=Prima V, Gore L, Caires A, ''et al.'' |title=Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. |journal=Leukemia |volume=19 |issue= 5 |pages= 806-13 |year= 2005 |pmid= 15744350 |doi= 10.1038/sj.leu.2403684 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|MEF2D+protein,+human}}
* {{MeshName|MEF2D+protein,+human}}
{{PDB Gallery|geneid=4209}}
{{Transcription factors|g4}}




{{protein-stub}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 06:22, 4 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.[1][2]

Interactions

MEF2D has been shown to interact with:

See also

References

  1. ↑ Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development. 118 (4): 1095–106. PMID 8269842.
  2. ↑ "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)".
  3. ↑ 3.0 3.1 Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.
  4. ↑ Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.
  5. ↑ Youn HD, Grozinger CM, Liu JO (Jul 2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". The Journal of Biological Chemistry. 275 (29): 22563–7. doi:10.1074/jbc.C000304200. PMID 10825153.
  6. ↑ Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771–7. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.
  7. ↑ Ornatsky OI, McDermott JC (Oct 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". The Journal of Biological Chemistry. 271 (40): 24927–33. doi:10.1074/jbc.271.40.24927. PMID 8798771.
  8. ↑ Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–31. doi:10.1093/emboj/19.16.4323. PMC 302027. PMID 10944115.
  9. ↑ Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology. 39 (1–2): 25–30. doi:10.1016/s0161-5890(02)00055-x. PMID 12213324.
  10. ↑ Choi SJ, Park SY, Han TH (Jul 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Research. 29 (13): 2836–42. doi:10.1093/nar/29.13.2836. PMC 55772. PMID 11433030.

Further reading

External links

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