ILF2: Difference between revisions

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Latest revision as of 15:22, 17 May 2018

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.^[1]^[2]

Function

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.^[2]

Interactions

ILF2 has been shown to interact with CDC5L^[3] and DNA-PKcs.^[4]

ILF2 and ILF3 have been identified as autoantigens in mice with induced lupus,^[5]^[6] in canine systemic rheumatic autoimmune disease,^[7]^[8] and as a rare finding in humans with autoimmune disease.^[9]

References

↑ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B (August 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". The Journal of Biological Chemistry. 269 (32): 20691–9. PMID 7519613.
↑ ^2.0 ^2.1 "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa".
↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
↑ Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
↑ Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. PMID 10574923.
↑ Kuroda Y, Ono N, Akaogi J, Nacionales DC, Yamasaki Y, Barker TT, Reeves WH, Satoh M (February 2006). "Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice". Toxicology. 218 (2–3): 186–96. doi:10.1016/j.tox.2005.10.011. PMID 16309812.
↑ Bremer HD, Landegren N, Sjöberg R, Hallgren Å, Renneker S, Lattwein E, Leonard D, Eloranta ML, Rönnblom L, Nordmark G, Nilsson P, Andersson G, Lilliehöök I, Lindblad-Toh K, Kämpe O, Hansson-Hamlin H (March 2018). "ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease". Scientific Reports. 8 (1): 4852. doi:10.1038/s41598-018-23034-w. PMID 29556082.
↑ Hanna, Bremer, (2018). Canine immune-mediated disease. Acta Universitatis agriculturae Sueciae. ISBN 978-91-7760-166-1.
↑ Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. PMID 10574923.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Marcoulatos P, Koussidis G, Mamuris Z, Velissariou V, Vamvakopoulos NC (December 1996). "Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates". Journal of Interferon & Cytokine Research. 16 (12): 1035–8. doi:10.1089/jir.1996.16.1035. PMID 8974006.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
Langland JO, Kao PN, Jacobs BL (May 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR". Biochemistry. 38 (19): 6361–8. doi:10.1021/bi982410u. PMID 10320367.
Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Parker LM, Fierro-Monti I, Mathews MB (August 2001). "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase". The Journal of Biological Chemistry. 276 (35): 32522–30. doi:10.1074/jbc.M104408200. PMID 11438540.
Reichman TW, Muñiz LC, Mathews MB (January 2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells". Molecular and Cellular Biology. 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMC 134226. PMID 11739746.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Shin HJ, Kim SS, Cho YH, Lee SG, Rho HM (March 2002). "Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA". Archives of Virology. 147 (3): 471–91. doi:10.1007/s007050200001. PMID 11958450.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (November 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Zhao G, Shi L, Qiu D, Hu H, Kao PN (May 2005). "NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function". Experimental Cell Research. 305 (2): 312–23. doi:10.1016/j.yexcr.2004.12.030. PMID 15817156.
Nie Y, Ding L, Kao PN, Braun R, Yang JH (August 2005). "ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing". Molecular and Cellular Biology. 25 (16): 6956–63. doi:10.1128/MCB.25.16.6956-6963.2005. PMC 1190226. PMID 16055709.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

ILF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid7519613-1] Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B (August 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". The Journal of Biological Chemistry. 269 (32): 20691–9. PMID 7519613.

[entrez-2] 2.0 ^2.1 "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa".

[pmid11101529-3] Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

[pmid9442054-4] Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.

[5] Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. PMID 10574923.

[6] Kuroda Y, Ono N, Akaogi J, Nacionales DC, Yamasaki Y, Barker TT, Reeves WH, Satoh M (February 2006). "Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice". Toxicology. 218 (2–3): 186–96. doi:10.1016/j.tox.2005.10.011. PMID 16309812.

[7] Bremer HD, Landegren N, Sjöberg R, Hallgren Å, Renneker S, Lattwein E, Leonard D, Eloranta ML, Rönnblom L, Nordmark G, Nilsson P, Andersson G, Lilliehöök I, Lindblad-Toh K, Kämpe O, Hansson-Hamlin H (March 2018). "ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease". Scientific Reports. 8 (1): 4852. doi:10.1038/s41598-018-23034-w. PMID 29556082.

[8] Hanna, Bremer, (2018). Canine immune-mediated disease. Acta Universitatis agriculturae Sueciae. ISBN 978-91-7760-166-1.

[9] Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. PMID 10574923.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Interleukin enhancer-binding factor 2''' is a [[protein]] that in humans is encoded by the ''ILF2'' [[gene]].<ref name="pmid7519613">{{cite journal | vauthors = Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B | title = Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90 | journal = The Journal of Biological Chemistry | volume = 269 | issue = 32 | pages = 20691–9 | date = August 1994 | pmid = 7519613 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3608| access-date = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Interleukin enhancer binding factor 2, 45kDa
- | HGNCid = 6037
- | Symbol = ILF2
- | AltSymbols =; MGC8391; NF45; PRO3063
- | OMIM = 603181
- | ECnumber =
- | Homologene = 26894
- | MGIid = 1915031
- | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003725 |text = double-stranded RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 3608
-    | Hs_Ensembl = ENSG00000143621
-    | Hs_RefseqProtein = NP_004506
-    | Hs_RefseqmRNA = NM_004515
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 151900905
-    | Hs_GenLoc_end = 151910148
-    | Hs_Uniprot = Q12905
-    | Mm_EntrezGene = 67781
-    | Mm_Ensembl = ENSMUSG00000001016
-    | Mm_RefseqmRNA = NM_026374
-    | Mm_RefseqProtein = NP_080650
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 3
-    | Mm_GenLoc_start = 90562128
-    | Mm_GenLoc_end = 90574306
-    | Mm_Uniprot = Q3UXI9
-  }}
-}}
-'''Interleukin enhancer binding factor 2, 45kDa''', also known as '''ILF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3608| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.<ref name="entrez">{{cite web | title = Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3608| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+ILF2 has been shown to [[Protein-protein interaction|interact]] with [[CDC5L]]<ref name=pmid11101529>{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = December 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}</ref> and [[DNA-PKcs]].<ref name=pmid9442054>{{cite journal | vauthors = Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP | title = DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 4 | pages = 2136–45 | date = January 1998 | pmid = 9442054 | doi = 10.1074/jbc.273.4.2136 }}</ref>
+ILF2 and ILF3 have been identified as autoantigens in mice with induced lupus,<ref>{{cite journal | vauthors = Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH | title = Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity | journal = The Journal of Biological Chemistry | volume = 274 | issue = 49 | pages = 34598–604 | date = December 1999 | pmid = 10574923 }}</ref><ref>{{cite journal | vauthors = Kuroda Y, Ono N, Akaogi J, Nacionales DC, Yamasaki Y, Barker TT, Reeves WH, Satoh M | title = Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice | journal = Toxicology | volume = 218 | issue = 2-3 | pages = 186–96 | date = February 2006 | pmid = 16309812 | doi = 10.1016/j.tox.2005.10.011 }}</ref> in canine systemic rheumatic  autoimmune disease,<ref>{{cite journal | vauthors = Bremer HD, Landegren N, Sjöberg R, Hallgren Å, Renneker S, Lattwein E, Leonard D, Eloranta ML, Rönnblom L, Nordmark G, Nilsson P, Andersson G, Lilliehöök I, Lindblad-Toh K, Kämpe O, Hansson-Hamlin H | title = ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease | journal = Scientific Reports | volume = 8 | issue = 1 | pages = 4852 | date = March 2018 | pmid = 29556082 | doi = 10.1038/s41598-018-23034-w }}</ref><ref>{{cite book|last1=Hanna|first1=Bremer,|title=Canine immune-mediated disease|date=2018|publisher=Acta Universitatis agriculturae Sueciae|isbn=978-91-7760-166-1|url=https://pub.epsilon.slu.se/15432/|language=en}}</ref> and as a rare finding in humans with autoimmune disease.<ref>{{cite journal | vauthors = Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH | title = Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity | journal = The Journal of Biological Chemistry | volume = 274 | issue = 49 | pages = 34598–604 | date = December 1999 | pmid = 10574923 }}</ref>
+== References ==
+{{reflist}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
-| citations =
+* {{cite journal | vauthors = Marcoulatos P, Koussidis G, Mamuris Z, Velissariou V, Vamvakopoulos NC | title = Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates | journal = Journal of Interferon & Cytokine Research | volume = 16 | issue = 12 | pages = 1035–8 | date = December 1996 | pmid = 8974006 | doi = 10.1089/jir.1996.16.1035 }}
-*{{cite journal  | author=Kao PN, Chen L, Brock G, ''et al.'' |title=Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. |journal=J. Biol. Chem. |volume=269 |issue= 32 |pages= 20691-9 |year= 1994 |pmid= 7519613 |doi=  }}
+* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+* {{cite journal | vauthors = Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP | title = DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 4 | pages = 2136–45 | date = January 1998 | pmid = 9442054 | doi = 10.1074/jbc.273.4.2136 }}
-*{{cite journal  | author=Marcoulatos P, Koussidis G, Mamuris Z, ''et al.'' |title=Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates. |journal=J. Interferon Cytokine Res. |volume=16 |issue= 12 |pages= 1035-8 |year= 1997 |pmid= 8974006 |doi=  }}
+* {{cite journal | vauthors = Langland JO, Kao PN, Jacobs BL | title = Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR | journal = Biochemistry | volume = 38 | issue = 19 | pages = 6361–8 | date = May 1999 | pmid = 10320367 | doi = 10.1021/bi982410u }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+* {{cite journal | vauthors = Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH | title = Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity | journal = The Journal of Biological Chemistry | volume = 274 | issue = 49 | pages = 34598–604 | date = December 1999 | pmid = 10574923 | doi = 10.1074/jbc.274.49.34598 }}
-*{{cite journal  | author=Ting NS, Kao PN, Chan DW, ''et al.'' |title=DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 2136-45 |year= 1998 |pmid= 9442054 |doi=  }}
+* {{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = December 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
-*{{cite journal  | author=Langland JO, Kao PN, Jacobs BL |title=Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR. |journal=Biochemistry |volume=38 |issue= 19 |pages= 6361-8 |year= 1999 |pmid= 10320367 |doi= 10.1021/bi982410u }}
+* {{cite journal | vauthors = Parker LM, Fierro-Monti I, Mathews MB | title = Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 32522–30 | date = August 2001 | pmid = 11438540 | doi = 10.1074/jbc.M104408200 }}
-*{{cite journal  | author=Satoh M, Shaheen VM, Kao PN, ''et al.'' |title=Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34598-604 |year= 2000 |pmid= 10574923 |doi=  }}
+* {{cite journal | vauthors = Reichman TW, Muñiz LC, Mathews MB | title = The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells | journal = Molecular and Cellular Biology | volume = 22 | issue = 1 | pages = 343–56 | date = January 2002 | pmid = 11739746 | pmc = 134226 | doi = 10.1128/MCB.22.1.343-356.2002 }}
-*{{cite journal  | author=Ajuh P, Kuster B, Panov K, ''et al.'' |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6569-81 |year= 2001 |pmid= 11101529 |doi= 10.1093/emboj/19.23.6569 }}
+* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = January 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
-*{{cite journal  | author=Parker LM, Fierro-Monti I, Mathews MB |title=Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32522-30 |year= 2001 |pmid= 11438540 |doi= 10.1074/jbc.M104408200 }}
+* {{cite journal | vauthors = Shin HJ, Kim SS, Cho YH, Lee SG, Rho HM | title = Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA | journal = Archives of Virology | volume = 147 | issue = 3 | pages = 471–91 | date = March 2002 | pmid = 11958450 | doi = 10.1007/s007050200001 }}
-*{{cite journal  | author=Reichman TW, Muñiz LC, Mathews MB |title=The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 1 |pages= 343-56 |year= 2002 |pmid= 11739746 |doi=  }}
+* {{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4100–9 | date = November 2002 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}
-*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
+* {{cite journal | vauthors = Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG | title = Regulation of alternative splicing by SRrp86 and its interacting proteins | journal = Molecular and Cellular Biology | volume = 23 | issue = 21 | pages = 7437–47 | date = November 2003 | pmid = 14559993 | pmc = 207616 | doi = 10.1128/MCB.23.21.7437-7447.2003 }}
-*{{cite journal  | author=Shin HJ, Kim SS, Cho YH, ''et al.'' |title=Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA. |journal=Arch. Virol. |volume=147 |issue= 3 |pages= 471-91 |year= 2002 |pmid= 11958450 |doi=  }}
+* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = January 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
-*{{cite journal  | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
+* {{cite journal | vauthors = Zhao G, Shi L, Qiu D, Hu H, Kao PN | title = NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function | journal = Experimental Cell Research | volume = 305 | issue = 2 | pages = 312–23 | date = May 2005 | pmid = 15817156 | doi = 10.1016/j.yexcr.2004.12.030 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Nie Y, Ding L, Kao PN, Braun R, Yang JH | title = ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing | journal = Molecular and Cellular Biology | volume = 25 | issue = 16 | pages = 6956–63 | date = August 2005 | pmid = 16055709 | pmc = 1190226 | doi = 10.1128/MCB.25.16.6956-6963.2005 }}
-*{{cite journal  | author=Li J, Hawkins IC, Harvey CD, ''et al.'' |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437-47 |year= 2003 |pmid= 14559993 |doi=  }}
+* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | authorlink30 = Huda Zoghbi }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
-*{{cite journal  | author=Zhao G, Shi L, Qiu D, ''et al.'' |title=NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function. |journal=Exp. Cell Res. |volume=305 |issue= 2 |pages= 312-23 |year= 2005 |pmid= 15817156 |doi= 10.1016/j.yexcr.2004.12.030 }}
-*{{cite journal  | author=Nie Y, Ding L, Kao PN, ''et al.'' |title=ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. |journal=Mol. Cell. Biol. |volume=25 |issue= 16 |pages= 6956-63 |year= 2005 |pmid= 16055709 |doi= 10.1128/MCB.25.16.6956-6963.2005 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-}}
 {{refend}}
@@ Line 85: / Line 39: @@
 * {{MeshName|ILF2+protein,+human}}
+{{NLM content}}
+{{Transcription factors|g2}}
-{{protein-stub}}
-{{NLM content}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-1-stub}}

ILF2: Difference between revisions

Latest revision as of 15:22, 17 May 2018

Contents

Function

Interactions

References

Further reading

External links

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