IFI16: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Gamma-interferon-inducible protein Ifi-16''' (Ifi-16) also known as '''interferon-inducible myeloid differentiation transcriptional activator''' is a [[protein]] that in humans is encoded by the ''IFI16'' [[gene]].<ref name="pmid1526658">{{cite journal |vauthors=Trapani JA, Browne KA, Dawson MJ, Ramsay RG, Eddy RL, Show TB, White PC, Dupont B | title = A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells | journal = Immunogenetics | volume = 36 | issue = 6 | pages = 369–76 |date=Oct 1992 | pmid = 1526658 | pmc =  | doi =  10.1007/bf00218044}}</ref><ref name="pmid7959953">{{cite journal |vauthors=Trapani JA, Dawson M, Apostolidis VA, Browne KA | title = Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization | journal = Immunogenetics | volume = 40 | issue = 6 | pages = 415–24 |date=Dec 1994 | pmid = 7959953 | pmc = | doi = 10.1007/bf00177824}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IFI16 interferon, gamma-inducible protein 16| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3428| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_IFI16_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2oq0.
| PDB = {{PDB2|2oq0}}
| Name = Interferon, gamma-inducible protein 16
| HGNCid = 5395
| Symbol = IFI16
| AltSymbols =; IFNGIP1; MGC9466; PYHIN2
| OMIM = 147586
| ECnumber = 
| Homologene = 48354
| MGIid = 96429
| GeneAtlas_image1 = PBB_GE_IFI16_206332_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_IFI16_208965_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_IFI16_208966_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0030099 |text = myeloid cell differentiation}} {{GNF_GO|id=GO:0030224 |text = monocyte differentiation}} {{GNF_GO|id=GO:0042771 |text = DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3428
    | Hs_Ensembl = ENSG00000163565
    | Hs_RefseqProtein = NP_005522
    | Hs_RefseqmRNA = NM_005531
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 157236382
    | Hs_GenLoc_end = 157291569
    | Hs_Uniprot = Q16666
    | Mm_EntrezGene = 15951
    | Mm_Ensembl = ENSMUSG00000054203
    | Mm_RefseqmRNA = XM_001002287
    | Mm_RefseqProtein = XP_001002287
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 175848661
    | Mm_GenLoc_end = 175868430
    | Mm_Uniprot = Q3TM07
  }}
}}
'''Interferon, gamma-inducible protein 16''', also known as '''IFI16''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IFI16 interferon, gamma-inducible protein 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3428| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of [[cytokine]]s. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the [[nucleoplasm]] and [[nucleolus|nucleoli]], and interacts with [[p53]],<ref>{{Cite journal|last=Liao|first=Jack C. C.|last2=Lam|first2=Robert|last3=Brazda|first3=Vaclav|last4=Duan|first4=Shili|last5=Ravichandran|first5=Mani|last6=Ma|first6=Justin|last7=Xiao|first7=Ting|last8=Tempel|first8=Wolfram|last9=Zuo|first9=Xiaobing|date=2011-03-09|title=Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53|pmid=21397192|journal=Structure|volume=19|issue=3|pages=418–429|doi=10.1016/j.str.2010.12.015|issn=1878-4186|pmc=3760383}}</ref><ref>{{Cite journal|last=Ouchi|first=Mutsuko|last2=Ouchi|first2=Toru|date=2008-01-01|title=Role of IFI16 in DNA damage and checkpoint|pmid=17981541|journal=Frontiers in Bioscience|volume=13|pages=236–239|issn=1093-9946|doi=10.2741/2673}}</ref> [[retinoblastoma protein|retinoblastoma-1]] and [[BRCA1]].<ref>{{Cite journal|last=Dutta|first=Dipanjan|last2=Dutta|first2=Sujoy|last3=Veettil|first3=Mohanan Valiya|last4=Roy|first4=Arunava|last5=Ansari|first5=Mairaj Ahmed|last6=Iqbal|first6=Jawed|last7=Chikoti|first7=Leela|last8=Kumar|first8=Binod|last9=Johnson|first9=Karen E.|date=2015-06-01|title=BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses|pmid=26121674|journal=PLOS Pathogens|volume=11|issue=6|pages=e1005030|doi=10.1371/journal.ppat.1005030|issn=1553-7374|pmc=4487893}}</ref> It modulates p53 function, and inhibits cell growth in the [[MAPK/ERK pathway|Ras/Raf signaling pathway]].<ref name="entrez"/> IFI16 has been shown to play a role in the sensing of intracellular [[DNA]]<ref name="pmid20890285">{{cite journal |vauthors=Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG | title = IFI16 is an innate immune sensor for intracellular DNA | journal = Nat. Immunol. | volume = 11 | issue = 11 | pages = 997–1004 | year = 2010 | pmid = 20890285 | pmc = 3142795 | doi = 10.1038/ni.1932 }}</ref> - a hallmark of virally infected cells - and has also been linked to the death of [[HIV]]-infected [[T helper cell|helper CD4 T cell]]<nowiki/>s by [[pyroptosis|proptosis]], a highly inflammatory form of programmed cell death.<ref name="pmid24356113">{{cite journal |vauthors=Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC | title = IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV | journal = Science | volume = 343 | issue = 6169 | pages = 428–32 | year = 2014 | pmid = 24356113 | doi = 10.1126/science.1243640 | pmc=3976200}}</ref><ref name="pmid24356306">{{cite journal |vauthors=Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC | title = Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection | journal = Nature | volume = 505 | issue = 7484 | pages = 509–14 | year = 2014 | pmid = 24356306 | doi = 10.1038/nature12940 | pmc=4047036}}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.<ref name="entrez">{{cite web | title = Entrez Gene: IFI16 interferon, gamma-inducible protein 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3428| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Dawson MJ, Trapani JA |title=IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. |journal=J. Cell. Biochem. |volume=57 |issue= 1 |pages= 39–51 |year= 1995 |pmid= 7536752 |doi= 10.1002/jcb.240570106 }}
| citations =
*{{cite journal   |vauthors=Dawson MJ, Trapani JA, Briggs RC, etal |title=The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. |journal=Immunogenetics |volume=41 |issue= 1 |pages= 40–3 |year= 1995 |pmid= 7806273 |doi=10.1007/BF00188431  }}
*{{cite journal  | author=Trapani JA, Browne KA, Dawson MJ, ''et al.'' |title=A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells. |journal=Immunogenetics |volume=36 |issue= 6 |pages= 369-76 |year= 1992 |pmid= 1526658 |doi= }}
*{{cite journal  |vauthors=Johnstone RW, Kerry JA, Trapani JA |title=The human interferon-inducible protein, IFI 16, is a repressor of transcription. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 17172–7 |year= 1998 |pmid= 9642285 |doi=10.1074/jbc.273.27.17172 }}
*{{cite journal | author=Dawson MJ, Trapani JA |title=IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. |journal=J. Cell. Biochem. |volume=57 |issue= 1 |pages= 39-51 |year= 1995 |pmid= 7536752 |doi= 10.1002/jcb.240570106 }}
*{{cite journal  |vauthors=Johnstone RW, Kershaw MH, Trapani JA |title=Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. |journal=Biochemistry |volume=37 |issue= 34 |pages= 11924–31 |year= 1998 |pmid= 9718316 |doi= 10.1021/bi981069a }}
*{{cite journal  | author=Dawson MJ, Trapani JA, Briggs RC, ''et al.'' |title=The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. |journal=Immunogenetics |volume=41 |issue= 1 |pages= 40-3 |year= 1995 |pmid= 7806273 |doi=  }}
*{{cite journal  |vauthors=Dawson MJ, Elwood NJ, Johnstone RW, Trapani JA |title=The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations. |journal=J. Leukoc. Biol. |volume=64 |issue= 4 |pages= 546–54 |year= 1998 |pmid= 9766636 |doi=  }}
*{{cite journal  | author=Trapani JA, Dawson M, Apostolidis VA, Browne KA |title=Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization. |journal=Immunogenetics |volume=40 |issue= 6 |pages= 415-24 |year= 1994 |pmid= 7959953 |doi= }}
*{{cite journal   |vauthors=Briggs LJ, Johnstone RW, Elliot RM, etal |title=Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16. |journal=Biochem. J. |volume=353 |issue= Pt 1 |pages= 69–77 |year= 2001 |pmid= 11115400 |doi=10.1042/0264-6021:3530069  | pmc=1221544  }}
*{{cite journal  | author=Johnstone RW, Kerry JA, Trapani JA |title=The human interferon-inducible protein, IFI 16, is a repressor of transcription. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 17172-7 |year= 1998 |pmid= 9642285 |doi=  }}
*{{cite journal  |vauthors=Johnstone RW, Wei W, Greenway A, Trapani JA |title=Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. |journal=Oncogene |volume=19 |issue= 52 |pages= 6033–42 |year= 2001 |pmid= 11146555 |doi= 10.1038/sj.onc.1204005 }}
*{{cite journal | author=Johnstone RW, Kershaw MH, Trapani JA |title=Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. |journal=Biochemistry |volume=37 |issue= 34 |pages= 11924-31 |year= 1998 |pmid= 9718316 |doi= 10.1021/bi981069a }}
*{{cite journal   |vauthors=Gariglio M, Azzimonti B, Pagano M, etal |title=Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 7 |pages= 815–21 |year= 2003 |pmid= 12184920 |doi= 10.1089/107999002320271413 }}
*{{cite journal  | author=Dawson MJ, Elwood NJ, Johnstone RW, Trapani JA |title=The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations. |journal=J. Leukoc. Biol. |volume=64 |issue= 4 |pages= 546-54 |year= 1998 |pmid= 9766636 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Briggs LJ, Johnstone RW, Elliot RM, ''et al.'' |title=Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16. |journal=Biochem. J. |volume=353 |issue= Pt 1 |pages= 69-77 |year= 2001 |pmid= 11115400 |doi= }}
*{{cite journal   |vauthors=Izmailova E, Bertley FM, Huang Q, etal |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
*{{cite journal | author=Johnstone RW, Wei W, Greenway A, Trapani JA |title=Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. |journal=Oncogene |volume=19 |issue= 52 |pages= 6033-42 |year= 2001 |pmid= 11146555 |doi= 10.1038/sj.onc.1204005 }}
*{{cite journal   |vauthors=Clarke CJ, Apostolidis V, Hii LL, etal |title=Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16. |journal=J. Cell. Biochem. |volume=89 |issue= 1 |pages= 80–93 |year= 2003 |pmid= 12682910 |doi= 10.1002/jcb.10475 }}
*{{cite journal | author=Gariglio M, Azzimonti B, Pagano M, ''et al.'' |title=Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 7 |pages= 815-21 |year= 2003 |pmid= 12184920 |doi= 10.1089/107999002320271413 }}
*{{cite journal   |vauthors=Xin H, Curry J, Johnstone RW, etal |title=Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. |journal=Oncogene |volume=22 |issue= 31 |pages= 4831–40 |year= 2003 |pmid= 12894224 |doi= 10.1038/sj.onc.1206754 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Kwak JC, Ongusaha PP, Ouchi T, Lee SW |title=IFI16 as a negative regulator in the regulation of p53 and p21(Waf1). |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 40899–904 |year= 2003 |pmid= 12925527 |doi= 10.1074/jbc.M308012200 }}
*{{cite journal | author=Izmailova E, Bertley FM, Huang Q, ''et al.'' |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191-7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
*{{cite journal   |vauthors=Aglipay JA, Lee SW, Okada S, etal |title=A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. |journal=Oncogene |volume=22 |issue= 55 |pages= 8931–8 |year= 2004 |pmid= 14654789 |doi= 10.1038/sj.onc.1207057 }}
*{{cite journal  | author=Clarke CJ, Apostolidis V, Hii LL, ''et al.'' |title=Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16. |journal=J. Cell. Biochem. |volume=89 |issue= 1 |pages= 80-93 |year= 2003 |pmid= 12682910 |doi= 10.1002/jcb.10475 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Xin H, Curry J, Johnstone RW, ''et al.'' |title=Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. |journal=Oncogene |volume=22 |issue= 31 |pages= 4831-40 |year= 2003 |pmid= 12894224 |doi= 10.1038/sj.onc.1206754 }}
*{{cite journal   |vauthors=Raffaella R, Gioia D, De Andrea M, etal |title=The interferon-inducible IFI16 gene inhibits tube morphogenesis and proliferation of primary, but not HPV16 E6/E7-immortalized human endothelial cells. |journal=Exp. Cell Res. |volume=293 |issue= 2 |pages= 331–45 |year= 2004 |pmid= 14729471 |doi=10.1016/j.yexcr.2003.10.014  }}
*{{cite journal | author=Kwak JC, Ongusaha PP, Ouchi T, Lee SW |title=IFI16 as a negative regulator in the regulation of p53 and p21(Waf1). |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 40899-904 |year= 2003 |pmid= 12925527 |doi= 10.1074/jbc.M308012200 }}
*{{cite journal   |vauthors=Fujiuchi N, Aglipay JA, Ohtsuka T, etal |title=Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 20339–44 |year= 2004 |pmid= 14990579 |doi= 10.1074/jbc.M400344200 }}
*{{cite journal | author=Aglipay JA, Lee SW, Okada S, ''et al.'' |title=A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. |journal=Oncogene |volume=22 |issue= 55 |pages= 8931-8 |year= 2004 |pmid= 14654789 |doi= 10.1038/sj.onc.1207057 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Raffaella R, Gioia D, De Andrea M, ''et al.'' |title=The interferon-inducible IFI16 gene inhibits tube morphogenesis and proliferation of primary, but not HPV16 E6/E7-immortalized human endothelial cells. |journal=Exp. Cell Res. |volume=293 |issue= 2 |pages= 331-45 |year= 2004 |pmid= 14729471 |doi=  }}
*{{cite journal  | author=Fujiuchi N, Aglipay JA, Ohtsuka T, ''et al.'' |title=Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 20339-44 |year= 2004 |pmid= 14990579 |doi= 10.1074/jbc.M400344200 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|IFI16+protein,+human}}
* {{MeshName|IFI16+protein,+human}}


{{PDB Gallery|geneid=3428}}
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{{protein-stub}}
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[[Category:Transcription factors]]
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Revision as of 15:33, 26 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.[1][2][3]

Function

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53,[4][5] retinoblastoma-1 and BRCA1.[6] It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.[3] IFI16 has been shown to play a role in the sensing of intracellular DNA[7] - a hallmark of virally infected cells - and has also been linked to the death of HIV-infected helper CD4 T cells by proptosis, a highly inflammatory form of programmed cell death.[8][9]

References

  1. ↑ Trapani JA, Browne KA, Dawson MJ, Ramsay RG, Eddy RL, Show TB, White PC, Dupont B (Oct 1992). "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells". Immunogenetics. 36 (6): 369–76. doi:10.1007/bf00218044. PMID 1526658.
  2. ↑ Trapani JA, Dawson M, Apostolidis VA, Browne KA (Dec 1994). "Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization". Immunogenetics. 40 (6): 415–24. doi:10.1007/bf00177824. PMID 7959953.
  3. ↑ 3.0 3.1 "Entrez Gene: IFI16 interferon, gamma-inducible protein 16".
  4. ↑ Liao, Jack C. C.; Lam, Robert; Brazda, Vaclav; Duan, Shili; Ravichandran, Mani; Ma, Justin; Xiao, Ting; Tempel, Wolfram; Zuo, Xiaobing (2011-03-09). "Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53". Structure. 19 (3): 418–429. doi:10.1016/j.str.2010.12.015. ISSN 1878-4186. PMC 3760383. PMID 21397192.
  5. ↑ Ouchi, Mutsuko; Ouchi, Toru (2008-01-01). "Role of IFI16 in DNA damage and checkpoint". Frontiers in Bioscience. 13: 236–239. doi:10.2741/2673. ISSN 1093-9946. PMID 17981541.
  6. ↑ Dutta, Dipanjan; Dutta, Sujoy; Veettil, Mohanan Valiya; Roy, Arunava; Ansari, Mairaj Ahmed; Iqbal, Jawed; Chikoti, Leela; Kumar, Binod; Johnson, Karen E. (2015-06-01). "BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses". PLOS Pathogens. 11 (6): e1005030. doi:10.1371/journal.ppat.1005030. ISSN 1553-7374. PMC 4487893. PMID 26121674.
  7. ↑ Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG (2010). "IFI16 is an innate immune sensor for intracellular DNA". Nat. Immunol. 11 (11): 997–1004. doi:10.1038/ni.1932. PMC 3142795. PMID 20890285.
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  9. ↑ Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC (2014). "Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection". Nature. 505 (7484): 509–14. doi:10.1038/nature12940. PMC 4047036. PMID 24356306.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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