HOXB6

Homeobox B6
File:PBB Protein HOXB6 image.jpg PDB rendering based on 1ahd.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ahd​, 1hom​, 1san​, 2hoa​, 9ant​
Identifiers
Symbols	HOXB6 ; HOX2; HOX2B; HU-2; Hox-2.2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7366
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Homeobox B6, also known as HOXB6, is a human gene.

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.

See also

• Homeobox

Further reading

• Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
• Kaur S, Singh G, Stock JL; et al. (1992). "Dominant mutation of the murine Hox-2.2 gene results in developmental abnormalities". J. Exp. Zool. 264 (3): 323–36. doi:10.1002/jez.1402640311. PMID 1358998.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shen WF, Detmer K, Simonitch-Eason TA; et al. (1991). "Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues". Nucleic Acids Res. 19 (3): 539–45. PMID 1672751.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
• Peverali FA, D'Esposito M, Acampora D; et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation. 45 (1): 61–9. PMID 1981366.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giampaolo A, Acampora D, Zappavigna V; et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–7. PMID 2570724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shen WF, Largman C, Lowney P; et al. (1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8536–40. PMID 2573064.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Acampora D, D'Esposito M, Faiella A; et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boncinelli E, Acampora D, Pannese M; et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. PMID 2576652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murphy PD, Ferguson-Smith AC, Miki T; et al. (1987). "A moderately frequent RFLP identified by both SacI and BanII with a probe from the HOX2 locus in man (17q11-17q22)". Nucleic Acids Res. 15 (15): 6311. PMID 2888083.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levine M, Rubin GM, Tjian R (1984). "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila". Cell. 38 (3): 667–73. PMID 6091895.CS1 maint: Multiple names: authors list (link)
• Chang CP, Shen WF, Rozenfeld S; et al. (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. PMID 7729685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Castronovo V, Kusaka M, Chariot A; et al. (1994). "Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype". Biochem. Pharmacol. 47 (1): 137–43. PMID 7906121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Apiou F, Flagiello D, Cillo C; et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. PMID 8646877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sawcer S, Jones HB, Feakes R; et al. (1996). "A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22". Nat. Genet. 13 (4): 464–8. doi:10.1038/ng0896-464. PMID 8696343.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zimmermann F, Rich IN (1997). "Mammalian homeobox B6 expression can be correlated with erythropoietin production sites and erythropoiesis during development, but not with hematopoietic or nonhematopoietic stem cell populations". Blood. 89 (8): 2723–35. PMID 9108390.
• Vider BZ, Zimber A, Hirsch D; et al. (1997). "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression". Biochem. Biophys. Res. Commun. 232 (3): 742–8. doi:10.1006/bbrc.1997.6364. PMID 9126347.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohnishi K, Tobita T, Sinjo K; et al. (1999). "Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation". Leuk. Lymphoma. 31 (5–6): 599–608. PMID 9922051.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fienberg AA, Nordstedt C, Belting HG; et al. (1999). "Phylogenetically conserved CK-II phosphorylation site of the murine homeodomain protein Hoxb-6". J. Exp. Zool. 285 (1): 76–84. PMID 10327653.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vider BZ, Zimber A, Chastre E; et al. (2000). "Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines". Biochem. Biophys. Res. Commun. 272 (2): 513–8. doi:10.1006/bbrc.2000.2804. PMID 10833444.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HOXB6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.