HOXB5

Homeobox B5
File:PBB Protein HOXB5 image.jpg PDB rendering based on 1hom.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1hom​, 1san​
Identifiers
Symbols	HOXB5 ; HOX2; HHO.C10; HOX2A; HU-1; Hox2.1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37585
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Homeobox B5, also known as HOXB5, is a human gene.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.

See also

• Homeobox

Further reading

• Galang CK, Hauser CA (1992). "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product". New Biol. 4 (5): 558–68. PMID 1355360.
• Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
• Peverali FA, D'Esposito M, Acampora D; et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation. 45 (1): 61–9. PMID 1981366.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giampaolo A, Acampora D, Zappavigna V; et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–7. PMID 2570724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Acampora D, D'Esposito M, Faiella A; et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boncinelli E, Acampora D, Pannese M; et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. PMID 2576652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. PMID 2878432.CS1 maint: Multiple names: authors list (link)
• Hart CP, Awgulewitsch A, Fainsod A; et al. (1986). "Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus". Cell. 43 (1): 9–18. PMID 3000607.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu WM, Gorman PA, Rider SH; et al. (1988). "Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer". Proc. Natl. Acad. Sci. U.S.A. 85 (22): 8563–7. PMID 3186746.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simeone A, Mavilio F, Bottero L; et al. (1986). "A human homoeo box gene specifically expressed in spinal cord during embryonic development". Nature. 320 (6064): 763–5. doi:10.1038/320763a0. PMID 3453105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hauser CA, Joyner AL, Klein RD; et al. (1986). "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos". Cell. 43 (1): 19–28. PMID 4075393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levine M, Rubin GM, Tjian R (1984). "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila". Cell. 38 (3): 667–73. PMID 6091895.CS1 maint: Multiple names: authors list (link)
• Galang CK, Hauser CA (1993). "Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro". Mol. Cell. Biol. 13 (8): 4609–17. PMID 8101633.
• Apiou F, Flagiello D, Cillo C; et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. PMID 8646877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuliev A, Kukharenko V, Morozov G; et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". J. Assist. Reprod. Genet. 13 (2): 177–81. PMID 8688592.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakach M, Safaei R (1997). "Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos". Int. J. Dev. Neurosci. 14 (5): 567–73. PMID 8930688.
• Archavachotikul K, Ciccone TJ, Chinoy MR; et al. (2002). "Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (3): L359–69. doi:10.1152/ajplung.00400.2000. PMID 11839528.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kosaki K, Kosaki R, Suzuki T; et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HOXB5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.