HOXB2
| Homeobox B2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | HOXB2 ; HOX2; HOX2H; Hox-2.8; K8 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 37584 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
 | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Homeobox B2, also known as HOXB2, is a human gene.[1]
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.[1]
See also
References
Further reading
- Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. PMID 1358459.
- Lavelle D, Ducksworth J, Eves E; et al. (1991). "A homeodomain protein binds to gamma-globin gene regulatory sequences". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7318–22. PMID 1871139.
- McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. PMID 1973146.
- Giampaolo A, Acampora D, Zappavigna V; et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–7. PMID 2570724.
- Acampora D, D'Esposito M, Faiella A; et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. PMID 2574852.
- Boncinelli E, Acampora D, Pannese M; et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. PMID 2576652.
- Kongsuwan K, Webb E, Housiaux P, Adams JM (1988). "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages". EMBO J. 7 (7): 2131–8. PMID 2901346.
- Vieille-Grosjean I, Huber P (1995). "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells". J. Biol. Chem. 270 (9): 4544–50. PMID 7876223.
- Guazzi S, Lonigro R, Pintonello L; et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339–47. PMID 7913891.
- Guazzi S, Pintonello ML, Viganò A, Boncinelli E (1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". J. Biol. Chem. 273 (18): 11092–9. PMID 9556594.
- Davenne M, Maconochie MK, Neun R; et al. (1999). "Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain". Neuron. 22 (4): 677–91. PMID 10230789.
- Case SS, Huber P, Lloyd JA (2000). "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation". DNA Cell Biol. 18 (11): 805–17. doi:10.1089/104454999314809. PMID 10595394.
- Golpon HA, Geraci MW, Moore MD; et al. (2001). "HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema". Am. J. Pathol. 158 (3): 955–66. PMID 11238043.
- Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930.
- Liu X, Zhang X (2002). "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells". Chin. J. Traumatol. 5 (1): 12–5. PMID 11835749.
- Kosaki K, Kosaki R, Suzuki T; et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ivins S, Pemberton K, Guidez F; et al. (2003). "Regulation of Hoxb2 by APL-associated PLZF protein". Oncogene. 22 (24): 3685–97. doi:10.1038/sj.onc.1206328. PMID 12802276.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Segara D, Biankin AV, Kench JG; et al. (2005). "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia". Clin. Cancer Res. 11 (9): 3587–96. doi:10.1158/1078-0432.CCR-04-1813. PMID 15867264.
External links
- HOXB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |