HIC1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Hypermethylated in cancer 1 protein''' is a [[protein]] that in humans is encoded by the ''HIC1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIC1 hypermethylated in cancer 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3090| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Hypermethylated in cancer 1
| HGNCid = 4909
| Symbol = HIC1
| AltSymbols =; ZBTB29; hic-1
| OMIM = 603825
| ECnumber = 
| Homologene = 4740
| MGIid = 1338010
| GeneAtlas_image1 = PBB_GE_HIC1_208461_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3090
    | Hs_Ensembl = ENSG00000177374
    | Hs_RefseqProtein = NP_006488
    | Hs_RefseqmRNA = NM_006497
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 1906354
    | Hs_GenLoc_end = 1909070
    | Hs_Uniprot = Q14526
    | Mm_EntrezGene = 15248
    | Mm_Ensembl = ENSMUSG00000043099
    | Mm_RefseqmRNA = XM_001000715
    | Mm_RefseqProtein = XP_001000715
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 74980763
    | Mm_GenLoc_end = 74985714
    | Mm_Uniprot = Q5NCQ8
  }}
}}
'''Hypermethylated in cancer 1''', also known as '''HIC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIC1 hypermethylated in cancer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3090| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chopin V, Leprince D |title=[Chromosome arm 17p13.3: could HIC1 be the one ?] |journal=Med Sci (Paris) |volume=22 |issue= 1 |pages= 54-61 |year= 2006 |pmid= 16386221 |doi=  }}
*{{cite journal  |vauthors=Chopin V, Leprince D |title=[Chromosome arm 17p13.3: could HIC1 be the one ?] |journal=Med Sci (Paris) |volume=22 |issue= 1 |pages= 54–61 |year= 2006 |pmid= 16386221 |doi=10.1051/medsci/200622154 }}
*{{cite journal | author=Wales MM, Biel MA, el Deiry W, ''et al.'' |title=p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. |journal=Nat. Med. |volume=1 |issue= 6 |pages= 570-7 |year= 1995 |pmid= 7585125 |doi=  }}
*{{cite journal   |vauthors=Wales MM, Biel MA, el Deiry W, etal |title=p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. |journal=Nat. Med. |volume=1 |issue= 6 |pages= 570–7 |year= 1995 |pmid= 7585125 |doi=10.1038/nm0695-570 }}
*{{cite journal | author=Fujii H, Biel MA, Zhou W, ''et al.'' |title=Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. |journal=Oncogene |volume=16 |issue= 16 |pages= 2159-64 |year= 1998 |pmid= 9572497 |doi= 10.1038/sj.onc.1201976 }}
*{{cite journal   |vauthors=Fujii H, Biel MA, Zhou W, etal |title=Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. |journal=Oncogene |volume=16 |issue= 16 |pages= 2159–64 |year= 1998 |pmid= 9572497 |doi= 10.1038/sj.onc.1201976 }}
*{{cite journal  | author=Deltour S, Guerardel C, Stehelin D, Leprince D |title=The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved. |journal=Biochim. Biophys. Acta |volume=1443 |issue= 1-2 |pages= 230-2 |year= 1999 |pmid= 9838134 |doi=  }}
*{{cite journal  |vauthors=Deltour S, Guerardel C, Stehelin D, Leprince D |title=The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved. |journal=Biochim. Biophys. Acta |volume=1443 |issue= 1-2 |pages= 230–2 |year= 1999 |pmid= 9838134 |doi=  10.1016/s0167-4781(98)00219-x}}
*{{cite journal  | author=Deltour S, Guerardel C, Leprince D |title=Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 26 |pages= 14831-6 |year= 2000 |pmid= 10611298 |doi=  }}
*{{cite journal  |vauthors=Deltour S, Guerardel C, Leprince D |title=Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 26 |pages= 14831–6 |year= 2000 |pmid= 10611298 |doi=10.1073/pnas.96.26.14831  | pmc=24733 }}
*{{cite journal | author=Guerardel C, Deltour S, Pinte S, ''et al.'' |title=Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 3078-89 |year= 2001 |pmid= 11073960 |doi= 10.1074/jbc.M008690200 }}
*{{cite journal   |vauthors=Guerardel C, Deltour S, Pinte S, etal |title=Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 3078–89 |year= 2001 |pmid= 11073960 |doi= 10.1074/jbc.M008690200 }}
*{{cite journal  | author=Deltour S, Pinte S, Guérardel C, Leprince D |title=Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 2 |pages= 427-34 |year= 2001 |pmid= 11554746 |doi= 10.1006/bbrc.2001.5624 }}
*{{cite journal  |vauthors=Deltour S, Pinte S, Guérardel C, Leprince D |title=Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 2 |pages= 427–34 |year= 2001 |pmid= 11554746 |doi= 10.1006/bbrc.2001.5624 }}
*{{cite journal | author=Deltour S, Pinte S, Guerardel C, ''et al.'' |title=The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4890-901 |year= 2002 |pmid= 12052894 |doi=  }}
*{{cite journal   |vauthors=Deltour S, Pinte S, Guerardel C, etal |title=The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4890–901 |year= 2002 |pmid= 12052894 |doi=10.1128/MCB.22.13.4890-4901.2002  | pmc=133903 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Cardoso C, Leventer RJ, Ward HL, ''et al.'' |title=Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 918-30 |year= 2003 |pmid= 12621583 |doi=  }}
*{{cite journal   |vauthors=Cardoso C, Leventer RJ, Ward HL, etal |title=Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 918–30 |year= 2003 |pmid= 12621583 |doi=10.1086/374320  | pmc=1180354 }}
*{{cite journal | author=Rathi A, Virmani AK, Harada K, ''et al.'' |title=Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms. |journal=Clin. Cancer Res. |volume=9 |issue= 10 Pt 1 |pages= 3674-8 |year= 2004 |pmid= 14506157 |doi=  }}
*{{cite journal   |vauthors=Rathi A, Virmani AK, Harada K, etal |title=Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms. |journal=Clin. Cancer Res. |volume=9 |issue= 10 Pt 1 |pages= 3674–8 |year= 2004 |pmid= 14506157 |doi=  }}
*{{cite journal | author=Waha A, Waha A, Koch A, ''et al.'' |title=Epigenetic silencing of the HIC-1 gene in human medulloblastomas. |journal=J. Neuropathol. Exp. Neurol. |volume=62 |issue= 11 |pages= 1192-201 |year= 2004 |pmid= 14656076 |doi=  }}
*{{cite journal   |vauthors=Waha A, Waha A, Koch A, etal |title=Epigenetic silencing of the HIC-1 gene in human medulloblastomas. |journal=J. Neuropathol. Exp. Neurol. |volume=62 |issue= 11 |pages= 1192–201 |year= 2004 |pmid= 14656076 |doi=  }}
*{{cite journal | author=Lindsey JC, Lusher ME, Anderton JA, ''et al.'' |title=Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. |journal=Carcinogenesis |volume=25 |issue= 5 |pages= 661-8 |year= 2004 |pmid= 14688019 |doi= 10.1093/carcin/bgh055 }}
*{{cite journal   |vauthors=Lindsey JC, Lusher ME, Anderton JA, etal |title=Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. |journal=Carcinogenesis |volume=25 |issue= 5 |pages= 661–8 |year= 2004 |pmid= 14688019 |doi= 10.1093/carcin/bgh055 }}
*{{cite journal | author=Pinte S, Guérardel C, Deltour-Balerdi S, ''et al.'' |title=Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1. |journal=Oncogene |volume=23 |issue= 22 |pages= 4023-31 |year= 2004 |pmid= 15007385 |doi= 10.1038/sj.onc.1207504 }}
*{{cite journal   |vauthors=Pinte S, Guérardel C, Deltour-Balerdi S, etal |title=Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1. |journal=Oncogene |volume=23 |issue= 22 |pages= 4023–31 |year= 2004 |pmid= 15007385 |doi= 10.1038/sj.onc.1207504 }}
*{{cite journal | author=Pinte S, Stankovic-Valentin N, Deltour S, ''et al.'' |title=The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38313-24 |year= 2004 |pmid= 15231840 |doi= 10.1074/jbc.M401610200 }}
*{{cite journal   |vauthors=Pinte S, Stankovic-Valentin N, Deltour S, etal |title=The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38313–24 |year= 2004 |pmid= 15231840 |doi= 10.1074/jbc.M401610200 }}
*{{cite journal | author=Chen W, Cooper TK, Zahnow CA, ''et al.'' |title=Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. |journal=Cancer Cell |volume=6 |issue= 4 |pages= 387-98 |year= 2004 |pmid= 15488761 |doi= 10.1016/j.ccr.2004.08.030 }}
*{{cite journal   |vauthors=Chen W, Cooper TK, Zahnow CA, etal |title=Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. |journal=Cancer Cell |volume=6 |issue= 4 |pages= 387–98 |year= 2004 |pmid= 15488761 |doi= 10.1016/j.ccr.2004.08.030 }}
*{{cite journal | author=Britschgi C, Rizzi M, Grob TJ, ''et al.'' |title=Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1. |journal=Oncogene |volume=25 |issue= 14 |pages= 2030-9 |year= 2006 |pmid= 16301995 |doi= 10.1038/sj.onc.1209240 }}
*{{cite journal   |vauthors=Britschgi C, Rizzi M, Grob TJ, etal |title=Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1. |journal=Oncogene |volume=25 |issue= 14 |pages= 2030–9 |year= 2006 |pmid= 16301995 |doi= 10.1038/sj.onc.1209240 }}
*{{cite journal | author=Valenta T, Lukas J, Doubravska L, ''et al.'' |title=HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. |journal=EMBO J. |volume=25 |issue= 11 |pages= 2326-37 |year= 2006 |pmid= 16724116 |doi= 10.1038/sj.emboj.7601147 }}
*{{cite journal   |vauthors=Valenta T, Lukas J, Doubravska L, etal |title=HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. |journal=EMBO J. |volume=25 |issue= 11 |pages= 2326–37 |year= 2006 |pmid= 16724116 |doi= 10.1038/sj.emboj.7601147 | pmc=1478201 }}
*{{cite journal | author=Stankovic-Valentin N, Verger A, Deltour-Balerdi S, ''et al.'' |title=A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. |journal=FEBS J. |volume=273 |issue= 13 |pages= 2879-90 |year= 2006 |pmid= 16762039 |doi= 10.1111/j.1742-4658.2006.05301.x }}
*{{cite journal   |vauthors=Stankovic-Valentin N, Verger A, Deltour-Balerdi S, etal |title=A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. |journal=FEBS J. |volume=273 |issue= 13 |pages= 2879–90 |year= 2006 |pmid= 16762039 |doi= 10.1111/j.1742-4658.2006.05301.x }}
}}
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* {{MeshName|HIC1+protein,+human}}
* {{MeshName|HIC1+protein,+human}}


{{NLM content}}
{{Transcription factors|g2}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]
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{{gene-17-stub}}

Latest revision as of 13:35, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.[1]


References

  1. ↑ "Entrez Gene: HIC1 hypermethylated in cancer 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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