HAND1

Heart and neural crest derivatives expressed 1
Identifiers
Symbols	HAND1 ; Hxt; Thing1; eHand
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3545
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Heart and neural crest derivatives expressed 1, also known as HAND1, is a human gene.

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.

Further reading

• Srivastava D (1999). "HAND proteins: molecular mediators of cardiac development and congenital heart disease". Trends Cardiovasc. Med. 9 (1–2): 11–8. PMID 10189962.
• Weber MC, de Clarke V, Harwin RM, Shiff CJ (1976). "An extended field trial of pyrimethamine combined with dapsone in the prophylaxis of malaria". The Central African journal of medicine. 21 (9): 187–92. PMID 1182795.CS1 maint: Multiple names: authors list (link)
• Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.CS1 maint: Multiple names: authors list (link)
• Russell MW, Baker P, Izumo S (1998). "Cloning, chromosomal mapping, and expression of the human eHAND gene". Mamm. Genome. 8 (11): 863–5. PMID 9337404.CS1 maint: Multiple names: authors list (link)
• Knöfler M, Meinhardt G, Vasicek R; et al. (1999). "Molecular cloning of the human Hand1 gene/cDNA and its tissue-restricted expression in cytotrophoblastic cells and heart". Gene. 224 (1–2): 77–86. PMID 9931445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scott IC, Anson-Cartwright L, Riley P; et al. (2000). "The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms". Mol. Cell. Biol. 20 (2): 530–41. PMID 10611232.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bounpheng MA, Morrish TA, Dodds SG, Christy BA (2000). "Negative regulation of selected bHLH proteins by eHAND". Exp. Cell Res. 257 (2): 320–31. doi:10.1006/excr.2000.4898. PMID 10837146.CS1 maint: Multiple names: authors list (link)
• Firulli BA, Hadzic DB, McDaid JR, Firulli AB (2000). "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function". J. Biol. Chem. 275 (43): 33567–73. doi:10.1074/jbc.M005888200. PMID 10924525.CS1 maint: Multiple names: authors list (link)
• Knöfler M, Meinhardt G, Bauer S; et al. (2002). "Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains". Biochem. J. 361 (Pt 3): 641–51. PMID 11802795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dai YS, Cserjesi P (2002). "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer". J. Biol. Chem. 277 (15): 12604–12. doi:10.1074/jbc.M200283200. PMID 11812799.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srivastava D, Gottlieb PD, Olson EN (2003). "Molecular mechanisms of ventricular hypoplasia". Cold Spring Harb. Symp. Quant. Biol. 67: 121–5. PMID 12858532.CS1 maint: Multiple names: authors list (link)
• Firulli BA, Howard MJ, McDaid JR; et al. (2004). "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation". Mol. Cell. 12 (5): 1225–37. PMID 14636580.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hill AA, Riley PR (2004). "Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2". Mol. Cell. Biol. 24 (22): 9835–47. doi:10.1128/MCB.24.22.9835-9847.2004. PMID 15509787.
• Morin S, Pozzulo G, Robitaille L; et al. (2005). "MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters". J. Biol. Chem. 280 (37): 32272–8. doi:10.1074/jbc.M507640200. PMID 16043483.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HAND1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.