GTF3C1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''General transcription factor 3C polypeptide 1''' is a [[protein]] that in humans is encoded by the ''GTF3C1'' [[gene]].<ref name="pmid8164661">{{cite journal | vauthors = Lagna G, Kovelman R, Sukegawa J, Roeder RG | title = Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC | journal = Mol. Cell. Biol. | volume = 14 | issue = 5 | pages = 3053–64  | date = May 1994 | pmid = 8164661 | pmc = 358673 | doi =  10.1128/mcb.14.5.3053}}</ref><ref name="pmid8127861">{{cite journal | vauthors = L'Etoile ND, Fahnestock ML, Shen Y, Aebersold R, Berk AJ | title = Human transcription factor IIIC box B binding subunit | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 5 | pages = 1652–6  | date = Apr 1994 | pmid = 8127861 | pmc = 43221 | doi = 10.1073/pnas.91.5.1652 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2975| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = General transcription factor IIIC, polypeptide 1, alpha 220kDa
| HGNCid = 4664
| Symbol = GTF3C1
| AltSymbols =; DKFZp686A111; TFIIIC; TFIIIC220; TFIIICalpha
| OMIM = 603246
| ECnumber = 
| Homologene = 31040
| MGIid = 107887
| GeneAtlas_image1 = PBB_GE_GTF3C1_35671_at_tn.png
| GeneAtlas_image2 = PBB_GE_GTF3C1_202320_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003709 |text = RNA polymerase III transcription factor activity}}
| Component = {{GNF_GO|id=GO:0000127 |text = transcription factor TFIIIC complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006383 |text = transcription from RNA polymerase III promoter}} {{GNF_GO|id=GO:0009303 |text = rRNA transcription}} {{GNF_GO|id=GO:0009304 |text = tRNA transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2975
    | Hs_Ensembl = ENSG00000077235
    | Hs_RefseqProtein = NP_001511
    | Hs_RefseqmRNA = NM_001520
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 27379436
    | Hs_GenLoc_end = 27468735
    | Hs_Uniprot = Q12789
    | Mm_EntrezGene = 233863
    | Mm_Ensembl = ENSMUSG00000032777
    | Mm_RefseqmRNA = NM_207239
    | Mm_RefseqProtein = NP_997122
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 125432102
    | Mm_GenLoc_end = 125498836
    | Mm_Uniprot = A0JLN7
  }}
}}
'''General transcription factor IIIC, polypeptide 1, alpha 220kDa''', also known as '''GTF3C1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2975| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
GTF3C1 has been shown to [[Protein-protein interaction|interact]] with [[GTF3C4]].<ref name=pmid10523658>{{cite journal | vauthors = Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG | title = The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity | journal = Mol. Cell. Biol. | volume = 19 | issue = 11 | pages = 7697–704  | date = Nov 1999 | pmid = 10523658 | pmc = 84812 | doi=10.1128/mcb.19.11.7697}}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Jang KL, Collins MK, Latchman DS | title = The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC | journal = J. Acquir. Immune Defic. Syndr. | volume = 5 | issue = 11 | pages = 1142–7 | year = 1992 | pmid = 1403646 | doi =  }}
| citations =
* {{cite journal | vauthors = Kovelman R, Roeder RG | title = Purification and characterization of two forms of human transcription factor IIIC | journal = J. Biol. Chem. | volume = 267 | issue = 34 | pages = 24446–56 | year = 1992 | pmid = 1447193 | doi =  }}
*{{cite journal | author=Jang KL, Collins MK, Latchman DS |title=The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC. |journal=J. Acquir. Immune Defic. Syndr. |volume=5 |issue= 11 |pages= 1142-7 |year= 1992 |pmid= 1403646 |doi=  }}
* {{cite journal | vauthors = Wang Z, Roeder RG | title = DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III | journal = Mol. Cell | volume = 1 | issue = 5 | pages = 749–57 | year = 1998 | pmid = 9660958 | doi = 10.1016/S1097-2765(00)80074-X }}
*{{cite journal | author=Kovelman R, Roeder RG |title=Purification and characterization of two forms of human transcription factor IIIC. |journal=J. Biol. Chem. |volume=267 |issue= 34 |pages= 24446-56 |year= 1992 |pmid= 1447193 |doi=  }}
* {{cite journal | vauthors = Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD | title = Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q | journal = Genomics | volume = 60 | issue = 3 | pages = 295–308 | year = 1999 | pmid = 10493829 | doi = 10.1006/geno.1999.5927 }}
*{{cite journal | author=L'Etoile ND, Fahnestock ML, Shen Y, ''et al.'' |title=Human transcription factor IIIC box B binding subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 5 |pages= 1652-6 |year= 1994 |pmid= 8127861 |doi=  }}
* {{cite journal | vauthors = Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG | title = The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity | journal = Mol. Cell. Biol. | volume = 19 | issue = 11 | pages = 7697–704 | year = 1999 | pmid = 10523658 | pmc = 84812 | doi =  10.1128/mcb.19.11.7697}}
*{{cite journal  | author=Lagna G, Kovelman R, Sukegawa J, Roeder RG |title=Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC. |journal=Mol. Cell. Biol. |volume=14 |issue= 5 |pages= 3053-64 |year= 1994 |pmid= 8164661 |doi=  }}
* {{cite journal | vauthors = Meissner W, Thomae R, Seifart KH | title = The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7148–56 | year = 2002 | pmid = 11741993 | doi = 10.1074/jbc.M108721200 }}
*{{cite journal  | author=Wang Z, Roeder RG |title=DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III. |journal=Mol. Cell |volume=1 |issue= 5 |pages= 749-57 |year= 1998 |pmid= 9660958 |doi= }}
* {{cite journal | vauthors = Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES | title = Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC | journal = Cell Death Differ. | volume = 9 | issue = 4 | pages = 439–47 | year = 2002 | pmid = 11965497 | doi = 10.1038/sj/cdd/4401038 }}
*{{cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295-308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
* {{cite journal | vauthors = Weser S, Riemann J, Seifart KH, Meissner W | title = Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene | journal = Nucleic Acids Res. | volume = 31 | issue = 9 | pages = 2408–16 | year = 2003 | pmid = 12711686 | pmc = 154231 | doi = 10.1093/nar/gkg345 }}
*{{cite journal | author=Hsieh YJ, Kundu TK, Wang Z, ''et al.'' |title=The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7697-704 |year= 1999 |pmid= 10523658 |doi=  }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Meissner W, Thomae R, Seifart KH |title=The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7148-56 |year= 2002 |pmid= 11741993 |doi= 10.1074/jbc.M108721200 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Zhan Y, Hegde R, Srinivasula SM, ''et al.'' |title=Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. |journal=Cell Death Differ. |volume=9 |issue= 4 |pages= 439-47 |year= 2002 |pmid= 11965497 |doi= 10.1038/sj/cdd/4401038 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M | title = Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC | journal = J. Biol. Chem. | volume = 282 | issue = 23 | pages = 17179–89 | year = 2007 | pmid = 17409385 | doi = 10.1074/jbc.M611542200 }}
*{{cite journal  | author=Weser S, Riemann J, Seifart KH, Meissner W |title=Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene. |journal=Nucleic Acids Res. |volume=31 |issue= 9 |pages= 2408-16 |year= 2003 |pmid= 12711686 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Dumay-Odelot H, Marck C, Durrieu-Gaillard S, ''et al.'' |title=Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. |journal=J. Biol. Chem. |volume=282 |issue= 23 |pages= 17179-89 |year= 2007 |pmid= 17409385 |doi= 10.1074/jbc.M611542200 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|GTF3C1+protein,+human}}
* {{MeshName|GTF3C1+protein,+human}}


{{NLM content}}
{{Transcription factors|g2}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-16-stub}}

Revision as of 02:16, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

General transcription factor 3C polypeptide 1 is a protein that in humans is encoded by the GTF3C1 gene.[1][2][3]

Interactions

GTF3C1 has been shown to interact with GTF3C4.[4]

References

  1. ↑ Lagna G, Kovelman R, Sukegawa J, Roeder RG (May 1994). "Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC". Mol. Cell. Biol. 14 (5): 3053–64. doi:10.1128/mcb.14.5.3053. PMC 358673. PMID 8164661.
  2. ↑ L'Etoile ND, Fahnestock ML, Shen Y, Aebersold R, Berk AJ (Apr 1994). "Human transcription factor IIIC box B binding subunit". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1652–6. doi:10.1073/pnas.91.5.1652. PMC 43221. PMID 8127861.
  3. ↑ "Entrez Gene: GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa".
  4. ↑ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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