GTF2H4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''General transcription factor IIH subunit 4''' is a [[protein]] that in humans is encoded by the ''GTF2H4'' [[gene]].<ref name="pmid9118947">{{cite journal | vauthors = Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM | title = Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH | journal = EMBO J. | volume = 16 | issue = 5 | pages = 1093–102  | date = Apr 1997 | pmid = 9118947 | pmc = 1169708 | doi = 10.1093/emboj/16.5.1093 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2968| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = General transcription factor IIH, polypeptide 4, 52kDa
| HGNCid = 4658
| Symbol = GTF2H4
| AltSymbols =; TFIIH
| OMIM = 601760
| ECnumber = 
| Homologene = 7090
| MGIid = 1338799
| GeneAtlas_image1 = PBB_GE_GTF2H4_203577_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005675 |text = holo TFIIH complex}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2968
    | Hs_Ensembl = ENSG00000137411
    | Hs_RefseqProtein = NP_001508
    | Hs_RefseqmRNA = NM_001517
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 30983997
    | Hs_GenLoc_end = 31002215
    | Hs_Uniprot = Q92759
    | Mm_EntrezGene = 14885
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_010364
    | Mm_RefseqProtein = NP_034494
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''General transcription factor IIH, polypeptide 4, 52kDa''', also known as '''GTF2H4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2968| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
GTF2H4 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[GTF2F1]],<ref name = pmid9159119/>
| section_title =  
* [[MED21]],<ref name = pmid9159119>{{cite journal | vauthors = Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD | title = BRCA1 is a component of the RNA polymerase II holoenzyme | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 11 | pages = 5605–10  | date = May 1997 | pmid = 9159119 | pmc = 20825 | doi = 10.1073/pnas.94.11.5605}}</ref>
| summary_text =  
* [[POLR2A]],<ref name = pmid9159119/>
}}
* [[TATA binding protein]],<ref name = pmid9159119/>
* [[Transcription Factor II B]],<ref name = pmid9159119/> and
* [[XPB]].<ref name = pmid9118947 /><ref name = pmid15220921>{{cite journal | vauthors = Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W | title = A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A | journal = Nat. Genet. | volume = 36 | issue = 7 | pages = 714–9  | date = Jul 2004 | pmid = 15220921 | doi = 10.1038/ng1387 }}</ref>


==See also==
== See also ==
* [[Transcription Factor II H]]
* [[Transcription Factor II H]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Jeang KT | title = Tat, Tat-associated kinase, and transcription | journal = J. Biomed. Sci. | volume = 5 | issue = 1 | pages = 24–7 | year = 1998 | pmid = 9570510 | doi = 10.1007/BF02253352 }}
| citations =
* {{cite journal | vauthors = Yankulov K, Bentley D | title = Transcriptional control: Tat cofactors and transcriptional elongation | journal = Curr. Biol. | volume = 8 | issue = 13 | pages = R447-9 | year = 1998 | pmid = 9651670 | doi = 10.1016/S0960-9822(98)70289-1 }}
*{{cite journal | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24-7 |year= 1998 |pmid= 9570510 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447-9 |year= 1998 |pmid= 9651670 |doi= }}
* {{cite journal | vauthors = Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D | title = Three functional classes of transcriptional activation domain | journal = Mol. Cell. Biol. | volume = 16 | issue = 5 | pages = 2044–55 | year = 1996 | pmid = 8628270 | pmc = 231191 | doi =  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D | title = Human cyclin-dependent kinase-activating kinase exists in three distinct complexes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 13 | pages = 6488–93 | year = 1996 | pmid = 8692842 | pmc = 39050 | doi = 10.1073/pnas.93.13.6488 }}
*{{cite journal | author=Blau J, Xiao H, McCracken S, ''et al.'' |title=Three functional classes of transcriptional activation domain. |journal=Mol. Cell. Biol. |volume=16 |issue= 5 |pages= 2044-55 |year= 1996 |pmid= 8628270 |doi=  }}
* {{cite journal | vauthors = Zhou Q, Sharp PA | title = Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat | journal = Science | volume = 274 | issue = 5287 | pages = 605–10 | year = 1996 | pmid = 8849451 | doi = 10.1126/science.274.5287.605 }}
*{{cite journal | author=Drapkin R, Le Roy G, Cho H, ''et al.'' |title=Human cyclin-dependent kinase-activating kinase exists in three distinct complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6488-93 |year= 1996 |pmid= 8692842 |doi= }}
* {{cite journal | vauthors = Parada CA, Roeder RG | title = Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain | journal = Nature | volume = 384 | issue = 6607 | pages = 375–8 | year = 1996 | pmid = 8934526 | doi = 10.1038/384375a0 }}
*{{cite journal | author=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. |journal=Science |volume=274 |issue= 5287 |pages= 605-10 |year= 1996 |pmid= 8849451 |doi= }}
* {{cite journal | vauthors = García-Martínez LF, Ivanov D, Gaynor RB | title = Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes | journal = J. Biol. Chem. | volume = 272 | issue = 11 | pages = 6951–8 | year = 1997 | pmid = 9054383 | doi = 10.1074/jbc.272.11.6951 }}
*{{cite journal | author=Parada CA, Roeder RG |title=Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. |journal=Nature |volume=384 |issue= 6607 |pages= 375-8 |year= 1996 |pmid= 8934526 |doi= 10.1038/384375a0 }}
* {{cite journal | vauthors = Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM | title = The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 1817–23 | year = 1997 | pmid = 9121429 | pmc = 232028 | doi =  }}
*{{cite journal | author=García-Martínez LF, Ivanov D, Gaynor RB |title=Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes. |journal=J. Biol. Chem. |volume=272 |issue= 11 |pages= 6951-8 |year= 1997 |pmid= 9054383 |doi= }}
* {{cite journal | vauthors = Rossignol M, Kolb-Cheynel I, Egly JM | title = Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH | journal = EMBO J. | volume = 16 | issue = 7 | pages = 1628–37 | year = 1997 | pmid = 9130708 | pmc = 1169767 | doi = 10.1093/emboj/16.7.1628 }}
*{{cite journal  | author=Marinoni JC, Roy R, Vermeulen W, ''et al.'' |title=Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. |journal=EMBO J. |volume=16 |issue= 5 |pages= 1093-102 |year= 1997 |pmid= 9118947 |doi= 10.1093/emboj/16.5.1093 }}
* {{cite journal | vauthors = Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD | title = BRCA1 is a component of the RNA polymerase II holoenzyme | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 11 | pages = 5605–10 | year = 1997 | pmid = 9159119 | pmc = 20825 | doi = 10.1073/pnas.94.11.5605 }}
*{{cite journal | author=Cujec TP, Cho H, Maldonado E, ''et al.'' |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817-23 |year= 1997 |pmid= 9121429 |doi=  }}
* {{cite journal | vauthors = García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB | title = Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription | journal = EMBO J. | volume = 16 | issue = 10 | pages = 2836–50 | year = 1997 | pmid = 9184228 | pmc = 1169892 | doi = 10.1093/emboj/16.10.2836 }}
*{{cite journal | author=Rossignol M, Kolb-Cheynel I, Egly JM |title=Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH. |journal=EMBO J. |volume=16 |issue= 7 |pages= 1628-37 |year= 1997 |pmid= 9130708 |doi= 10.1093/emboj/16.7.1628 }}
* {{cite journal | vauthors = Nekhai S, Shukla RR, Kumar A | title = A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity | journal = J. Virol. | volume = 71 | issue = 10 | pages = 7436–41 | year = 1997 | pmid = 9311822 | pmc = 192089 | doi =  }}
*{{cite journal | author=Scully R, Anderson SF, Chao DM, ''et al.'' |title=BRCA1 is a component of the RNA polymerase II holoenzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5605-10 |year= 1997 |pmid= 9159119 |doi= }}
* {{cite journal | vauthors = Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM | title = The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II | journal = Genes Dev. | volume = 11 | issue = 20 | pages = 2645–57 | year = 1997 | pmid = 9334327 | pmc = 316603 | doi = 10.1101/gad.11.20.2645 }}
*{{cite journal | author=García-Martínez LF, Mavankal G, Neveu JM, ''et al.'' |title=Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. |journal=EMBO J. |volume=16 |issue= 10 |pages= 2836-50 |year= 1997 |pmid= 9184228 |doi= 10.1093/emboj/16.10.2836 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Nekhai S, Shukla RR, Kumar A |title=A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity. |journal=J. Virol. |volume=71 |issue= 10 |pages= 7436-41 |year= 1997 |pmid= 9311822 |doi=  }}
* {{cite journal | vauthors = Li XY, Green MR | title = The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor | journal = Genes Dev. | volume = 12 | issue = 19 | pages = 2992–6 | year = 1998 | pmid = 9765201 | pmc = 317190 | doi = 10.1101/gad.12.19.2992 }}
*{{cite journal | author=Cujec TP, Okamoto H, Fujinaga K, ''et al.'' |title=The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. |journal=Genes Dev. |volume=11 |issue= 20 |pages= 2645-57 |year= 1997 |pmid= 9334327 |doi= }}
* {{cite journal | vauthors = Ping YH, Rana TM | title = Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes | journal = J. Biol. Chem. | volume = 274 | issue = 11 | pages = 7399–404 | year = 1999 | pmid = 10066804 | doi = 10.1074/jbc.274.11.7399 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Li XY, Green MR |title=The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor. |journal=Genes Dev. |volume=12 |issue= 19 |pages= 2992-6 |year= 1998 |pmid= 9765201 |doi= }}
*{{cite journal | author=Ping YH, Rana TM |title=Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes. |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 7399-404 |year= 1999 |pmid= 10066804 |doi= }}
}}
{{refend}}
{{refend}}


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* {{MeshName|GTF2H4+protein,+human}}
* {{MeshName|GTF2H4+protein,+human}}


{{Transcription factors|g2}}


{{protein-stub}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-6-stub}}

Latest revision as of 09:08, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.[1][2]

Interactions

GTF2H4 has been shown to interact with:

See also

References

  1. ↑ 1.0 1.1 Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (Apr 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947.
  2. ↑ "Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa".
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
  4. ↑ Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. doi:10.1038/ng1387. PMID 15220921.

Further reading

External links


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