FHL3: Difference between revisions

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Latest revision as of 19:55, 8 November 2017

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.^[1]^[2]^[3]

LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.[supplied by OMIM]^[3]

Interactions

FHL3 has been shown to interact with:

References

↑ Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem Biophys Res Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811.
↑ Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1". Somat Cell Mol Genet. 24 (3): 197–202. doi:10.1023/B:SCAM.0000007122.03392.4b. PMID 10226657.
↑ ^3.0 ^3.1 "Entrez Gene: FHL3 four and a half LIM domains 3".
↑ ^4.0 ^4.1 Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/mcb.20.22.8613-8622.2000. PMC 102166. PMID 11046156.
↑ ^5.0 ^5.1 Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (April 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
↑ Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM (2001). "Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. PMID 11135358.
↑ Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962.

Morgan MJ, Madgwick AJ (1999). "The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle". Biochem. Biophys. Res. Commun. 255 (2): 245–50. doi:10.1006/bbrc.1999.0179. PMID 10049693.
Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM (2001). "Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. PMID 11135358.
Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
Mils V, Lee SM, Joly W, Hang EW, Baldin V, Waye MM, Ducommun B, Tsui SK (2003). "LIM-only protein FHL3 interacts with CDC25B2 phosphatase". Exp. Cell Res. 285 (1): 99–106. doi:10.1016/S0014-4827(03)00018-1. PMID 12681290.
Coghill ID, Brown S, Cottle DL, McGrath MJ, Robinson PA, Nandurkar HH, Dyson JM, Mitchell CA (2003). "FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly". J. Biol. Chem. 278 (26): 24139–52. doi:10.1074/jbc.M213259200. PMID 12704194.
Purcell NH, Darwis D, Bueno OF, Müller JM, Schüle R, Molkentin JD (2004). "Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes". Mol. Cell. Biol. 24 (3): 1081–95. doi:10.1128/MCB.24.3.1081-1095.2004. PMC 321437. PMID 14729955.
Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V (2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962.
Takahashi K, Matsumoto C, Ra C (2005). "FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1". Biochem. J. 386 (Pt 1): 191–200. doi:10.1042/BJ20040775. PMC 1134781. PMID 15453830.
Philippar U, Schratt G, Dieterich C, Müller JM, Galgóczy P, Engel FB, Keating MT, Gertler F, Schüle R, Vingron M, Nordheim A (2005). "The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF". Mol. Cell. 16 (6): 867–80. doi:10.1016/j.molcel.2004.11.039. PMID 15610731.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Cottle DL, McGrath MJ, Cowling BS, Coghill ID, Brown S, Mitchell CA (2007). "FHL3 binds MyoD and negatively regulates myotube formation". J. Cell Sci. 120 (Pt 8): 1423–35. doi:10.1242/jcs.004739. PMID 17389685.

External links

FHL3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid8753811-1] Morgan MJ, Madgwick AJ (October 1996). "Slim defines a novel family of LIM-proteins expressed in skeletal muscle". Biochem Biophys Res Commun. 225 (2): 632–8. doi:10.1006/bbrc.1996.1222. PMID 8753811.

[pmid10226657-2] Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999). "Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1". Somat Cell Mol Genet. 24 (3): 197–202. doi:10.1023/B:SCAM.0000007122.03392.4b. PMID 10226657.

[entrez-3] 3.0 ^3.1 "Entrez Gene: FHL3 four and a half LIM domains 3".

[pmid11046156-4] 4.0 ^4.1 Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/mcb.20.22.8613-8622.2000. PMC 102166. PMID 11046156.

[pmid12556451-5] 5.0 ^5.1 Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (April 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.

[pmid11135358-6] Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM (2001). "Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)". J. Cell. Biochem. 80 (3): 293–303. doi:10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U. PMID 11135358.

[pmid15117962-7] Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V (July 2004). "The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641–52. doi:10.1074/jbc.M312894200. PMID 15117962.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Use dmy dates|date=April 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Four and a half LIM domains protein 3''' is a [[protein]] that in humans is encoded by the ''FHL3'' [[gene]].<ref name="pmid8753811">{{cite journal | vauthors = Morgan MJ, Madgwick AJ | title = Slim defines a novel family of LIM-proteins expressed in skeletal muscle | journal = Biochem Biophys Res Commun | volume = 225 | issue = 2 | pages = 632–8 | date = October 1996 | pmid = 8753811 | pmc =  | doi = 10.1006/bbrc.1996.1222 }}</ref><ref name="pmid10226657">{{cite journal | vauthors = Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY | title = Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1 | journal = Somat Cell Mol Genet | volume = 24 | issue = 3 | pages = 197–202 | date = May 1999 | pmid = 10226657 | pmc =  | doi = 10.1023/B:SCAM.0000007122.03392.4b }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FHL3 four and a half LIM domains 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2275| accessdate = }}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+LIM proteins are defined by the possession of a highly conserved double [[zinc finger]] motif called the [[LIM domain]].[supplied by OMIM]<ref name="entrez"/>
-{{GNF_Protein_box
- | image = PBB_Protein_FHL3_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wyh.
- | PDB = {{PDB2|1wyh}}, {{PDB2|2cuq}}
- | Name = Four and a half LIM domains 3
- | HGNCid = 3704
- | Symbol = FHL3
- | AltSymbols =; MGC19547; MGC23614; MGC8696; SLIM2
- | OMIM = 602790
- | ECnumber =
- | Homologene = 37928
- | MGIid = 1341092
- | GeneAtlas_image1 = PBB_GE_FHL3_218818_at_tn.png
- | Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0001725 |text = stress fiber}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030018 |text = Z disc}}
- | Process = {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 2275
-    | Hs_Ensembl = ENSG00000183386
-    | Hs_RefseqProtein = NP_004459
-    | Hs_RefseqmRNA = NM_004468
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 38235025
-    | Hs_GenLoc_end = 38243830
-    | Hs_Uniprot = Q13643
-    | Mm_EntrezGene = 14201
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA = XM_906783
-    | Mm_RefseqProtein = XP_911876
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Four and a half LIM domains 3''', also known as '''FHL3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FHL3 four and a half LIM domains 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2275| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{PBB_Summary
-| section_title =
-| summary_text = LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: FHL3 four and a half LIM domains 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2275| accessdate = }}</ref>
-}}
-==References==
+FHL3 has been shown to [[Protein–protein interaction|interact]] with:
-{{reflist|2}}
+* [[CREB1]],<ref name = pmid11046156/>
-==Further reading==
+* [[CTBP2]],<ref name = pmid12556451>{{cite journal | vauthors = Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M | title = The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2 | journal = J. Biol. Chem. | volume = 278 | issue = 15 | pages = 12786–95 | date = April 2003 | pmid = 12556451 | doi = 10.1074/jbc.M300587200 }}</ref>
+* [[FHL2]],<ref name = pmid11046156>{{cite journal | vauthors = Fimia GM, De Cesare D, Sassone-Corsi P | title = A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM | journal = Mol. Cell. Biol. | volume = 20 | issue = 22 | pages = 8613–22 | date = November 2000 | pmid = 11046156 | pmc = 102166 | doi =  10.1128/mcb.20.22.8613-8622.2000}}</ref><ref name = pmid11135358>{{cite journal | vauthors = Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM | title = Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET) | journal = J. Cell. Biochem. | volume = 80 | issue = 3 | pages = 293–303 | pmid = 11135358 | doi = 10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U | year=2001}}</ref>
+* [[ITGA7]]<ref name = pmid15117962>{{cite journal | vauthors = Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V | title = The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor | journal = J. Biol. Chem. | volume = 279 | issue = 27 | pages = 28641–52 | date = July 2004 | pmid = 15117962 | doi = 10.1074/jbc.M312894200 }}</ref> and
+* [[KLF3]].<ref name = pmid12556451/>
+== References ==
+{{reflist}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Morgan MJ, Madgwick AJ | title = The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. | journal = Biochem. Biophys. Res. Commun. | volume = 255 | issue = 2 | pages = 245–50 | year = 1999 | pmid = 10049693 | doi = 10.1006/bbrc.1999.0179 }}
-| citations =
+* {{cite journal | vauthors = Li HY, Ng EK, Lee SM, Kotaka M, Tsui SK, Lee CY, Fung KP, Waye MM | title = Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET). | journal = J. Cell. Biochem. | volume = 80 | issue = 3 | pages = 293–303 | year = 2001 | pmid = 11135358 | doi = 10.1002/1097-4644(20010301)80:3<293::AID-JCB10>3.0.CO;2-U }}
-*{{cite journal  | author=Morgan MJ, Madgwick AJ |title=Slim defines a novel family of LIM-proteins expressed in skeletal muscle. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 2 |pages= 632-8 |year= 1996 |pmid= 8753811 |doi= 10.1006/bbrc.1996.1222 }}
+* {{cite journal | vauthors = Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M | title = The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2. | journal = J. Biol. Chem. | volume = 278 | issue = 15 | pages = 12786–95 | year = 2003 | pmid = 12556451 | doi = 10.1074/jbc.M300587200 }}
-*{{cite journal  | author=Morgan MJ, Madgwick AJ |title=The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 2 |pages= 245-50 |year= 1999 |pmid= 10049693 |doi= 10.1006/bbrc.1999.0179 }}
+* {{cite journal | vauthors = Mils V, Lee SM, Joly W, Hang EW, Baldin V, Waye MM, Ducommun B, Tsui SK | title = LIM-only protein FHL3 interacts with CDC25B2 phosphatase. | journal = Exp. Cell Res. | volume = 285 | issue = 1 | pages = 99–106 | year = 2003 | pmid = 12681290 | doi = 10.1016/S0014-4827(03)00018-1 }}
-*{{cite journal  | author=Lee SM, Tsui SK, Chan KK, ''et al.'' |title=Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1. |journal=Somat. Cell Mol. Genet. |volume=24 |issue= 3 |pages= 197-202 |year= 1999 |pmid= 10226657 |doi=  }}
+* {{cite journal | vauthors = Coghill ID, Brown S, Cottle DL, McGrath MJ, Robinson PA, Nandurkar HH, Dyson JM, Mitchell CA | title = FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly. | journal = J. Biol. Chem. | volume = 278 | issue = 26 | pages = 24139–52 | year = 2003 | pmid = 12704194 | doi = 10.1074/jbc.M213259200 }}
-*{{cite journal  | author=Li HY, Ng EK, Lee SM, ''et al.'' |title=Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET). |journal=J. Cell. Biochem. |volume=80 |issue= 3 |pages= 293-303 |year= 2001 |pmid= 11135358 |doi=  }}
+* {{cite journal | vauthors = Purcell NH, Darwis D, Bueno OF, Müller JM, Schüle R, Molkentin JD | title = Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. | journal = Mol. Cell. Biol. | volume = 24 | issue = 3 | pages = 1081–95 | year = 2004 | pmid = 14729955 | pmc = 321437 | doi = 10.1128/MCB.24.3.1081-1095.2004 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V | title = The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. | journal = J. Biol. Chem. | volume = 279 | issue = 27 | pages = 28641–52 | year = 2004 | pmid = 15117962 | doi = 10.1074/jbc.M312894200 }}
-*{{cite journal  | author=Turner J, Nicholas H, Bishop D, ''et al.'' |title=The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2. |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 12786-95 |year= 2003 |pmid= 12556451 |doi= 10.1074/jbc.M300587200 }}
+* {{cite journal | vauthors = Takahashi K, Matsumoto C, Ra C | title = FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1. | journal = Biochem. J. | volume = 386 | issue = Pt 1 | pages = 191–200 | year = 2005 | pmid = 15453830 | pmc = 1134781 | doi = 10.1042/BJ20040775 }}
-*{{cite journal  | author=Mils V, Lee SM, Joly W, ''et al.'' |title=LIM-only protein FHL3 interacts with CDC25B2 phosphatase. |journal=Exp. Cell Res. |volume=285 |issue= 1 |pages= 99-106 |year= 2003 |pmid= 12681290 |doi=  }}
+* {{cite journal | vauthors = Philippar U, Schratt G, Dieterich C, Müller JM, Galgóczy P, Engel FB, Keating MT, Gertler F, Schüle R, Vingron M, Nordheim A | title = The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. | journal = Mol. Cell | volume = 16 | issue = 6 | pages = 867–80 | year = 2005 | pmid = 15610731 | doi = 10.1016/j.molcel.2004.11.039 }}
-*{{cite journal  | author=Coghill ID, Brown S, Cottle DL, ''et al.'' |title=FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 24139-52 |year= 2003 |pmid= 12704194 |doi= 10.1074/jbc.M213259200 }}
+* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein–protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
-*{{cite journal  | author=Purcell NH, Darwis D, Bueno OF, ''et al.'' |title=Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1081-95 |year= 2004 |pmid= 14729955 |doi=  }}
+* {{cite journal | vauthors = Cottle DL, McGrath MJ, Cowling BS, Coghill ID, Brown S, Mitchell CA | title = FHL3 binds MyoD and negatively regulates myotube formation. | journal = J. Cell Sci. | volume = 120 | issue = Pt 8 | pages = 1423–35 | year = 2007 | pmid = 17389685 | doi = 10.1242/jcs.004739 }}
-*{{cite journal  | author=Samson T, Smyth N, Janetzky S, ''et al.'' |title=The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28641-52 |year= 2004 |pmid= 15117962 |doi= 10.1074/jbc.M312894200 }}
-*{{cite journal  | author=Takahashi K, Matsumoto C, Ra C |title=FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1. |journal=Biochem. J. |volume=386 |issue= Pt 1 |pages= 191-200 |year= 2005 |pmid= 15453830 |doi= 10.1042/BJ20040775 }}
-*{{cite journal  | author=Philippar U, Schratt G, Dieterich C, ''et al.'' |title=The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. |journal=Mol. Cell |volume=16 |issue= 6 |pages= 867-80 |year= 2005 |pmid= 15610731 |doi= 10.1016/j.molcel.2004.11.039 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Cottle DL, McGrath MJ, Cowling BS, ''et al.'' |title=FHL3 binds MyoD and negatively regulates myotube formation. |journal=J. Cell. Sci. |volume=120 |issue= Pt 8 |pages= 1423-35 |year= 2007 |pmid= 17389685 |doi= 10.1242/jcs.004739 }}
-}}
 {{refend}}
@@ Line 80: / Line 35: @@
 * {{MeshName|FHL3+protein,+human}}
+{{PDB Gallery|geneid=2275}}
+{{Transcription factors|g3}}
+{{NLM content}}
-{{protein-stub}}
-{{NLM content}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-1-stub}}

FHL3: Difference between revisions

Latest revision as of 19:55, 8 November 2017

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