ETV6

Ets variant gene 6 (TEL oncogene)
PDB rendering based on 1ji7.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ji7​, 1lky​, 2dao​
Identifiers
Symbols	ETV6 ; TEL; TEL/ABL
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37560
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ETV6 is an oncogene.

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

See also

• TEL-JAK2

Further reading

• Keung YK, Beaty M, Steward W; et al. (2003). "Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature". Cancer Genet. Cytogenet. 138 (2): 139–42. PMID 12505259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fainstein E, Einat M, Gokkel E; et al. (1990). "Nucleotide sequence analysis of human abl and bcr-abl cDNAs". Oncogene. 4 (12): 1477–81. PMID 2687768.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buijs A, Sherr S, van Baal S; et al. (1995). "Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8): 1511–9. PMID 7731705.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Golub TR, Barker GF, Bohlander SK; et al. (1995). "Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 4917–21. PMID 7761424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Romana SP, Mauchauffé M, Le Coniat M; et al. (1995). "The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion". Blood. 85 (12): 3662–70. PMID 7780150.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papadopoulos P, Ridge SA, Boucher CA; et al. (1995). "The novel activation of ABL by fusion to an ets-related gene, TEL". Cancer Res. 55 (1): 34–8. PMID 7805037.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Golub TR, Barker GF, Lovett M, Gilliland DG (1994). "Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation". Cell. 77 (2): 307–16. PMID 8168137.CS1 maint: Multiple names: authors list (link)
• Wlodarska I, Baens M, Peeters P; et al. (1996). "Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case". Cancer Res. 56 (11): 2655–61. PMID 8653712.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baens M, Peeters P, Guo C; et al. (1996). "Genomic organization of TEL: the human ETS-variant gene 6". Genome Res. 6 (5): 404–13. PMID 8743990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andreasson P, Johansson B, Arheden K; et al. (1997). "Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities". Genes Chromosomes Cancer. 19 (2): 77–83. PMID 9171997.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lacronique V, Boureux A, Valle VD; et al. (1997). "A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia". Science. 278 (5341): 1309–12. PMID 9360930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knezevich SR, McFadden DE, Tao W; et al. (1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma". Nat. Genet. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kwiatkowski BA, Bastian LS, Bauer TR; et al. (1998). "The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity". J. Biol. Chem. 273 (28): 17525–30. PMID 9651344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hannemann JR, McManus DM, Kabarowski JH, Wiedemann LM (1998). "Haemopoietic transformation by the TEL/ABL oncogene". Br. J. Haematol. 102 (2): 475–85. PMID 9695962.CS1 maint: Multiple names: authors list (link)
• Chakrabarti SR, Sood R, Ganguly S; et al. (1999). "Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9". Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7467–72. PMID 10377438.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cools J, Bilhou-Nabera C, Wlodarska I; et al. (1999). "Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13)". Blood. 94 (5): 1820–4. PMID 10477709.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yagasaki F, Jinnai I, Yoshida S; et al. (2000). "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)". Genes Chromosomes Cancer. 26 (3): 192–202. PMID 10502316.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wai DH, Knezevich SR, Lucas T; et al. (2000). "The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells". Oncogene. 19 (7): 906–15. doi:10.1038/sj.onc.1203396. PMID 10702799.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• ETV6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.