EHF (gene)

Ets homologous factor
Identifiers
Symbols	EHF ; ESE3; ESEJ
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7301
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ets homologous factor, also known as EHF, is a human gene.

This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.

Further reading

• Fujikawa M, Katagiri T, Tugores A; et al. (2007). "ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence". Cancer Sci. 98 (9): 1468–75. doi:10.1111/j.1349-7006.2007.00543.x. PMID 17627613.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park C, Lee I, Kang WK (2007). "Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis". Mol. Cancer Ther. 5 (12): 3191–6. doi:10.1158/1535-7163.MCT-06-0570. PMID 17172423.CS1 maint: Multiple names: authors list (link)
• Lim JH, Cho JY, Park YB; et al. (2006). "ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites". Biochem. Biophys. Res. Commun. 350 (3): 736–41. doi:10.1016/j.bbrc.2006.09.102. PMID 17027647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taylor TD, Noguchi H, Totoki Y; et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Appel S, Bringmann A, Grünebach F; et al. (2006). "Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs". Blood. 107 (8): 3265–70. doi:10.1182/blood-2005-06-2480. PMID 16380452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Silverman ES, Baron RM, Palmer LJ; et al. (2003). "Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung". Am. J. Respir. Cell Mol. Biol. 27 (6): 697–704. PMID 12444029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tugores A, Le J, Sorokina I; et al. (2001). "The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades". J. Biol. Chem. 276 (23): 20397–406. doi:10.1074/jbc.M010930200. PMID 11259407.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kas K, Finger E, Grall F; et al. (2000). "ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1". J. Biol. Chem. 275 (4): 2986–98. PMID 10644770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleinbaum LA, Duggan C, Ferreira E; et al. (1999). "Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF". Biochem. Biophys. Res. Commun. 264 (1): 119–26. doi:10.1006/bbrc.1999.1493. PMID 10527851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)

External links

• EHF+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.