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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein CBFA2T2''' is a [[protein]] that in humans is encoded by the ''CBFA2T2'' [[gene]].<ref name="pmid9790752">{{cite journal | vauthors = Calabi F, Cilli V | title = CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family | journal = Genomics | volume = 52 | issue = 3 | pages = 332–41 | date = December 1998 | pmid = 9790752 | pmc = | doi = 10.1006/geno.1998.5429 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9139| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Core-binding factor, runt domain, alpha subunit 2; translocated to, 2
| HGNCid = 1536
| Symbol = CBFA2T2
| AltSymbols =; DKFZp313F2116; EHT; MTGR1; ZMYND3
| OMIM = 603672
| ECnumber = 
| Homologene = 3733
| MGIid = 1333833
| GeneAtlas_image1 = PBB_GE_CBFA2T2_207625_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CBFA2T2_209144_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CBFA2T2_209145_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9139
    | Hs_Ensembl = ENSG00000078699
    | Hs_RefseqProtein = NP_001028171
    | Hs_RefseqmRNA = NM_001032999
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 31541589
    | Hs_GenLoc_end = 31701503
    | Hs_Uniprot = O43439
    | Mm_EntrezGene = 12396
    | Mm_Ensembl = ENSMUSG00000038533
    | Mm_RefseqmRNA = NM_172860
    | Mm_RefseqProtein = NP_766448
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 154127934
    | Mm_GenLoc_end = 154230797
    | Mm_Uniprot = Q30BK8
  }}
}}
'''Core-binding factor, runt domain, alpha subunit 2; translocated to, 2''', also known as '''CBFA2T2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9139| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.<ref name="entrez">{{cite web | title = Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9139| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CBFA2T2 has been shown to [[Protein–protein interaction|interact]] with [[RUNX1T1]].<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein–protein interaction network|authorlink30= Huda Zoghbi | journal = [[Nature (journal)|Nature]] | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid14703694>{{cite journal | vauthors = Lindberg SR, Olsson A, Persson AM, Olsson I | title = Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins | journal = Eur. J. Haematol. | volume = 71 | issue = 6 | pages = 439–47 | date = December 2003 | pmid = 14703694 | doi = 10.1046/j.0902-4441.2003.00166.x }}</ref><ref name=pmid12242670>{{cite journal | vauthors = Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N | title = The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies | journal = Oncogene | volume = 21 | issue = 43 | pages = 6703–12 | date = September 2002 | pmid = 12242670 | doi = 10.1038/sj.onc.1205882 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y, Ohki M | title = The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. | journal = Mol. Cell. Biol. | volume = 18 | issue = 2 | pages = 846–58 | year = 1998 | pmid = 9447981 | pmc = 108796 | doi =  }}
| citations =
* {{cite journal | vauthors = Fracchiolla NS, Colombo G, Finelli P, Maiolo AT, Neri A | title = EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias. | journal = Blood | volume = 92 | issue = 9 | pages = 3481–4 | year = 1998 | pmid = 9787195 | doi =  }}
*{{cite journal | author=Kitabayashi I, Ida K, Morohoshi F, ''et al.'' |title=The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 846-58 |year= 1998 |pmid= 9447981 |doi=  }}
* {{cite journal | vauthors = Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M | title = Structure and expression pattern of a human MTG8/ETO family gene, MTGR1. | journal = Gene | volume = 241 | issue = 2 | pages = 287–95 | year = 2000 | pmid = 10675041 | doi = 10.1016/S0378-1119(99)00481-3 }}
*{{cite journal | author=Fracchiolla NS, Colombo G, Finelli P, ''et al.'' |title=EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias. |journal=Blood |volume=92 |issue= 9 |pages= 3481-4 |year= 1998 |pmid= 9787195 |doi=  }}
* {{cite journal | vauthors = Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N | title = The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies. | journal = Oncogene | volume = 21 | issue = 43 | pages = 6703–12 | year = 2002 | pmid = 12242670 | doi = 10.1038/sj.onc.1205882 }}
*{{cite journal | author=Calabi F, Cilli V |title=CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. |journal=Genomics |volume=52 |issue= 3 |pages= 332-41 |year= 1998 |pmid= 9790752 |doi= 10.1006/geno.1998.5429 }}
* {{cite journal | vauthors = Lindberg SR, Olsson A, Persson AM, Olsson I | title = Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. | journal = Eur. J. Haematol. | volume = 71 | issue = 6 | pages = 439–47 | year = 2004 | pmid = 14703694 | doi = 10.1046/j.0902-4441.2003.00166.x }}
*{{cite journal  | author=Morohoshi F, Mitani S, Mitsuhashi N, ''et al.'' |title=Structure and expression pattern of a human MTG8/ETO family gene, MTGR1. |journal=Gene |volume=241 |issue= 2 |pages= 287-95 |year= 2000 |pmid= 10675041 |doi=  }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. | journal = Nat. Biotechnol. | volume = 22 | issue = 6 | pages = 707–16 | year = 2005 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Hoogeveen AT, Rossetti S, Stoyanova V, ''et al.'' |title=The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies. |journal=Oncogene |volume=21 |issue= 43 |pages= 6703-12 |year= 2002 |pmid= 12242670 |doi= 10.1038/sj.onc.1205882 }}
* {{cite journal | vauthors = Zhang J, Kalkum M, Yamamura S, Chait BT, Roeder RG | title = E protein silencing by the leukemogenic AML1-ETO fusion protein. | journal = Science | volume = 305 | issue = 5688 | pages = 1286–9 | year = 2004 | pmid = 15333839 | doi = 10.1126/science.1097937 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein–protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Lindberg SR, Olsson A, Persson AM, Olsson I |title=Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. |journal=Eur. J. Haematol. |volume=71 |issue= 6 |pages= 439-47 |year= 2004 |pmid= 14703694 |doi= }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein–protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
* {{cite journal | vauthors = Kumar R, Manning J, Spendlove HE, Kremmidiotis G, McKirdy R, Lee J, Millband DN, Cheney KM, Stampfer MR, Dwivedi PP, Morris HA, Callen DF | title = ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. | journal = Mol. Cancer Res. | volume = 4 | issue = 9 | pages = 655–65 | year = 2006 | pmid = 16966434 | doi = 10.1158/1541-7786.MCR-05-0249 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Zhang J, Kalkum M, Yamamura S, ''et al.'' |title=E protein silencing by the leukemogenic AML1-ETO fusion protein. |journal=Science |volume=305 |issue= 5688 |pages= 1286-9 |year= 2004 |pmid= 15333839 |doi= 10.1126/science.1097937 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Kumar R, Manning J, Spendlove HE, ''et al.'' |title=ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. |journal=Mol. Cancer Res. |volume=4 |issue= 9 |pages= 655-65 |year= 2006 |pmid= 16966434 |doi= 10.1158/1541-7786.MCR-05-0249 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|CBFA2T2+protein,+human}}
* {{MeshName|CBFA2T2+protein,+human}}
* {{UCSC gene info|CBFA2T2}}


{{NLM content}}
{{Transcription factors|g4}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-20-stub}}

Latest revision as of 05:29, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.[1][2]

Function

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.[2]

Interactions

CBFA2T2 has been shown to interact with RUNX1T1.[3][4][5]

References

  1. ↑ Calabi F, Cilli V (December 1998). "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family". Genomics. 52 (3): 332–41. doi:10.1006/geno.1998.5429. PMID 9790752.
  2. ↑ 2.0 2.1 "Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2".
  3. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  4. ↑ Lindberg SR, Olsson A, Persson AM, Olsson I (December 2003). "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439–47. doi:10.1046/j.0902-4441.2003.00166.x. PMID 14703694.
  5. ↑ Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N (September 2002). "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies". Oncogene. 21 (43): 6703–12. doi:10.1038/sj.onc.1205882. PMID 12242670.

Further reading

  • Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y, Ohki M (1998). "The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1". Mol. Cell. Biol. 18 (2): 846–58. PMC 108796. PMID 9447981.
  • Fracchiolla NS, Colombo G, Finelli P, Maiolo AT, Neri A (1998). "EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias". Blood. 92 (9): 3481–4. PMID 9787195.
  • Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1". Gene. 241 (2): 287–95. doi:10.1016/S0378-1119(99)00481-3. PMID 10675041.
  • Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N (2002). "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies". Oncogene. 21 (43): 6703–12. doi:10.1038/sj.onc.1205882. PMID 12242670.
  • Lindberg SR, Olsson A, Persson AM, Olsson I (2004). "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439–47. doi:10.1046/j.0902-4441.2003.00166.x. PMID 14703694.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Zhang J, Kalkum M, Yamamura S, Chait BT, Roeder RG (2004). "E protein silencing by the leukemogenic AML1-ETO fusion protein". Science. 305 (5688): 1286–9. doi:10.1126/science.1097937. PMID 15333839.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein–protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Kumar R, Manning J, Spendlove HE, Kremmidiotis G, McKirdy R, Lee J, Millband DN, Cheney KM, Stampfer MR, Dwivedi PP, Morris HA, Callen DF (2006). "ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription". Mol. Cancer Res. 4 (9): 655–65. doi:10.1158/1541-7786.MCR-05-0249. PMID 16966434.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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