BACH1

BTB and CNC homology 1, basic leucine zipper transcription factor 1
PDB rendering based on 2ihc.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ihc​
Identifiers
Symbols	BACH1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 916
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

BTB and CNC homology 1, basic leucine zipper transcription factor 1, also known as BACH1, is a human gene.

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.

Further reading

• Ozono R (2006). "New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway". Current pharmaceutical biotechnology. 7 (2): 87–93. PMID 16724942.
• Oyake T, Itoh K, Motohashi H; et al. (1996). "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site". Mol. Cell. Biol. 16 (11): 6083–95. PMID 8887638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Ohira M, Seki N, Nagase T; et al. (1998). "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1". Genomics. 47 (2): 300–6. PMID 9479503.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blouin JL, Duriaux Saïl G, Guipponi M; et al. (1998). "Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1". Hum. Genet. 102 (3): 282–8. PMID 9544839.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi A, Yamagiwa H, Hoshino H; et al. (2000). "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain". Mol. Cell. Biol. 20 (5): 1733–46. PMID 10669750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kanezaki R, Toki T, Yokoyama M; et al. (2001). "Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform". J. Biol. Chem. 276 (10): 7278–84. doi:10.1074/jbc.M004227200. PMID 11069897.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cantor SB, Bell DW, Ganesan S; et al. (2001). "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function". Cell. 105 (1): 149–60. PMID 11301010.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kitamuro T, Takahashi K, Ogawa K; et al. (2003). "Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells". J. Biol. Chem. 278 (11): 9125–33. doi:10.1074/jbc.M209939200. PMID 12511571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki H, Tashiro S, Sun J; et al. (2004). "Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene". J. Biol. Chem. 278 (49): 49246–53. doi:10.1074/jbc.M306764200. PMID 14504288.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tahara T, Sun J, Nakanishi K; et al. (2004). "Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells". J. Biol. Chem. 279 (7): 5480–7. doi:10.1074/jbc.M302733200. PMID 14660636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shim KS, Ferrando-Miguel R, Lubec G (2004). "Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease". J. Neural Transm. Suppl. (67): 39–49. PMID 15068237.CS1 maint: Multiple names: authors list (link)
• Ferrando-Miguel R, Cheon MS, Yang JW, Lubec G (2004). "Overexpression of transcription factor BACH1 in fetal Down syndrome brain". J. Neural Transm. Suppl. (67): 193–205. PMID 15068251.CS1 maint: Multiple names: authors list (link)
• Suzuki H, Tashiro S, Hira S; et al. (2005). "Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1". EMBO J. 23 (13): 2544–53. doi:10.1038/sj.emboj.7600248. PMID 15175654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tahara T, Sun J, Igarashi K, Taketani S (2004). "Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells". Biochem. Biophys. Res. Commun. 324 (1): 77–85. doi:10.1016/j.bbrc.2004.09.022. PMID 15464985.CS1 maint: Multiple names: authors list (link)
• Shan Y, Lambrecht RW, Ghaziani T; et al. (2005). "Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS". J. Biol. Chem. 279 (50): 51769–74. doi:10.1074/jbc.M409463200. PMID 15465821.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toki T, Katsuoka F, Kanezaki R; et al. (2005). "Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment". Blood. 105 (8): 3100–8. doi:10.1182/blood-2004-07-2826. PMID 15613547.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• BACH1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.