ATOH1

Atonal homolog 1 (Drosophila)
Identifiers
Symbols	ATOH1 ; ATH1; HATH1; MATH-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31297
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Atonal homolog 1 (Drosophila), also known as ATOH1, is a human gene.

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.

Further reading

• Leow CC, Polakis P, Gao WQ (2006). "A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma". Ann. N. Y. Acad. Sci. 1059: 174–83. doi:10.1196/annals.1339.048. PMID 16382053.CS1 maint: Multiple names: authors list (link)
• Ben-Arie N, McCall AE, Berkman S; et al. (1997). "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis". Hum. Mol. Genet. 5 (9): 1207–16. PMID 8872459.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Helms AW, Johnson JE (1998). "Progenitors of dorsal commissural interneurons are defined by MATH1 expression". Development. 125 (5): 919–28. PMID 9449674.
• Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
• Brown NL, Dagenais SL, Chen CM, Glaser T (2002). "Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development". Mamm. Genome. 13 (2): 95–101. doi:10.1007/s00335-001-2101-3. PMID 11889557.CS1 maint: Multiple names: authors list (link)
• Leonard JH, Cook AL, Van Gele M; et al. (2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma". Int. J. Cancer. 101 (2): 103–10. doi:10.1002/ijc.10554. PMID 12209986.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gazit R, Krizhanovsky V, Ben-Arie N (2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway". Development. 131 (4): 903–13. doi:10.1242/dev.00982. PMID 14757642.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sekine A, Akiyama Y, Yanagihara K, Yuasa Y (2006). "Hath1 up-regulates gastric mucin gene expression in gastric cells". Biochem. Biophys. Res. Commun. 344 (4): 1166–71. doi:10.1016/j.bbrc.2006.03.238. PMID 16647036.CS1 maint: Multiple names: authors list (link)
• Mutoh H, Sakamoto H, Hayakawa H; et al. (2006). "The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1". Differentiation. 74 (6): 313–21. doi:10.1111/j.1432-0436.2006.00074.x. PMID 16831200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park ET, Oh HK, Gum JR; et al. (2006). "HATH1 expression in mucinous cancers of the colorectum and related lesions". Clin. Cancer Res. 12 (18): 5403–10. doi:10.1158/1078-0432.CCR-06-0573. PMID 17000673.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsuchiya K, Nakamura T, Okamoto R; et al. (2007). "Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer". Gastroenterology. 132 (1): 208–20. doi:10.1053/j.gastro.2006.10.031. PMID 17241872.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Du X, Jensen P, Goldowitz D, Hamre KM (2007). "Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice". Dev. Biol. 305 (2): 430–8. doi:10.1016/j.ydbio.2007.02.028. PMID 17397818.CS1 maint: Multiple names: authors list (link)
• Westerman BA, Breuer RH, Poutsma A; et al. (2007). "Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors". Int. J. Biol. Markers. 22 (2): 114–23. PMID 17549667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheffer D, Sage C, Corey DP, Pingault V (2007). "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells". FEBS Lett. 581 (24): 4651–6. doi:10.1016/j.febslet.2007.08.059. PMID 17826772.CS1 maint: Multiple names: authors list (link)

External links

• ATOH1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.