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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein atonal homolog 1''' is a [[protein]] that in humans is encoded by the ''ATOH1'' [[gene]].<ref name="pmid8872459">{{cite journal | vauthors = Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY|authorlink6=Huda Zoghbi | title = Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis | journal = Human Molecular Genetics | volume = 5 | issue = 9 | pages = 1207–16 | date = Sep 1996 | pmid = 8872459 | pmc =  | doi = 10.1093/hmg/5.9.1207 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=474| accessdate = }}</ref>
| update_page = yes
 
| require_manual_inspection = no
== Function ==
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This protein belongs to the [[basic helix-loop-helix]] (BHLH) family of [[transcription factor]]s. It activates E-box dependent transcription along with E47.<ref name="entrez" /> ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian homolog of the ''Drosophila melanogaster'' gene ''atonal''.  ATOH1 is considered part of the [[Notch signaling pathway]].
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Atonal homolog 1 (Drosophila)
| HGNCid = 797
| Symbol = ATOH1
| AltSymbols =; ATH1; HATH1; MATH-1
| OMIM = 601461
| ECnumber = 
| Homologene = 31297
| MGIid = 104654
| GeneAtlas_image1 = PBB_GE_ATOH1_221336_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0031490 |text = chromatin DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0042472 |text = inner ear morphogenesis}} {{GNF_GO|id=GO:0042491 |text = auditory receptor cell differentiation}} {{GNF_GO|id=GO:0042667 |text = auditory receptor cell fate specification}} {{GNF_GO|id=GO:0042668 |text = auditory receptor cell fate determination}} {{GNF_GO|id=GO:0045609 |text = positive regulation of auditory receptor cell differentiation}} {{GNF_GO|id=GO:0045664 |text = regulation of neuron differentiation}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 474
    | Hs_Ensembl = ENSG00000172238
    | Hs_RefseqProtein = NP_005163
    | Hs_RefseqmRNA = NM_005172
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 94969100
    | Hs_GenLoc_end = 94970165
    | Hs_Uniprot = Q92858
    | Mm_EntrezGene = 11921
    | Mm_Ensembl = ENSMUSG00000073043
    | Mm_RefseqmRNA = NM_007500
    | Mm_RefseqProtein = NP_031526
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 64658703
    | Mm_GenLoc_end = 64660810
    | Mm_Uniprot = P48985
  }}
}}
'''Atonal homolog 1 (Drosophila)''', also known as '''ATOH1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=474| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
In 2009, ATOH1 was identified as a "cancer switch-off" gene. [https://www.google.com/hostednews/ukpress/article/ALeqM5hQ2QmN4PXatalHzUnF-7BM1f78rA]
{{PBB_Summary
| section_title =
| summary_text = This protein belongs to the [[basic helix-loop-helix]] (BHLH) family of [[transcription factor]]s. It activates E-box dependent transcription along with E47.<ref name="entrez">{{cite web | title = Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=474| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Helms AW, Johnson JE | title = Progenitors of dorsal commissural interneurons are defined by MATH1 expression | journal = Development | volume = 125 | issue = 5 | pages = 919–28 | date = Mar 1998 | pmid = 9449674 | doi =  }}
| citations =
* {{cite journal | vauthors = Dintilhac A, Bernués J | title = HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7021–8 | date = Mar 2002 | pmid = 11748221 | doi = 10.1074/jbc.M108417200 | url = https://digital.csic.es/bitstream/10261/112516/4/jbc.M108417200.full.pdf }}
*{{cite journal  | author=Leow CC, Polakis P, Gao WQ |title=A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma. |journal=Ann. N. Y. Acad. Sci. |volume=1059 |issue=  |pages= 174-83 |year= 2006 |pmid= 16382053 |doi= 10.1196/annals.1339.048 }}
* {{cite journal | vauthors = Brown NL, Dagenais SL, Chen CM, Glaser T | title = Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development | journal = Mammalian Genome | volume = 13 | issue = 2 | pages = 95–101 | date = Feb 2002 | pmid = 11889557 | pmc = 2262845 | doi = 10.1007/s00335-001-2101-3 }}
*{{cite journal  | author=Ben-Arie N, McCall AE, Berkman S, ''et al.'' |title=Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. |journal=Hum. Mol. Genet. |volume=5 |issue= 9 |pages= 1207-16 |year= 1997 |pmid= 8872459 |doi=  }}
* {{cite journal | vauthors = Leonard JH, Cook AL, Van Gele M, Boyle GM, Inglis KJ, Speleman F, Sturm RA | title = Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma | journal = International Journal of Cancer | volume = 101 | issue = 2 | pages = 103–10 | date = Sep 2002 | pmid = 12209986 | doi = 10.1002/ijc.10554 }}
*{{cite journal | author=Helms AW, Johnson JE |title=Progenitors of dorsal commissural interneurons are defined by MATH1 expression. |journal=Development |volume=125 |issue= 5 |pages= 919-28 |year= 1998 |pmid= 9449674 |doi=  }}
* {{cite journal | vauthors = Gazit R, Krizhanovsky V, Ben-Arie N | title = Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway | journal = Development | volume = 131 | issue = 4 | pages = 903–13 | date = Feb 2004 | pmid = 14757642 | doi = 10.1242/dev.00982 }}
*{{cite journal | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021-8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
* {{cite journal | vauthors = Leow CC, Polakis P, Gao WQ | title = A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma | journal = Annals of the New York Academy of Sciences | volume = 1059 | issue = | pages = 174–83 | date = Nov 2005 | pmid = 16382053 | doi = 10.1196/annals.1339.048 }}
*{{cite journal | author=Brown NL, Dagenais SL, Chen CM, Glaser T |title=Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. |journal=Mamm. Genome |volume=13 |issue= 2 |pages= 95-101 |year= 2002 |pmid= 11889557 |doi= 10.1007/s00335-001-2101-3 }}
* {{cite journal | vauthors = Sekine A, Akiyama Y, Yanagihara K, Yuasa Y | title = Hath1 up-regulates gastric mucin gene expression in gastric cells | journal = Biochemical and Biophysical Research Communications | volume = 344 | issue = 4 | pages = 1166–71 | date = Jun 2006 | pmid = 16647036 | doi = 10.1016/j.bbrc.2006.03.238 }}
*{{cite journal | author=Leonard JH, Cook AL, Van Gele M, ''et al.'' |title=Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. |journal=Int. J. Cancer |volume=101 |issue= 2 |pages= 103-10 |year= 2002 |pmid= 12209986 |doi= 10.1002/ijc.10554 }}
* {{cite journal | vauthors = Mutoh H, Sakamoto H, Hayakawa H, Arao Y, Satoh K, Nokubi M, Sugano K | title = The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1 | journal = Differentiation; Research in Biological Diversity | volume = 74 | issue = 6 | pages = 313–21 | date = Jul 2006 | pmid = 16831200 | doi = 10.1111/j.1432-0436.2006.00074.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Park ET, Oh HK, Gum JR, Crawley SC, Kakar S, Engel J, Leow CC, Gao WQ, Kim YS | title = HATH1 expression in mucinous cancers of the colorectum and related lesions | journal = Clinical Cancer Research | volume = 12 | issue = 18 | pages = 5403–10 | date = Sep 2006 | pmid = 17000673 | doi = 10.1158/1078-0432.CCR-06-0573 }}
*{{cite journal  | author=Gazit R, Krizhanovsky V, Ben-Arie N |title=Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. |journal=Development |volume=131 |issue= 4 |pages= 903-13 |year= 2004 |pmid= 14757642 |doi= 10.1242/dev.00982 }}
* {{cite journal | vauthors = Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M | title = Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer | journal = Gastroenterology | volume = 132 | issue = 1 | pages = 208–20 | date = Jan 2007 | pmid = 17241872 | doi = 10.1053/j.gastro.2006.10.031 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Du X, Jensen P, Goldowitz D, Hamre KM | title = Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice | journal = Developmental Biology | volume = 305 | issue = 2 | pages = 430–8 | date = May 2007 | pmid = 17397818 | doi = 10.1016/j.ydbio.2007.02.028 }}
*{{cite journal | author=Sekine A, Akiyama Y, Yanagihara K, Yuasa Y |title=Hath1 up-regulates gastric mucin gene expression in gastric cells. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 4 |pages= 1166-71 |year= 2006 |pmid= 16647036 |doi= 10.1016/j.bbrc.2006.03.238 }}
* {{cite journal | vauthors = Westerman BA, Breuer RH, Poutsma A, Chhatta A, Noorduyn LA, Koolen MG, Postmus PE, Blankenstein MA, Oudejans CB | title = Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors | journal = The International Journal of Biological Markers | volume = 22 | issue = 2 | pages = 114–23 | year = 2007 | pmid = 17549667 | doi =  }}
*{{cite journal | author=Mutoh H, Sakamoto H, Hayakawa H, ''et al.'' |title=The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1. |journal=Differentiation |volume=74 |issue= 6 |pages= 313-21 |year= 2006 |pmid= 16831200 |doi= 10.1111/j.1432-0436.2006.00074.x }}
* {{cite journal | vauthors = Scheffer D, Sage C, Corey DP, Pingault V | title = Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells | journal = FEBS Letters | volume = 581 | issue = 24 | pages = 4651–6 | date = Oct 2007 | pmid = 17826772 | doi = 10.1016/j.febslet.2007.08.059 }}
*{{cite journal | author=Park ET, Oh HK, Gum JR, ''et al.'' |title=HATH1 expression in mucinous cancers of the colorectum and related lesions. |journal=Clin. Cancer Res. |volume=12 |issue= 18 |pages= 5403-10 |year= 2006 |pmid= 17000673 |doi= 10.1158/1078-0432.CCR-06-0573 }}
* {{cite journal | vauthors = Shroyer NF, Helmrath MA, Wang VY, Antalffy B, Henning SJ, Zoghbi HY | title = Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis | journal = Gastroenterology | volume = 132 | issue = 7 | pages = 2478–88 | date = Jun 2007 | pmid = 17570220 | doi = 10.1053/j.gastro.2007.03.047 }}
*{{cite journal | author=Tsuchiya K, Nakamura T, Okamoto R, ''et al.'' |title=Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. |journal=Gastroenterology |volume=132 |issue= 1 |pages= 208-20 |year= 2007 |pmid= 17241872 |doi= 10.1053/j.gastro.2006.10.031 }}
*{{cite journal | author=Du X, Jensen P, Goldowitz D, Hamre KM |title=Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice. |journal=Dev. Biol. |volume=305 |issue= 2 |pages= 430-8 |year= 2007 |pmid= 17397818 |doi= 10.1016/j.ydbio.2007.02.028 }}
*{{cite journal | author=Westerman BA, Breuer RH, Poutsma A, ''et al.'' |title=Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. |journal=Int. J. Biol. Markers |volume=22 |issue= 2 |pages= 114-23 |year= 2007 |pmid= 17549667 |doi=  }}
*{{cite journal | author=Scheffer D, Sage C, Corey DP, Pingault V |title=Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells. |journal=FEBS Lett. |volume=581 |issue= 24 |pages= 4651-6 |year= 2007 |pmid= 17826772 |doi= 10.1016/j.febslet.2007.08.059 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ATOH1+protein,+human}}
* {{MeshName|ATOH1+protein,+human}}
* [https://web.archive.org/web/20090426033208/http://www.scientistlive.com/Scientist-QA/Cancer%2Bgene%2Bsimilarities%2Bdiscovered/22179 ATOH1 and cancer suppression]
* {{UCSC gene info|ATOH1}}


{{Transcription factors|g1}}
{{Regulome
| activates = [[HES6]]
| inhibits =
| activated_by =
| inhibited_by =
}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-4-stub}}

Latest revision as of 12:06, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.[1][2]

Function

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.[2] ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal. ATOH1 is considered part of the Notch signaling pathway.

In 2009, ATOH1 was identified as a "cancer switch-off" gene. [2]

References

  1. ↑ Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY (Sep 1996). "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis". Human Molecular Genetics. 5 (9): 1207–16. doi:10.1093/hmg/5.9.1207. PMID 8872459.
  2. ↑ 2.0 2.1 "Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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