ATF6

Activating transcription factor 6
Identifiers
Symbols	ATF6 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32015
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Activating transcription factor 6, also known as ATF6, is a human gene.

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[supplied by OMIM]

See also

• Activating transcription factor

Further reading

• Hai T, Hartman MG (2001). "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis". Gene. 273 (1): 1–11. PMID 11483355.
• Hai TW, Liu F, Coukos WJ, Green MR (1990). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. 3 (12B): 2083–90. PMID 2516827.CS1 maint: Multiple names: authors list (link)
• Zhu C, Johansen FE, Prywes R (1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMID 9271374.CS1 maint: Multiple names: authors list (link)
• Yoshida H, Haze K, Yanagi H; et al. (1999). "Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors". J. Biol. Chem. 273 (50): 33741–9. PMID 9837962.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haze K, Yoshida H, Yanagi H; et al. (1999). "Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress". Mol. Biol. Cell. 10 (11): 3787–99. PMID 10564271.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li M, Baumeister P, Roy B; et al. (2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Mol. Cell. Biol. 20 (14): 5096–106. PMID 10866666.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshida H, Okada T, Haze K; et al. (2001). "Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response". Mol. Cell. Biol. 21 (4): 1239–48. doi:10.1128/MCB.21.4.1239-1248.2001. PMID 11158310.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ye J, Rawson RB, Komuro R; et al. (2001). "ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs". Mol. Cell. 6 (6): 1355–64. PMID 11163209.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Parker R, Phan T, Baumeister P; et al. (2001). "Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6". Mol. Cell. Biol. 21 (9): 3220–33. doi:10.1128/MCB.21.9.3220-3233.2001. PMID 11287625.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gotoh T, Oyadomari S, Mori K, Mori M (2002). "Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP". J. Biol. Chem. 277 (14): 12343–50. doi:10.1074/jbc.M107988200. PMID 11805088.CS1 maint: Multiple names: authors list (link)
• Chen X, Shen J, Prywes R (2002). "The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi". J. Biol. Chem. 277 (15): 13045–52. doi:10.1074/jbc.M110636200. PMID 11821395.CS1 maint: Multiple names: authors list (link)
• Thuerauf DJ, Morrison LE, Hoover H, Glembotski CC (2002). "Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16". J. Biol. Chem. 277 (23): 20734–9. doi:10.1074/jbc.M201749200. PMID 11909875.CS1 maint: Multiple names: authors list (link)
• Okada T, Yoshida H, Akazawa R; et al. (2002). "Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response". Biochem. J. 366 (Pt 2): 585–94. doi:10.1042/BJ20020391. PMID 12014989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luo S, Lee AS (2002). "Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation". Biochem. J. 366 (Pt 3): 787–95. doi:10.1042/BJ20011802. PMID 12076252.
• Tardif KD, Mori K, Siddiqui A (2002). "Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway". J. Virol. 76 (15): 7453–9. PMID 12097557.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shuda M, Kondoh N, Imazeki N; et al. (2004). "Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis". J. Hepatol. 38 (5): 605–14. PMID 12713871.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okada T, Haze K, Nadanaka S; et al. (2003). "A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6". J. Biol. Chem. 278 (33): 31024–32. doi:10.1074/jbc.M300923200. PMID 12782636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554.

External links

• ATF6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.