MAPK8

Mitogen-activated protein kinase 8
250px
PDB rendering based on 1jnk.
Available structures: 1jnk, 1pmn, 1pmq, 1pmu, 1pmv, 1ukh, 1uki, 2b1p, 2exc, 2g01, 2gmx, 2h96, 2no3, 2o0u, 2o2u, 2ok1
Identifiers
Symbol(s)	MAPK8; JNK; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1
External IDs	OMIM: 601158 MGI: 1346861 Homologene: 56760
Gene ontology Molecular Function: • nucleotide binding • protein serine/threonine kinase activity • JUN kinase activity • MAP kinase activity • protein binding • ATP binding • transferase activity Biological Process: • ossification • protein amino acid phosphorylation • cell motility • response to stress • signal transduction • JNK cascade
RNA expression pattern
250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	5599	26419
Ensembl	ENSG00000107643	ENSMUSG00000021936
Uniprot	P45983	Q544A0
Refseq	NM_002750 (mRNA) NP_002741 (protein)	NM_016700 (mRNA) NP_057909 (protein)
Location	Chr 10: 49.18 - 49.32 Mb	Chr 14: 32.21 - 32.28 Mb
Pubmed search	[1]	[2]

Mitogen-activated protein kinase 8, also known as MAPK8, is a human gene.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Further reading

• Davis RJ (2000). "Signal transduction by the JNK group of MAP kinases.". Cell 103 (2): 239-52. PMID 11057897.
• Liu J, Lin A (2007). "Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases.". Oncogene 26 (22): 3267-78. doi:10.1038/sj.onc.1210417. PMID 17496921.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.