Mitogen-activated protein kinase 8
|PDB rendering based on 1jnk.|
|Available structures:, , , , , , , , , , , , , , ,|
|RNA expression pattern|
Mitogen-activated protein kinase 8, also known as MAPK8, is a human gene.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
- Davis RJ (2000). "Signal transduction by the JNK group of MAP kinases.". Cell. 103 (2): 239–52. PMID 11057897.
- Liu J, Lin A (2007). "Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases.". Oncogene. 26 (22): 3267–78. PMID 17496921. doi:10.1038/sj.onc.1210417.