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Pyruvate dehydrogenase kinase, isozyme 3
PDB rendering based on 1y8n.
Available structures: 1y8n, 1y8o, 1y8p
Symbol(s) PDK3;
External IDs OMIM: 602526 MGI2384308 Homologene55897
RNA expression pattern



More reference expression data

Human Mouse
Entrez 5165 236900
Ensembl ENSG00000067992 ENSMUSG00000035232
Uniprot Q15120 Q3V250
Refseq NM_005391 (mRNA)
NP_005382 (protein)
NM_145630 (mRNA)
NP_663605 (protein)
Location Chr X: 24.39 - 24.46 Mb Chr X: 90.02 - 90.08 Mb
Pubmed search [1] [2]

Pyruvate dehydrogenase kinase, isozyme 3, also known as PDK3, is a human gene.[1] It codes for an isozyme of pyruvate dehydrogenase kinase.


Further reading

  • Sugden MC, Holness MJ (2003). "Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.". Curr. Drug Targets Immune Endocr. Metabol. Disord. 2 (2): 151–65. PMID 12476789. 
  • Sugden MC, Holness MJ (2003). "Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.". Am. J. Physiol. Endocrinol. Metab. 284 (5): E855–62. PMID 12676647. doi:10.1152/ajpendo.00526.2002. 
  • Gudi R, Bowker-Kinley MM, Kedishvili NY; et al. (1996). "Diversity of the pyruvate dehydrogenase kinase gene family in humans.". J. Biol. Chem. 270 (48): 28989–94. PMID 7499431. 
  • Baker JC, Yan X, Peng T; et al. (2000). "Marked differences between two isoforms of human pyruvate dehydrogenase kinase.". J. Biol. Chem. 275 (21): 15773–81. PMID 10748134. doi:10.1074/jbc.M909488199. 
  • Kolobova E, Tuganova A, Boulatnikov I, Popov KM (2001). "Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.". Biochem. J. 358 (Pt 1): 69–77. PMID 11485553. 
  • Korotchkina LG, Patel MS (2001). "Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.". J. Biol. Chem. 276 (40): 37223–9. PMID 11486000. doi:10.1074/jbc.M103069200. 
  • Tuganova A, Boulatnikov I, Popov KM (2002). "Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.". Biochem. J. 366 (Pt 1): 129–36. PMID 11978179. doi:10.1042/BJ20020301. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Spriet LL, Tunstall RJ, Watt MJ; et al. (2005). "Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting.". J. Appl. Physiol. 96 (6): 2082–7. PMID 14966024. doi:10.1152/japplphysiol.01318.2003. 
  • Blackshaw S, Harpavat S, Trimarchi J; et al. (2006). "Genomic analysis of mouse retinal development.". PLoS Biol. 2 (9): E247. PMID 15226823. doi:10.1371/journal.pbio.0020247. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Kato M, Chuang JL, Tso SC; et al. (2005). "Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.". EMBO J. 24 (10): 1763–74. PMID 15861126. doi:10.1038/sj.emboj.7600663. 
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  • Tso SC, Kato M, Chuang JL, Chuang DT (2006). "Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex.". J. Biol. Chem. 281 (37): 27197–204. PMID 16849321. doi:10.1074/jbc.M604339200. 
  • Devedjiev Y, Steussy CN, Vassylyev DG (2007). "Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications.". J. Mol. Biol. 370 (3): 407–16. PMID 17532006. doi:10.1016/j.jmb.2007.04.083. 
  • Degenhardt T, Saramäki A, Malinen M; et al. (2007). "Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.". J. Mol. Biol. 372 (2): 341–55. PMID 17669420. doi:10.1016/j.jmb.2007.06.091. 
  • Kato M, Li J, Chuang JL, Chuang DT (2007). "Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.". Structure. 15 (8): 992–1004. PMID 17683942. doi:10.1016/j.str.2007.07.001.