Receptor protein serine/threonine kinase

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In enzymology, a receptor protein serine/threonine kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + [receptor-protein] ADP + [receptor-protein] phosphate

Thus, the two substrates of this enzyme are ATP and [[[receptor-protein]]], whereas its two products are ADP and [[[receptor-protein] phosphate]].

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups protein-serine/threonine kinases. The systematic name of this enzyme class is ATP:[receptor-protein] phosphotransferase. Other names in common use include activin receptor kinase, receptor type I serine/threonine protein kinase, receptor type II serine/threonine protein kinase, STK13, TGF-beta kinase, and receptor serine/threonine protein kinase. This enzyme participates in 7 metabolic pathways: mapk signaling pathway, cytokine-cytokine receptor interaction, tgf-beta signaling pathway, adherens junction, colorectal cancer, pancreatic cancer, and chronic myeloid leukemia.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2GOO, 2H62, 2H64, 2HLQ, and 2HLR.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Wrana JL, Attisano L, Wieser R, Ventura F, Massague J (1994). "Mechanism of activation of the TGF-beta receptor". Nature. 370: 341&ndash, 7. PMID 8047140.
  • Massague J, Chen YG (2000). "Controlling TGF-beta signaling". Genes. Dev. 14: 627&ndash, 44. PMID 10733523.
  • Lechleider RJ (1997). "Characterization of functional domains within Smad4/DPC4". J. Biol. Chem. 272: 13690&ndash, 6. PMID 9153220.

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