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Mitogen-activated protein kinase kinase 1
PDB rendering based on 1s9j.
Available structures: 1s9j
Symbol(s) MAP2K1; MAPKK1; MEK1; MKK1; PRKMK1
External IDs OMIM: 176872 MGI1346866 Homologene2063
RNA expression pattern


More reference expression data

Human Mouse
Entrez 5604 26395
Ensembl ENSG00000169032 ENSMUSG00000004936
Uniprot Q02750 Q3TMJ8
Refseq NM_002755 (mRNA)
NP_002746 (protein)
NM_008927 (mRNA)
NP_032953 (protein)
Location Chr 15: 64.47 - 64.57 Mb Chr 9: 63.98 - 64.05 Mb
Pubmed search [1] [2]

Mitogen-activated protein kinase kinase 1, also known as MAP2K1, is a human gene.

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.[1]


Further reading

  • Wu J, Michel H, Rossomando A, Haystead T, Shabanowitz J, Hunt DF, Sturgill TW. (1992). "Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle". Biochem J. 285 (3): 701–5. PMID 1379797. 
  • Rossomando AJ, Dent P, Sturgill TW, Marshak DR. (1994). "Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation". Mol Cell Biol. 14 (3): 1594–602. PMID 8114697. 
  • Seger R, Krebs EG (1995). "The MAPK signaling cascade.". FASEB J. 9 (9): 726–35. PMID 7601337. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. PMID 15638726. 
  • Tanaka S, Nakamura K, Takahasi N, Suda T (2006). "Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system.". Immunol. Rev. 208: 30–49. PMID 16313339. doi:10.1111/j.0105-2896.2005.00327.x. 
  • Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57–64. PMID 16454711. 
  • Galabova-Kovacs G, Kolbus A, Matzen D; et al. (2006). "ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts.". Cell Cycle. 5 (14): 1514–8. PMID 16861903.