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Mitogen-activated protein kinase kinase 5
PDB rendering based on 1wi0.
Available structures: 1wi0, 2npt, 2o2v
Symbol(s) MAP2K5; HsT17454; MAPKK5; MEK5; PRKMK5
External IDs OMIM: 602520 MGI1346345 Homologene68937
RNA expression pattern




More reference expression data

Human Mouse
Entrez 5607 23938
Ensembl ENSG00000137764 ENSMUSG00000058444
Uniprot Q13163 Q3TM51
Refseq NM_002757 (mRNA)
NP_002748 (protein)
XM_981477 (mRNA)
XP_986571 (protein)
Location Chr 15: 65.62 - 65.89 Mb Chr 9: 62.96 - 63.18 Mb
Pubmed search [1] [2]

Mitogen-activated protein kinase kinase 5, also known as MAP2K5, is a human gene.[1]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.[1]


Further reading

  • English JM, Vanderbilt CA, Xu S; et al. (1996). "Isolation of MEK5 and differential expression of alternatively spliced forms.". J. Biol. Chem. 270 (48): 28897–902. PMID 7499418. 
  • Zhou G, Bao ZQ, Dixon JE (1995). "Components of a new human protein kinase signal transduction pathway.". J. Biol. Chem. 270 (21): 12665–9. PMID 7759517. 
  • Kato Y, Kravchenko VV, Tapping RI; et al. (1998). "BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.". EMBO J. 16 (23): 7054–66. PMID 9384584. doi:10.1093/emboj/16.23.7054. 
  • Kato Y, Tapping RI, Huang S; et al. (1998). "Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor.". Nature. 395 (6703): 713–6. PMID 9790194. doi:10.1038/27234. 
  • English JM, Pearson G, Hockenberry T; et al. (1999). "Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control.". J. Biol. Chem. 274 (44): 31588–92. PMID 10531364. 
  • Chao TH, Hayashi M, Tapping RI; et al. (2000). "MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway.". J. Biol. Chem. 274 (51): 36035–8. PMID 10593883. 
  • Sun W, Kesavan K, Schaefer BC; et al. (2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.". J. Biol. Chem. 276 (7): 5093–100. PMID 11073940. doi:10.1074/jbc.M003719200. 
  • Diaz-Meco MT, Moscat J (2001). "MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling.". Mol. Cell. Biol. 21 (4): 1218–27. PMID 11158308. doi:10.1128/MCB.21.4.1218-1227.2001. 
  • Nicol RL, Frey N, Pearson G; et al. (2001). "Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.". EMBO J. 20 (11): 2757–67. PMID 11387209. doi:10.1093/emboj/20.11.2757. 
  • Dinev D, Jordan BW, Neufeld B; et al. (2001). "Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells.". EMBO Rep. 2 (9): 829–34. PMID 11520859. doi:10.1093/embo-reports/kve177. 
  • Weldon CB, Scandurro AB, Rolfe KW; et al. (2002). "Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray.". Surgery. 132 (2): 293–301. PMID 12219026. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Mehta PB, Jenkins BL, McCarthy L; et al. (2003). "MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.". Oncogene. 22 (9): 1381–9. PMID 12618764. doi:10.1038/sj.onc.1206154. 
  • Mody N, Campbell DG, Morrice N; et al. (2003). "An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro.". Biochem. J. 372 (Pt 2): 567–75. PMID 12628002. doi:10.1042/BJ20030193. 
  • Huang J, Tu Z, Lee FS (2003). "Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity.". Biochem. Biophys. Res. Commun. 303 (2): 532–40. PMID 12659851. 
  • Lamark T, Perander M, Outzen H; et al. (2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.". J. Biol. Chem. 278 (36): 34568–81. PMID 12813044. doi:10.1074/jbc.M303221200. 
  • Cameron SJ, Abe J, Malik S; et al. (2004). "Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation.". J. Biol. Chem. 279 (2): 1506–12. PMID 14583600. doi:10.1074/jbc.M308755200. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. PMID 14743216. doi:10.1038/ncb1086. 
  • Raviv Z, Kalie E, Seger R (2004). "MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.". J. Cell. Sci. 117 (Pt 9): 1773–84. PMID 15075238. doi:10.1242/jcs.01040.