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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Interleukin-1 receptor-associated kinase 1''' is an [[enzyme]] that in humans is encoded by the ''IRAK1'' [[gene]].<ref name="pmid9374458">{{cite journal | vauthors = Muzio M, Ni J, Feng P, Dixit VM | title = IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling | journal = Science | volume = 278 | issue = 5343 | pages = 1612–5 | date = November 1997 | pmid = 9374458 | pmc =  | doi = 10.1126/science.278.5343.1612 }}</ref><ref name="pmid8599092">{{cite journal | vauthors = Cao Z, Henzel WJ, Gao X | title = IRAK: a kinase associated with the interleukin-1 receptor | journal = Science | volume = 271 | issue = 5252 | pages = 1128–31 | date = February 1996 | pmid = 8599092 | pmc = | doi = 10.1126/science.271.5252.1128 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Interleukin-1 receptor-associated kinase 1
| HGNCid = 6112
| Symbol = IRAK1
| AltSymbols =; IRAK; pelle
| OMIM = 300283
| ECnumber = 
| Homologene = 37496
| MGIid = 107420
| GeneAtlas_image1 = PBB_GE_IRAK1_201587_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004704 |text = NF-kappaB-inducing kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005149 |text = interleukin-1 receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0045323 |text = interleukin-1 receptor complex}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007178 |text = transmembrane receptor protein serine/threonine kinase signaling pathway}} {{GNF_GO|id=GO:0007250 |text = activation of NF-kappaB-inducing kinase}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}} {{GNF_GO|id=GO:0051259 |text = protein oligomerization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3654
    | Hs_Ensembl = ENSG00000184216
    | Hs_RefseqProtein = NP_001020413
    | Hs_RefseqmRNA = NM_001025242
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 152929145
    | Hs_GenLoc_end = 152938625
    | Hs_Uniprot = P51617
    | Mm_EntrezGene = 16179
    | Mm_Ensembl = ENSMUSG00000031392
    | Mm_RefseqmRNA = NM_008363
    | Mm_RefseqProtein = NP_032389
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 70266646
    | Mm_GenLoc_end = 70276641
    | Mm_Uniprot = Q8K4N7
  }}
}}
'''Interleukin-1 receptor-associated kinase 1''', also known as '''IRAK1''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: IRAK1 interleukin-1 receptor-associated kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3654| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: IRAK1 interleukin-1 receptor-associated kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3654| accessdate = }}</ref>
}}


==References==
[[Image:Toll-like receptor pathways revised.jpg|thumbnail|center|500px|Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations]]
{{reflist|2}}
 
==Further reading==
== Interactions ==
{{refbegin | 2}}
 
{{PBB_Further_reading
IRAK1 has been shown to [[Protein-protein interaction|interact]] with:
| citations =  
{{div col|colwidth=20em}}
*{{cite journal | author=Auron PE |title=The interleukin 1 receptor: ligand interactions and signal transduction. |journal=Cytokine Growth Factor Rev. |volume=9 |issue= 3-4 |pages= 221-37 |year= 1999 |pmid= 9918122 |doi= }}
* [[CHUK]],<ref name = pmid18180283/><ref name = pmid11096118/>
*{{cite journal | author=Cao Z, Henzel WJ, Gao X |title=IRAK: a kinase associated with the interleukin-1 receptor. |journal=Science |volume=271 |issue= 5252 |pages= 1128-31 |year= 1996 |pmid= 8599092 |doi= }}
* [[IKBKG]],<ref name = pmid18180283>{{cite journal | vauthors = Windheim M, Stafford M, Peggie M, Cohen P | title = Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase | journal = Molecular and Cellular Biology | volume = 28 | issue = 5 | pages = 1783–91 | date = March 2008 | pmid = 18180283 | pmc = 2258775 | doi = 10.1128/MCB.02380-06 }}</ref><ref name = pmid18347055>{{cite journal | vauthors = Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD | title = Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation | journal = Molecular and Cellular Biology | volume = 28 | issue = 10 | pages = 3538–47 | date = May 2008 | pmid = 18347055 | pmc = 2423148 | doi = 10.1128/MCB.02098-07 }}</ref>
*{{cite journal | author=Cao Z, Xiong J, Takeuchi M, ''et al.'' |title=TRAF6 is a signal transducer for interleukin-1. |journal=Nature |volume=383 |issue= 6599 |pages= 443-6 |year= 1996 |pmid= 8837778 |doi= 10.1038/383443a0 }}
* [[IKK2]],<ref name = pmid18180283/><ref name = pmid11096118>{{cite journal | vauthors = Vig E, Green M, Liu Y, Yu KY, Kwon HJ, Tian J, Goebl MG, Harrington MA | title = SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity | journal = The Journal of Biological Chemistry | volume = 276 | issue = 11 | pages = 7859–66 | date = March 2001 | pmid = 11096118 | doi = 10.1074/jbc.M010399200 }}</ref>
*{{cite journal | author=Brenner V, Nyakatura G, Rosenthal A, Platzer M |title=Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. |journal=Genomics |volume=44 |issue= 1 |pages= 8-14 |year= 1997 |pmid= 9286695 |doi= 10.1006/geno.1997.4822 }}
* [[Myd88]],<ref name = pmid11976320>{{cite journal | vauthors = Chen BC, Wu WT, Ho FM, Lin WW | title = Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 27 | pages = 24169–79 | date = July 2002 | pmid = 11976320 | doi = 10.1074/jbc.M106014200 }}</ref><ref name = pmid10383454>{{cite journal | vauthors = Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z | title = IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family | journal = The Journal of Biological Chemistry | volume = 274 | issue = 27 | pages = 19403–10 | date = July 1999 | pmid = 10383454 | doi = 10.1074/jbc.274.27.19403 }}</ref><ref name = pmid11960013>{{cite journal | vauthors = Li S, Strelow A, Fontana EJ, Wesche H | title = IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 8 | pages = 5567–72 | date = April 2002 | pmid = 11960013 | pmc = 122810 | doi = 10.1073/pnas.082100399 }}</ref><ref name = pmid11544529>{{cite journal | vauthors = Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA | title = Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction | journal = Nature | volume = 413 | issue = 6851 | pages = 78–83 | date = September 2001 | pmid = 11544529 | doi = 10.1038/35092578 }}</ref>
*{{cite journal | author=Huang J, Gao X, Li S, Cao Z |title=Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 24 |pages= 12829-32 |year= 1998 |pmid= 9371760 |doi= }}
* [[TRAF6]],<ref name = pmid10383454/><ref name = pmid11960013/><ref name="Muzio1997">{{cite journal|last1=Muzio|first1=M.|title=IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling|journal=Science|volume=278|issue=5343|year=1997|pages=1612–1615|issn=0036-8075|doi=10.1126/science.278.5343.1612|pmid=9374458}}</ref><ref name = pmid11518704>{{cite journal | vauthors = Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X | title = IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 41661–7 | date = November 2001 | pmid = 11518704 | doi = 10.1074/jbc.M102262200 }}</ref><ref name = pmid8837778>{{cite journal | vauthors = Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV | title = TRAF6 is a signal transducer for interleukin-1 | journal = Nature | volume = 383 | issue = 6599 | pages = 443–6 | date = October 1996 | pmid = 8837778 | doi = 10.1038/383443a0 }}</ref><ref name = pmid12566447>{{cite journal | vauthors = Takatsuna H, Kato H, Gohda J, Akiyama T, Moriya A, Okamoto Y, Yamagata Y, Otsuka M, Umezawa K, Semba K, Inoue J | title = Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling | journal = The Journal of Biological Chemistry | volume = 278 | issue = 14 | pages = 12144–50 | date = April 2003 | pmid = 12566447 | doi = 10.1074/jbc.M300720200 }}</ref><ref name = pmid10920205>{{cite journal | vauthors = Ling L, Goeddel DV | title = T6BP, a TRAF6-interacting protein involved in IL-1 signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 17 | pages = 9567–72 | date = August 2000 | pmid = 10920205 | pmc = 16905 | doi = 10.1073/pnas.170279097 }}</ref><ref name = pmid11259596>{{cite journal | vauthors = Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K | title = Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway | journal = Molecular and Cellular Biology | volume = 21 | issue = 7 | pages = 2475–84 | date = April 2001 | pmid = 11259596 | pmc = 86880 | doi = 10.1128/MCB.21.7.2475-2484.2001 }}</ref><ref name = pmid18234474>{{cite journal | vauthors = Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, Chen D | title = Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling | journal = Cellular Signalling | volume = 20 | issue = 4 | pages = 666–74 | date = April 2008 | pmid = 18234474 | doi = 10.1016/j.cellsig.2007.12.002 }}</ref>
*{{cite journal | author=Muzio M, Ni J, Feng P, Dixit VM |title=IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. |journal=Science |volume=278 |issue= 5343 |pages= 1612-5 |year= 1997 |pmid= 9374458 |doi= }}
* [[Ubiquitin C|UBC]],<ref name = pmid18180283/><ref name = pmid18347055/><ref name = pmid18724939>{{cite journal | vauthors = Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM | title = Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies | journal = Cell | volume = 134 | issue = 4 | pages = 668–78 | date = August 2008 | pmid = 18724939 | doi = 10.1016/j.cell.2008.07.039 }}</ref><ref name = pmid18326498>{{cite journal | vauthors = Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z, Li X | title = Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation | journal = The Journal of Biological Chemistry | volume = 283 | issue = 21 | pages = 14654–64 | date = May 2008 | pmid = 18326498 | pmc = 2386918 | doi = 10.1074/jbc.M706931200 }}</ref>
*{{cite journal | author=Muzio M, Natoli G, Saccani S, ''et al.'' |title=The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). |journal=J. Exp. Med. |volume=187 |issue= 12 |pages= 2097-101 |year= 1998 |pmid= 9625770 |doi= }}
* [[TOLLIP]],<ref name="TschoppBurns2000">{{cite journal | vauthors = Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F | title = Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor | journal = Nature Cell Biology | volume = 2 | issue = 6 | pages = 346–51 | date = June 2000 | pmid = 10854325 | doi = 10.1038/35014038 }}</ref>
*{{cite journal | author=Maschera B, Ray K, Burns K, Volpe F |title=Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB. |journal=Biochem. J. |volume=339 ( Pt 2) |issue= |pages= 227-31 |year= 1999 |pmid= 10191251 |doi= }}
* [[TLR4]].<ref name="HeJing2014">{{cite journal | vauthors = He X, Jing Z, Cheng G | title = MicroRNAs: new regulators of Toll-like receptor signalling pathways | journal = BioMed Research International | volume = 2014 | pages = 945169 | year = 2014 | pmid = 24772440 | doi = 10.1155/2014/945169 | pmc=3977468}}</ref>
*{{cite journal | author=Wesche H, Gao X, Li X, ''et al.'' |title=IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19403-10 |year= 1999 |pmid= 10383454 |doi= }}
*{{cite journal | author=Yang RB, Mark MR, Gurney AL, Godowski PJ |title=Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. |journal=J. Immunol. |volume=163 |issue= 2 |pages= 639-43 |year= 1999 |pmid= 10395652 |doi= }}
{{Div col end}}
*{{cite journal | author=Thomas JA, Allen JL, Tsen M, ''et al.'' |title=Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. |journal=J. Immunol. |volume=163 |issue= 2 |pages= 978-84 |year= 1999 |pmid= 10395695 |doi= }}
 
*{{cite journal | author=Reichwald K, Thiesen J, Wiehe T, ''et al.'' |title=Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions. |journal=Mamm. Genome |volume=11 |issue= 3 |pages= 182-90 |year= 2000 |pmid= 10723722 |doi= }}
== References ==
*{{cite journal | author=Burns K, Clatworthy J, Martin L, ''et al.'' |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. |journal=Nat. Cell Biol. |volume=2 |issue= 6 |pages= 346-51 |year= 2000 |pmid= 10854325 |doi= 10.1038/35014038 }}
{{reflist|33em}}
*{{cite journal | author=Böl G, Kreuzer OJ, Brigelius-Flohé R |title=Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus. |journal=FEBS Lett. |volume=477 |issue= 1-2 |pages= 73-8 |year= 2000 |pmid= 10899313 |doi= }}
 
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
== Further reading ==
*{{cite journal | author=Vig E, Green M, Liu Y, ''et al.'' |title=SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7859-66 |year= 2001 |pmid= 11096118 |doi= 10.1074/jbc.M010399200 }}
{{refbegin|33em}}
*{{cite journal | author=Li X, Commane M, Jiang Z, Stark GR |title=IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 8 |pages= 4461-5 |year= 2001 |pmid= 11287640 |doi= 10.1073/pnas.071054198 }}
* {{cite journal | vauthors = Auron PE | title = The interleukin 1 receptor: ligand interactions and signal transduction | journal = Cytokine & Growth Factor Reviews | volume = 9 | issue = 3-4 | pages = 221–37 | year = 1999 | pmid = 9918122 | doi = 10.1016/S1359-6101(98)00018-5 }}
*{{cite journal | author=Jensen LE, Whitehead AS |title=IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29037-44 |year= 2001 |pmid= 11397809 |doi= 10.1074/jbc.M103815200 }}
* {{cite journal | vauthors = Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV | title = TRAF6 is a signal transducer for interleukin-1 | journal = Nature | volume = 383 | issue = 6599 | pages = 443–6 | date = October 1996 | pmid = 8837778 | doi = 10.1038/383443a0 }}
*{{cite journal  | author=Qian Y, Commane M, Ninomiya-Tsuji J, ''et al.'' |title=IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41661-7 |year= 2001 |pmid= 11518704 |doi= 10.1074/jbc.M102262200 }}
* {{cite journal | vauthors = Brenner V, Nyakatura G, Rosenthal A, Platzer M | title = Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse | journal = Genomics | volume = 44 | issue = 1 | pages = 8–14 | date = August 1997 | pmid = 9286695 | doi = 10.1006/geno.1997.4822 }}
}}
* {{cite journal | vauthors = Huang J, Gao X, Li S, Cao Z | title = Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 24 | pages = 12829–32 | date = November 1997 | pmid = 9371760 | pmc = 24223 | doi = 10.1073/pnas.94.24.12829 }}
* {{cite journal | vauthors = Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A | title = The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6) | journal = The Journal of Experimental Medicine | volume = 187 | issue = 12 | pages = 2097–101 | date = June 1998 | pmid = 9625770 | pmc = 2212359 | doi = 10.1084/jem.187.12.2097 }}
* {{cite journal | vauthors = Maschera B, Ray K, Burns K, Volpe F | title = Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB | journal = The Biochemical Journal | volume = 339 | issue = 2 | pages = 227–31 | date = April 1999 | pmid = 10191251 | pmc = 1220149 | doi = 10.1042/0264-6021:3390227 }}
* {{cite journal | vauthors = Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z | title = IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family | journal = The Journal of Biological Chemistry | volume = 274 | issue = 27 | pages = 19403–10 | date = July 1999 | pmid = 10383454 | doi = 10.1074/jbc.274.27.19403 }}
* {{cite journal | vauthors = Yang RB, Mark MR, Gurney AL, Godowski PJ | title = Signaling events induced by lipopolysaccharide-activated toll-like receptor 2 | journal = Journal of Immunology | volume = 163 | issue = 2 | pages = 639–43 | date = July 1999 | pmid = 10395652 | doi =  }}
* {{cite journal | vauthors = Thomas JA, Allen JL, Tsen M, Dubnicoff T, Danao J, Liao XC, Cao Z, Wasserman SA | title = Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase | journal = Journal of Immunology | volume = 163 | issue = 2 | pages = 978–84 | date = July 1999 | pmid = 10395695 | doi =  }}
* {{cite journal | vauthors = Reichwald K, Thiesen J, Wiehe T, Weitzel J, Poustka WA, Rosenthal A, Platzer M, Strätling WH, Kioschis P | title = Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions | journal = Mammalian Genome | volume = 11 | issue = 3 | pages = 182–90 | date = March 2000 | pmid = 10723722 | doi = 10.1007/s003350010035 }}
* {{cite journal | vauthors = Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F | title = Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor | journal = Nature Cell Biology | volume = 2 | issue = 6 | pages = 346–51 | date = June 2000 | pmid = 10854325 | doi = 10.1038/35014038 }}
* {{cite journal | vauthors = Böl G, Kreuzer OJ, Brigelius-Flohé R | title = Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus | journal = FEBS Letters | volume = 477 | issue = 1-2 | pages = 73–8 | date = July 2000 | pmid = 10899313 | doi = 10.1016/S0014-5793(00)01759-2 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
* {{cite journal | vauthors = Vig E, Green M, Liu Y, Yu KY, Kwon HJ, Tian J, Goebl MG, Harrington MA | title = SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity | journal = The Journal of Biological Chemistry | volume = 276 | issue = 11 | pages = 7859–66 | date = March 2001 | pmid = 11096118 | doi = 10.1074/jbc.M010399200 }}
* {{cite journal | vauthors = Li X, Commane M, Jiang Z, Stark GR | title = IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 8 | pages = 4461–5 | date = April 2001 | pmid = 11287640 | pmc = 31857 | doi = 10.1073/pnas.071054198 }}
* {{cite journal | vauthors = Jensen LE, Whitehead AS | title = IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29037–44 | date = August 2001 | pmid = 11397809 | doi = 10.1074/jbc.M103815200 }}
* {{cite journal | vauthors = Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X | title = IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 41661–7 | date = November 2001 | pmid = 11518704 | doi = 10.1074/jbc.M102262200 }}
{{refend}}
{{refend}}


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[[Category:EC 2.7.11]]

Revision as of 00:03, 1 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Interleukin-1 receptor-associated kinase 1 is an enzyme that in humans is encoded by the IRAK1 gene.[1][2]

Function

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

Interactions

IRAK1 has been shown to interact with:

References

  1. ↑ Muzio M, Ni J, Feng P, Dixit VM (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. PMID 9374458.
  2. ↑ Cao Z, Henzel WJ, Gao X (February 1996). "IRAK: a kinase associated with the interleukin-1 receptor". Science. 271 (5252): 1128–31. doi:10.1126/science.271.5252.1128. PMID 8599092.
  3. ↑ "Entrez Gene: IRAK1 interleukin-1 receptor-associated kinase 1".
  4. ↑ 4.0 4.1 4.2 4.3 Windheim M, Stafford M, Peggie M, Cohen P (March 2008). "Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase". Molecular and Cellular Biology. 28 (5): 1783–91. doi:10.1128/MCB.02380-06. PMC 2258775. PMID 18180283.
  5. ↑ 5.0 5.1 Vig E, Green M, Liu Y, Yu KY, Kwon HJ, Tian J, Goebl MG, Harrington MA (March 2001). "SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity". The Journal of Biological Chemistry. 276 (11): 7859–66. doi:10.1074/jbc.M010399200. PMID 11096118.
  6. ↑ 6.0 6.1 Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD (May 2008). "Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation". Molecular and Cellular Biology. 28 (10): 3538–47. doi:10.1128/MCB.02098-07. PMC 2423148. PMID 18347055.
  7. ↑ Chen BC, Wu WT, Ho FM, Lin WW (July 2002). "Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88". The Journal of Biological Chemistry. 277 (27): 24169–79. doi:10.1074/jbc.M106014200. PMID 11976320.
  8. ↑ 8.0 8.1 Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
  9. ↑ 9.0 9.1 Li S, Strelow A, Fontana EJ, Wesche H (April 2002). "IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5567–72. doi:10.1073/pnas.082100399. PMC 122810. PMID 11960013.
  10. ↑ Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (September 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529.
  11. ↑ Muzio, M. (1997). "IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling". Science. 278 (5343): 1612–1615. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458.
  12. ↑ Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X (November 2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B". The Journal of Biological Chemistry. 276 (45): 41661–7. doi:10.1074/jbc.M102262200. PMID 11518704.
  13. ↑ Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV (October 1996). "TRAF6 is a signal transducer for interleukin-1". Nature. 383 (6599): 443–6. doi:10.1038/383443a0. PMID 8837778.
  14. ↑ Takatsuna H, Kato H, Gohda J, Akiyama T, Moriya A, Okamoto Y, Yamagata Y, Otsuka M, Umezawa K, Semba K, Inoue J (April 2003). "Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling". The Journal of Biological Chemistry. 278 (14): 12144–50. doi:10.1074/jbc.M300720200. PMID 12566447.
  15. ↑ Ling L, Goeddel DV (August 2000). "T6BP, a TRAF6-interacting protein involved in IL-1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9567–72. doi:10.1073/pnas.170279097. PMC 16905. PMID 10920205.
  16. ↑ Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K (April 2001). "Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway". Molecular and Cellular Biology. 21 (7): 2475–84. doi:10.1128/MCB.21.7.2475-2484.2001. PMC 86880. PMID 11259596.
  17. ↑ Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, Chen D (April 2008). "Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling". Cellular Signalling. 20 (4): 666–74. doi:10.1016/j.cellsig.2007.12.002. PMID 18234474.
  18. ↑ Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM (August 2008). "Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies". Cell. 134 (4): 668–78. doi:10.1016/j.cell.2008.07.039. PMID 18724939.
  19. ↑ Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z, Li X (May 2008). "Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation". The Journal of Biological Chemistry. 283 (21): 14654–64. doi:10.1074/jbc.M706931200. PMC 2386918. PMID 18326498.
  20. ↑ Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nature Cell Biology. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.
  21. ↑ He X, Jing Z, Cheng G (2014). "MicroRNAs: new regulators of Toll-like receptor signalling pathways". BioMed Research International. 2014: 945169. doi:10.1155/2014/945169. PMC 3977468. PMID 24772440.

Further reading

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