CCRL1: Difference between revisions

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'''C-C chemokine receptor type 11''' is a [[protein]] that in humans is encoded by the ''CCRL1'' [[gene]].<ref name="pmid10767544">{{cite journal | vauthors = Khoja H, Wang G, Ng CT, Tucker J, Brown T, Shyamala V | title = Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart | journal = Gene | volume = 246 | issue = 1–2 | pages = 229–38 |date=May 2000 | pmid = 10767544 | pmc = | doi =10.1016/S0378-1119(00)00076-7  }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Chemokine (C-C motif) receptor-like 1
| HGNCid = 1611
| Symbol = CCRL1
| AltSymbols =; CCBP2; CCR10; CC-CKR-11; CCR11; CCX-CKR; CKR-11; PPR1; VSHK1
| OMIM = 606065
| ECnumber = 
| Homologene = 49474
| MGIid = 2181676
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51554
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_057641
    | Hs_RefseqmRNA = NM_016557
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 252837
    | Mm_Ensembl = ENSMUSG00000041748
    | Mm_RefseqmRNA = NM_145700
    | Mm_RefseqProtein = NP_663746
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 103942502
    | Mm_GenLoc_end = 103985278
    | Mm_Uniprot = Q924I3
  }}
}}
'''Chemokine (C-C motif) receptor-like 1''', also known as '''CCRL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51554| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.<ref name="entrez">{{cite web | title = Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51554| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.<ref name="entrez">{{cite web | title = Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51554| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ACKR4}}
* {{UCSC gene info|CCR10}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Bacon KB, Schall TJ, Dairaghi DJ |title=RANTES activation of phospholipase D in Jurkat T cells: requirement of GTP-binding proteins ARF and RhoA. |journal=J. Immunol. |volume=160 |issue= 4 |pages= 1894-900 |year= 1998 |pmid= 9469451 |doi=  }}
*{{cite journal  | vauthors=Bacon KB, Schall TJ, Dairaghi DJ |title=RANTES activation of phospholipase D in Jurkat T cells: requirement of GTP-binding proteins ARF and RhoA |journal=J. Immunol. |volume=160 |issue= 4 |pages= 1894–900 |year= 1998 |pmid= 9469451 |doi=  }}
*{{cite journal  | author=Gosling J, Dairaghi DJ, Wang Y, ''et al.'' |title=Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2851-6 |year= 2000 |pmid= 10706668 |doi=  }}
*{{cite journal  | vauthors=Gosling J, Dairaghi DJ, Wang Y |title=Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2851–6 |year= 2000 |pmid= 10706668 |doi=  10.4049/jimmunol.164.6.2851|display-authors=etal}}
*{{cite journal  | author=Schweickart VL, Epp A, Raport CJ, Gray PW |title=CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9550-6 |year= 2000 |pmid= 10734104 |doi= }}
*{{cite journal  | vauthors=Schweickart VL, Epp A, Raport CJ, Gray PW |title=CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9550–6 |year= 2000 |pmid= 10734104 |doi=10.1074/jbc.275.13.9550 }}
*{{cite journal  | author=Khoja H, Wang G, Ng CT, ''et al.'' |title=Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart. |journal=Gene |volume=246 |issue= 1-2 |pages= 229-38 |year= 2000 |pmid= 10767544 |doi= }}
*{{cite journal  | vauthors=Schweickart VL, Epp A, Raport CJ, Gray PW |title=CCR11 is a functional receptor for the monocyte chemoaattractant protein family of chemokines |journal= The Journal of Biological Chemistry|volume=276 |issue= 1 |pages= 856 |year=  2001|pmid= 11134065 |doi=  }}
*{{cite journal  | author=Schweickart VL, Epp A, Raport CJ, Gray PW |title=CCR11 is a functional receptor for the monocyte chemoaattractant protein family of chemokines. |journal= |volume=276 |issue= 1 |pages= 856 |year=  |pmid= 11134065 |doi=  }}
*{{cite journal  | vauthors=Townson JR, Nibbs RJ |title=Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR |journal=Eur. J. Immunol. |volume=32 |issue= 5 |pages= 1230–41 |year= 2002 |pmid= 11981810 |doi= 10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L}}
*{{cite journal  | author=Townson JR, Nibbs RJ |title=Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. |journal=Eur. J. Immunol. |volume=32 |issue= 5 |pages= 1230-41 |year= 2002 |pmid= 11981810 |doi= 10.1002/1521-4141(200205)32:5&lt;1230::AID-IMMU1230&gt;3.0.CO;2-L }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Comerford I, Milasta S, Morrow V |title=The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro |journal=Eur. J. Immunol. |volume=36 |issue= 7 |pages= 1904–16 |year= 2006 |pmid= 16791897 |doi= 10.1002/eji.200535716 |display-authors=etal}}
*{{cite journal  | author=Comerford I, Milasta S, Morrow V, ''et al.'' |title=The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro. |journal=Eur. J. Immunol. |volume=36 |issue= 7 |pages= 1904-16 |year= 2006 |pmid= 16791897 |doi= 10.1002/eji.200535716 }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
{{Chemokine receptors}}
{{Chemokine receptors}}
{{Chemokine receptor modulators}}
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[[Category:Chemokine receptors]]
[[Category:Chemokine receptors]]
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{{transmembranereceptor-stub}}

Revision as of 09:19, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.[1][2]

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.[2]

References

  1. Khoja H, Wang G, Ng CT, Tucker J, Brown T, Shyamala V (May 2000). "Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart". Gene. 246 (1–2): 229–38. doi:10.1016/S0378-1119(00)00076-7. PMID 10767544.
  2. 2.0 2.1 "Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1".

External links

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.