chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a proteinligand that in humans is encoded by the CXCL13gene.[1][2]
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as Angioimmunoblastic T-cell Lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.[5]
↑ Jump up to: 2.02.1Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. doi:10.1038/35876. PMID9486651.
↑Ansel KM, Harris RB, Cyster JG (January 2002). "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity. 16 (1): 67–76. doi:10.1016/S1074-7613(01)00257-6. PMID11825566.
↑Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (July 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature. 406 (6793): 309–14. doi:10.1038/35018581. PMID10917533.
↑de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (June 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–63. doi:10.1182/blood-2006-10-055145. PMID17284527.
