IRAK2

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VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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n/a

RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.[1][2]

Function

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.[2]

Interactions

IRAK2 has been shown to interact with TRAF6[1][3] and Myd88.[1][3][4]

References

  1. 1.0 1.1 1.2 Muzio M, Ni J, Feng P, Dixit VM (Nov 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. PMID 9374458.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  2. 2.0 2.1 "Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2".<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. 3.0 3.1 Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  4. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

Further reading

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  • Auron PE (1999). "The interleukin 1 receptor: ligand interactions and signal transduction". Cytokine & Growth Factor Reviews. 9 (3–4): 221–37. doi:10.1016/S1359-6101(98)00018-5. PMID 9918122.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Maschera B, Ray K, Burns K, Volpe F (Apr 1999). "Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB". The Biochemical Journal. 339 ( Pt 2) (2): 227–31. doi:10.1042/0264-6021:3390227. PMC 1220149. PMID 10191251.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA (Sep 2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • McDermott EP, O'Neill LA (Mar 2002). "Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1". The Journal of Biological Chemistry. 277 (10): 7808–15. doi:10.1074/jbc.M108133200. PMID 11744690.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (Feb 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Bin LH, Xu LG, Shu HB (Jul 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Kuzmin I, Geil L, Gibson L, Cavinato T, Loukinov D, Lobanenkov V, Lerman MI (Feb 2005). "Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter". Journal of Molecular Biology. 346 (2): 411–22. doi:10.1016/j.jmb.2004.11.066. PMID 15670593.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  • Keating SE, Maloney GM, Moran EM, Bowie AG (Nov 2007). "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination". The Journal of Biological Chemistry. 282 (46): 33435–43. doi:10.1074/jbc.M705266200. PMID 17878161.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>