CIT (gene)

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Citron (rho-interacting, serine/threonine kinase 21)
Symbols CIT ; CRIK; KIAA0949; STK21
External IDs Template:OMIM5 Template:MGI HomoloGene21404
RNA expression pattern
PBB GE CIT 212801 at tn.png
PBB GE CIT gnf1h02793 at tn.png
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Citron (rho-interacting, serine/threonine kinase 21), also known as CIT, is a human gene.[1]


  1. "Entrez Gene: CIT citron (rho-interacting, serine/threonine kinase 21)".

Further reading

  • Madaule P, Furuyashiki T, Reid T; et al. (1996). "A novel partner for the GTP-bound forms of rho and rac". FEBS Lett. 377 (2): 243–8. PMID 8543060.
  • Di Cunto F, Calautti E, Hsiao J; et al. (1998). "Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron". J. Biol. Chem. 273 (45): 29706–11. PMID 9792683.
  • Zhang W, Vazquez L, Apperson M, Kennedy MB (1999). "Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus". J. Neurosci. 19 (1): 96–108. PMID 9870942.
  • Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. PMID 10231032.
  • Husi H, Ward MA, Choudhary JS; et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.
  • Di Cunto F, Imarisio S, Hirsch E; et al. (2000). "Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis". Neuron. 28 (1): 115–27. PMID 11086988.
  • Liu H, Di Cunto F, Imarisio S, Reid LM (2003). "Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes". J. Biol. Chem. 278 (4): 2541–8. doi:10.1074/jbc.M210391200. PMID 12411428.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Ozeki Y, Tomoda T, Kleiderlein J; et al. (2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 289–94. doi:10.1073/pnas.0136913100. PMID 12506198.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Irobi J, Van Impe K, Seeman P; et al. (2004). "Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy". Nat. Genet. 36 (6): 597–601. doi:10.1038/ng1328. PMID 15122253.
  • Lyons-Warren A, Chang JJ, Balkissoon R; et al. (2005). "Evidence of association between bipolar disorder and Citron on chromosome 12q24". Mol. Psychiatry. 10 (9): 807–9. doi:10.1038/ PMID 15983625.
  • Gruneberg U, Neef R, Li X; et al. (2006). "KIF14 and citron kinase act together to promote efficient cytokinesis". J. Cell Biol. 172 (3): 363–72. doi:10.1083/jcb.200511061. PMID 16431929.
  • Scherer SE, Muzny DM, Buhay CJ; et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.
  • Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
  • Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Paramasivam M, Chang YJ, LoTurco JJ (2007). "ASPM and citron kinase co-localize to the midbody ring during cytokinesis". Cell Cycle. 6 (13): 1605–12. PMID 17534152.

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